Is resective surgery still the best practice for ONJ stage III? A case report of a conservative therapy

DOCTORAL: THE FREE APP FOR TUTORING IN SUPPORTIVE ORAL CARE

To introduce the version 2.0 of DoctOral free app, created for tutoring medical/dental professionals (and students) in the clinical recognition of oral lesions and dental treatment planning in patients at risk of ONJ drug- related.

GOTeC: INTERDISCIPLINARY TUMOR BOARD FOR THE DIAGNOSIS AND TREATMENTS OF HEAD AND NECK CANCERS

Expression of apoptosis and proliferation regulating markers in OSCC

L’odontoiatria a misura del paziente con patologia osteometabolica a rischio di osteonecrosi delle ossa mascellari da farmaci.

L’osteonecrosi delle ossa mascellari (ONJ) da farmaci è una severa patologia odontoiatrica, recentemente defi nita come «una reazione avversa farmacocorrelata, caratterizzata dalla progressiva distruzione e necrosi dell’osso mandibolare e/o mascellare di soggetti esposti al trattamento con farmaci per cui sia accertato un aumentato rischio di malattia, in assenza di un pregresso trattamento radiante»1-3. I pazienti osteometabolici a rischio di sviluppare l’ONJ sono quelli sottoposti a terapia con bisfosfonati (in particolare aminobisfosfonati o Nitrogen-containing BisPhosphonate/NBP) e, più recentemente, con denosumab (anticorpo monoclonale anti-RANKL)4. Tali farmaci antiriassorbitivi carat…

Oral Lichen Planus: a new experimental therapeutic protocol by means of oxygen-ozone mixture injection.

Differential diagnosis of diffused oral mucosal pigmented lesion: a case of Dubreuilh’s melanosis

A misleading infection in a psoriatic patient: a challenging diagnosis of orocutaneous leishmaniasis

Optical Coherence Tomography (OCT) and Oral Potentially Malignant Disorders: critical review on potential diagnostic patterns

Time to onset of bisphosphonate-related osteonecrosis of the jaws: a multicentre retrospective cohort study

Objectives: Osteonecrosis of the jaw (ONJ) is a potentially severe adverse effect of bisphosphonates (BP). Although the risk of ONJ increases with increasing duration of BP treatment, there are currently no reliable estimates of the ONJ time to onset (TTO). The objective of this study was to estimate the TTO and associated risk factors in BP-treated patients. Subjects and Methods: Retrospective analysis of data from 22 secondary care centres in seven countries relevant to 349 patients who developed BP-related ONJ between 2004 and 2012. Results: The median (95%CI) TTO was 6.0 years in patients treated with alendronate (n = 88) and 2.2 years in those treated with zoledronate (n = 218). Multiv…

knowledge, practice and attitude about OSCC prevention among Calabrian primary care physicians: an observational study

Principal adverse events due to everolimus therapy. A systematic review of the literature

Ozone insufflation and l-prf application in an idiopathic and recurrent case of osteonecrosis of the maxilla

Surgical treatment of medication-related osteonecrosis of the jaws with addiction of L-PRF: preliminary results

Early detection of amyloid light-chain amyloidosis: a case report of oral primary manifestation

Oral health assessment in palliate patients: an exploratory preliminary survey

Follow-up of non-exposed ONJ related to bisphosphonate: a two-year study

Aim. Osteonecrosis of the jaw (ONJ) is a serious sideeffect of amine bisphosphonate (NBP) and/or other antiresorptive agents frequently used in the management of osteometabolic and cancer-related condition. The traditional ONJ definition exclude patients who present the non-exposed variant. However, according to recent data, staging and monitoring of ONJ should be closely linked to clinical and radiological manifestation regardless of the presence of bone exposed. The aim of this study was a descriptive analysis of a case series of patients with non-exposed ONJ (exclusively related to NBP) monitoring for two years. Methods. From 2012 to 2014, 16 patient [7 oncological (F/M=3/4; mean age=66,…

Malignant transformation of oral leukoplakia in oral squamous cell carcinoma: a case report.

Development of OloHealth, a teledentistry platform for the ONJ prevention in Sicily: preliminary reports

Epithelial-myoepithelial carcinoma of the minor salivary glands: a case report

Concept therapy: Interdisciplinary tumor board for the diagnosis and treatments of head and neck cancer

ONJ in osteometabolic patients: NO guilty verdict for teeth extraction

The aim of this study is to evaluate retrospectively the impact of some variables on the risk of oNJ onset in osteometabolic non-cancer patients by logistic regression analyses.

Osteonecrosis of the jaw prevention in oncological patients: preliminary results from a teledentistry sicilian project

PREVENTION OF THE DRUG-RELATED OSTEONECROSIS OF THE JAW (ONJ): PRELIMINARY DATA OF THE PROMaF PROTOCOL

Stomatitis and vR-TkI: a review of current literature in 4369 patients

the following review was performed to answer to the question “What is the rate of incidence of oral stomatitis in patients treated with VegF tKis?”