0000000000083195

AUTHOR

Mahmut Ilker Yilmaz

showing 4 related works from this author

The role of plasma triglyceride/high-density lipoprotein cholesterol ratio to predict cardiovascular outcomes in chronic kidney disease.

2015

Background Cardiovascular disease (CVD) risk is substantially increased in subjects with chronic kidney disease (CKD). The Triglycerides (TG) to High-Density Lipoprotein Cholesterol (HDL-C) ratio is an indirect measure of insulin resistance and an independent predictor of cardiovascular risk. No study to date has been performed to evaluate whether the TG/HDL-C ratio predicts CVD risk in patients with CKD. Methods A total of 197 patients (age 53 ± 12 years) with CKD Stages 1 to 5, were enrolled in this longitudinal, observational, retrospective study. TG/HDL-C ratio, HOMA-IR indexes, serum asymmetric dimethyl arginine (ADMA), high sensitivity C-reactive protein (CRP), parathyroid hormone (PT…

AdultMalemedicine.medical_specialtyFlow mediated dilatationTriglyceride to HDL-cholesterol ratioEndocrinology Diabetes and MetabolismAsymmetric dimethyl arginineClinical BiochemistryRenal functionClinical nutritionArginineGastroenterologychemistry.chemical_compoundEndocrinologyInsulin resistanceHigh-density lipoproteinInternal medicineChronic kidney diseasemedicineHumansLongitudinal StudiesRenal Insufficiency ChronicSerum AlbuminTriglyceridesAgedRetrospective StudiesBiochemistry medicalbiologybusiness.industryCholesterolResearchBiochemistry (medical)C-reactive proteinCholesterol HDLMiddle Agedmedicine.diseaseEndocrinologyC-Reactive ProteinchemistryCardiovascular DiseasesParathyroid Hormonebiology.proteinlipids (amino acids peptides and proteins)FemalebusinessBiomarkersKidney diseaseLipidologyGlomerular Filtration RateLipids in health and disease
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Search for the decay Bs0→μ+μ− with the ATLAS detector

2012

A blind analysis searching for the decay B-s(0) -> mu(+)mu(-) has been performed using proton-proton collisions at a centre-of-mass energy of 7 TeV recorded with the ATLAS detector at the LHC. W ...

PhysicsNuclear and High Energy PhysicsParticle physicsLarge Hadron ColliderPhysics::Instrumentation and Detectors010308 nuclear & particles physicsAtlas detectorHigh Energy Physics::Phenomenology7. Clean energy01 natural sciencesNuclear physicsmedicine.anatomical_structureAtlas (anatomy)0103 physical sciencesmedicinePhysics::Accelerator PhysicsHigh Energy Physics::ExperimentB mesonNuclear Experiment010306 general physicsPhysics Letters B
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Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma

2016

Obesity increases hepatocellular carcinoma (HCC) risks via unknown mediators. We report that hepatic unconventional prefoldin RPB5 interactor (URI) couples nutrient surpluses to inflammation and non-alcoholic steatohepatitis (NASH), a common cause of HCC. URI-induced DNA damage in hepatocytes triggers inflammation via T helper 17 (Th17) lymphocytes and interleukin 17A (IL-17A). This induces white adipose tissue neutrophil infiltration mediating insulin resistance (IR) and fatty acid release, stored in liver as triglycerides, causing NASH. NASH and subsequently HCC are prevented by pharmacological suppression of Th17 cell differentiation, IL-17A blocking antibodies, and genetic ablation of t…

Male0301 basic medicineCancer ResearchCarcinoma HepatocellularInflammationWhite adipose tissueDiet High-FatMice03 medical and health sciencesNon-alcoholic Fatty Liver DiseasemedicineAnimalsHumansUnconventional prefoldin RPB5 interactorbiologyInterleukin-17Liver NeoplasmsFatty liverIntracellular Signaling Peptides and ProteinsCell Biologymedicine.diseasedigestive system diseasesGene Expression Regulation NeoplasticRepressor Proteins030104 developmental biologyNeutrophil InfiltrationOncologyHepatocellular carcinomaImmunologybiology.proteinTh17 CellsInterleukin 17SteatosisSteatohepatitismedicine.symptomDNA DamageCancer Cell
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CKD NUTRITION, INFLAMMATION AND OXIDATIVE STRESS

2014

Introduction and Aims: Serum p-cresyl sulfate associates with cardiovascular disease in patients at different stages of chronic kidney disease. p-Cresyl sulfate concentrations are determined by intestinal uptake of p-cresol, human metabolism to p-cresyl sulfate and renal clearance. Whether intestinal uptake of p-cresol itself is associated with cardiovascular disease in patients with renal disease has not been studied to date. Methods: We performed a prospective study in patients with chronic kidney disease stage 1-5 (clinicaltrials.gov NCT00441623). Intestinal uptake of p-cresol, under steady state conditions, was estimated from 24h urinary excretion of p-cresyl sulfate. Primary endpoint w…

Transplantationmedicine.medical_specialtyFramingham Risk ScoreCardiovascular Historybusiness.industryHazard ratioRenal functionmedicine.diseaseGastroenterologyEndocrinologyNephrologyDiabetes mellitusInternal medicinemedicineMyocardial infarctionProspective cohort studybusinessKidney diseaseNephrology Dialysis Transplantation
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