Effetti dell’influenza dell’ ossido nitrico su modelli di ipereccitabilità sperimentalmente indotta: studio elettrofisiologico comparativo in vivo e in vitro nel ratto.

Cardiovascular effects induced by rolipram, a selective cAMP phosphodiesterase inhibitor: Interaction with adrenergic and calcium affecting drugs

Antidepressant and anxiolytic effects of alprazolam versus the conventional. antidepressant desipramine and the anxiolytic diazepam in the forced swim test in rats

The antidepressant and anxiolytic effects of alprazolam were compared to those of desipramine, diazepam and buspirone in the forced swim test. Subchronic alprazolam induced a reduction in immobility similar to that of desipramine in 'non-pretested' and 'pretested' rats. In 'non-pretested' rats, the anti-immobility effect of desipramine was potentiated by diazepam and alprazolam, given before subchronic desipramine, while the anti-immobility effect of subchronic alprazolam was counteracted by diazepam. Diazepam, administered before the pretest session, counteracted, 24 h later, the anti-immobility effect of subchronic desipramine and alprazolam; alprazolam counteracted the anti-immobility ef…

Effects of pre- and postnatal exposure to 5-methoxytryptamine and early handling on an object-place association learning task in adolescent rat offspring.

A reduction in 5-HT1A receptor response enhances learning and memory performance in rats. Pre- and postnatal treatment with 5-methoxytryptamine (5MT), a non-selective serotonergic agonist, and early handling, reduce the number of 5-HT1A receptors in neonatal and pre-pubertal rat progeny. The aim of this study was to investigate in adolescent male rats the consequences of pre- and postnatal treatment with 5MT and its interaction with early handling on an object-place association learning task, the "Can test", a motivated, non-aversive, spatial/object discrimination task. Results show that a single daily injection of 5MT from gestational days 12 to 21 (1 mg/kg s.c.) and from postnatal days 2 …

Influence of the suspension of continued treatment with flurazepam and amobarbital on two discrimination learning schedules.

The authors have studied the effect of the suspension of chronic treatment with flurazepam and amobarbital on the operant behavior of rats that for the first time were in the presence of two fixed-interval discrimination schedules. With the sound discrimination schedule, the responses emitted by the treated animals had characteristics similar to those of control animals. With the temporal discrimination schedule, though it is not possible to distinguish between learning rates, modifications in the intensity of the effect (increases in lever pressing) indicate that, considering the doses, the action of flurazepam is slight and that of amobarbital clear and statistically significant.

VizieR Online Data Catalog: 46 open clusters GaiaDR2 HR diagrams (Gaia Collaboration, 2018)

We have determined the membership of 46 open clusters. For the nine clusters within 250pc we determined optimised parallaxes based on the combined information extracted from the measured parallax and proper motion values. These clusters are : in Tables A1a & A3: alphaPer, Blanco1, ComaBer, Hyades, IC2391, IC2602, NGC2451A, Pleiades, Praesepe. The remaining 37 clusters are in Table A1b & A4: Coll140, IC4651, IC4665, IC4725, IC4756, NGC0188, NGC0752, NGC0869, NGC0884, NGC1039, NGC1901, NGC2158, NGC2168, NGC2232, NGC2323, NGC2360, NGC2422, NGC2423, NGC2437, NGC2447, NGC2516, NGC2547, NGC2548, NGC2682, NGC3228, NGC3532, NGC6025, NGC6281, NGC6405, NGC6475, NGC6633, NGC6774, NGC6793, NGC7092, Sto…

Evaluation of alprazolam-induced behavioural effects: differences with chlordiazepoxide after interaction with desipramine and rolipram, a cAMP phosphodiesterase inhibitor.

VizieR Online Data Catalog: Gaia DR2 sources in GC and dSph (Gaia Collaboration+, 2018)

The files contains lists of possible members of each of the objects (75 globular clusters, 9 dwarf spheroidal galaxies, the Bootes I UFD, the LMC and SMC). The stars in these lists have been selected and used to determine the astrometric parameters of the corresponding objects following either the procedures described in Sec. 2.1 (for the clusters and dwarfs) or in Sec. 2.2 (for the LMC and SMC). The first column is the "source_id" as given by Gaia, the ra and declination of the star in degrees, and its G-band magnitude (known as "photgmean_mag" in the Gaia archive). (2 data files).

Pregnenolone sulphate faciltates object recognition and reduces depressive-like behaviour in male adult rats

Single, intense prenatal stress decreases emotionality and enhances learning performance in the adolescent rat offspring: Interaction with a brief, daily maternal separation.

Perinatal manipulations can lead to neurobehavioural changes in the progeny. In this study we investigated, in adolescent male rat offspring, the consequences of a single, intense prenatal stress induced by a 120 min-maternal immobilization at gestational day 16, and of a daily, brief maternal separation from postnatal day 2 until 21, on: unconditioned fear/anxiety-like behaviour in open field and in elevated plus-maze; learning performance in the "Can test", a non-aversive spatial and tactile/visual task; corticosterone plasma levels under basal and stress-induced conditions. Our results indicate that both prenatal stress and maternal separation procedures decrease emotionality and enhance…

Single and repeated treatment with chlordiazepoxide and sodium valproate and head-twitch responses induced in rats with rolipram, a potential antidepressant drug

Effects of desipramine and alprazolam in the forced swim test in rats after long-lasting termination of chronic exposure to picrotoxin and pentylenetetrazol.

