0000000000082253

AUTHOR

Nicolas Guilbaud

showing 2 related works from this author

Triterpene saponins from Schefflera abyssinica

2006

chemistry.chemical_classificationchemistry.chemical_compoundHederageninbiologyTriterpenechemistryTraditional medicineAraliaceaebiology.organism_classificationBiochemistryOleanolic acidEcology Evolution Behavior and SystematicsScheffleraBiochemical Systematics and Ecology
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Pursaethosides A-E, triterpene saponins from Entada pursaetha.

2005

Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the n-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.

MimosaSaponinPharmaceutical SciencePharmacognosyEntada pursaethaAnalytical ChemistryTriterpenoidTriterpeneDrug DiscoveryTumor Cells CulturedHumansCameroonNuclear Magnetic Resonance BiomolecularPharmacologychemistry.chemical_classificationPlants MedicinalMolecular StructureOrganic ChemistryGlycosideSaponinsAntineoplastic Agents PhytogenicTerpenoidTriterpenesHuman colon cancerComplementary and alternative medicinechemistryBiochemistryMolecular MedicineDrug Screening Assays AntitumorJournal of natural products
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