0000000000077583
AUTHOR
Rainer Haag
Enhanced Permeability and Retention-like Extravasation of Nanoparticles from the Vasculature into Tuberculosis Granulomas in Zebrafish and Mouse Models
The enhanced permeability and retention (EPR) effect is the only described mechanism enabling nanoparticles (NPs) flowing in blood to reach tumors by a passive targeting mechanism. Here, using the transparent zebrafish model infected with Mycobacterium marinum we show that an EPR-like process also occurs allowing different types of NPs to extravasate from the vasculature to reach granulomas that assemble during tuberculosis (TB) infection. PEGylated liposomes and other NP types cross endothelial barriers near infection sites within minutes after injection and accumulate close to granulomas. Although similar to 100 and 190 nm NPs concentrated most in granulomas, even similar to 700 nm liposo…
Bürgenstock: Stereochemie ohne Grenzen
Auch in diesem Fruhjahr war der Burgenstock oberhalb von Luzern Schauplatz der ESF/-EUCHEM Conference on Stereochemistry. State-of-the-Art-Synthesemethoden und Entwicklungen an den Schnittstellen der Chemie zu den Bio- und Materialwissenschaften bildeten die thematischen Schwerpunkte der Tagung.
Supramolecular polymerization of sulfated dendritic peptide amphiphiles into multivalent L-selectin binders
The synthesis of a sulfate-modified dendritic peptide amphiphile and its self-assembly into one-dimensional rod-like architectures in aqueous medium is reported. The influence of the ionic strength on the supramolecular polymerization was probed via circular dichroism spectroscopy and cryogenic transmission electron microscopy. Physiological salt concentrations efficiently screen the charges of the dendritic building block equipped with eight sulfate groups and trigger the formation of rigid supramolecular polymers. Since multivalent sulfated supramolecular structures mimic naturally occurring L-selectin ligands, the corresponding affinity was evaluated using a competitive SPR binding assay…