Abstract Rats were treated for 5 weeks with three subconvulsant doses of picrotoxin (PTX) and pentylenetetrazol (PTZ) per week to induce a persistent reduction of the GABA A receptor function which results in chemical kindling. Fifteen days after termination of this treatment schedule, the effect of desipramine (DMI) and alpraxolam (ALP) on immobility time in the forced swim test (FST) was evaluated. Chronic PTX and PTZ did not alter the immobility time. Acute PTX and PTZ reduced the immobility of rats chronically treated with vehicle but not of those exposed chronically to PTX and PTZ. Chronic PTX did not influence the anti-immobility effect of DMI, but blocked that of ALP. Chronic PTZ mar…

Reversal of prenatal diazepam-induced deficit in a spatial-object learning task by brief, periodic maternal separation in adult rats.

In the rat, prenatal exposure to diazepam (DZ) induces a permanent reduction in GABA/BZ receptor (R) function and behavioural abnormalities. Environmental modifications during early stages of life can influence brain development and induce neurobiological and behavioural changes throughout adulthood. Indeed, a subtle, periodic, postnatal manipulation increases GABA/BZ R activity and produces facilitatory effects on neuroendocrine and behavioural responses. We here investigated the impact of prenatal treatment with DZ on learning performance in adult 3- and 8-month-old male rats and the influence of a brief, periodic maternal separation on the effects exerted by prenatal DZ exposure. Learnin…

The validity of animal models of depression in the identification of antidepressant drugs

Modification of depressant and disinhibitory action of flurazepam during short term treatment in the rat

Employing a fixed-interval schedule of reinforcement (temporal discrimination), alternated punished (fixed-ratio) and unpunished (variable-ratio) schedules of reinforcement, a Conditioned Avoidance Response, and studying its interaction with Pentobarbital on general anaesthesia, it has been shown that flurazepam hydrochloride after a single treatment induces very intense depressant effects and slight disinhibitory effects. Short term treatment at longer than daily intervals reduces the depressant effect and unmasks the disinhibitory effect. The phenomenon is probably caused by selective tolerance concerning the depressant action. The results are discussed from the point of view of the signi…

Water-intake and conflict-behaviour after acute and chronic treatment with rolipram, a phosphodiesterase inhibitor; interaction with chlordiazepoxide

NMDA-GABA interactions in an animal model of behaviour: a gating mechanism from motivation toward psychotic-like symptoms

We studied the effects of desipramine, alprazolam, muscimol and dizocilpine (MK-801) (alone or associated with desipramine) in the forced swimming test in rats after long-lasting termination of chronic exposure to vehicle and pentylenetetrazol. Sensitisation with pentylenetetrazol was ineffective in changing immobility time in the forced swimming test compared to vehicle treatment; pentylenetetrazol enhanced the anti-immobility effect of desipramine, abolished the anti-immobility effect of alprazolam and did not affect the anti-immobility effect of muscimol. MK-801 at the dose that did not modify immobility time in vehicle-treated rats and in pentylenetetrazol-treated animals strongly poten…

The effects of castration and of progestin-oestrogen combinations upon avoidance condtioning in female rats

Summary Using avoidance conditioning the authors show that female rats, three months after castration, emit a lower number of responses. Isolation has no effect whatever on rats, whether normal or castrated. Brief treatment with progestin-oestrogen combinations, interrupted 60 hours before the commencement of the session, brings the behaviour of castrated rats back to the norm. Identical effects occur with the use of a cortical stimulating drug (methylphenidate); while, the action of this drug soon ceases, the effect of hormonal treatment lasts for the duration of the experiments. The results are discussed with reference to the significance to be attributed to the experiments.

Head-twitch and forepaw-shake responses after single and repeated treatment with rolipram: interaction with noradrenergic and dopaminergic agonists and antagonists.

Conflict-behaviour and temporal discrimination performance in the rat: Comparison between alprazolam and various conventional benzodiazepines

Perinatal exposure to 5-methoxytryptamine, behavioural-stress reactivity and functional response of 5-HT1A receptors in the adolescent rat.

Abstract Serotonin is involved in a wide range of physiological and patho-physiological mechanisms. In particular, 5-HT1A receptors are proposed to mediate stress-adaptation. The aim of this research was to investigate in adolescent rats: first, the consequences of perinatal exposure to 5-metoxytryptamine (5MT), a 5-HT1/5-HT2 serotonergic agonist, on behavioural-stress reactivity in elevated plus maze, open field and forced swim tests; secondly, whether the behavioural effects induced by perinatal exposure to 5MT on open field and forced swim tests were affected by the selective 5-HT1A receptor agonist LY 228729, a compound able to elicit a characteristic set of motor behaviours on these ex…

Psychosis onset: Use of Cannabis X COMT Interaction. Case-only Design analysis in a First-Episode Psychosis Sample.

Un ulteriore risultato

Basato sul racconto di casi clinici concreti seguiti sia nel privato che nel pubblico e narrati con piacevole fluidità, il lavoro entra nel mondo dello psichismo mafioso e spiega il fenomeno “mafia” da un punto di vista antropo-psichico. Un contributo di grande attualità in un momento in cui il dramma “mafie” è dilagato anche al nord squassando il nostro paese.