Is resective surgery still the best practice for ONJ stage III? A case report of a conservative therapy

Root resorption caused by osteoma growth

introduction. Osteoma is a benign and asymptomatic neoplasm, consisting of well-differentiated mature bone. The solitary osteoma may be classified as: peripheral when arising from the periosteum, central when arising from the endosteum and extraskeletal when arising in soft tissue. The etiology of osteoma is still unclear. Some reported cas- es did have a clear history of trauma; however, this was not the case in the majority of cases. Whereas peripheral osteomas are fairly easy to diagnose, central osteomas pose a more challenging diagnostic problem and need to be differentiated from other similar lesions of the jaws, such as central ossifying fibroma, osteoblastoma, cementoblas- toma and …

Osteonecrosis of the jaw after long-term oral bisphosphonates, followed by short-term denosumab treatment for osteoporosis: a case report

Bisphosphonates and denosumab are antiresoptive agents and are mainly used for management of metastatic bone cancer, osteoporosis and other diseases. Bisphosphonates (BP) can reduce skeletal related events (SRE) by 30–50%1; denosumab (D) has been found even more effective than BP2. BP and D have been both associated to osteonecrosis of the jaw (ONJ). We report a case of an osteoporotic woman (62 yrs), complaining maxillary intense pain after a recent tooth molar extraction, observed in July 2013 at our centre. She mentioned previous treatments with monthly ibandronate (Bonviva ® 150 mg) per os (from January 2003 to April 2010), risedronate (35 mg weekly, from May 2010 to May 2012) and two a…

Differential diagnosis of diffused oral mucosal pigmented lesion: a case of Dubreuilh’s melanosis

Healing evaluation by means of Optical Coherence Tomography of an extraction socket with L-PRF application in a patient at ONJ risk: a case report

Spontaneous healing of osteonecrosis of the jaw after interruption of target therapy in a patient with lung cancer

L-PRF application in extraction sockets of bisphosphonate-treated patients: preliminary results

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe adverse event related to bisphosphonates (BPs) therapy; tooth extraction has been described as the main trigger. Autologous platelet concentrates, such Leukocyte-Platelet Rich Fibrin (L-PRF, Intraspin !) are designed to release platelet growth factors, improving the tissue healing in oral surgery. The aim of this study was to evaluate the efficacy and safety of our dental extraction protocol applied in BPs patients.