6533b861fe1ef96bd12c579f
RESEARCH PRODUCT
CKD NUTRITION, INFLAMMATION AND OXIDATIVE STRESS
Abdelouahed KhalilAnteo Di NapoliStephen ZewingerMariusz FlisińskiDomenico TrimboliMaurizio BossolaMarina BiagioliOdile AzoulayOdile AzoulayMichele BuemiPiergiorgio BolascoAndreea IlyesÁNgeles ÁLvarezValeria CernaroPolichronis AlivanisGabriel StefanMehmet HaberalMarcelo Costa BatistaJerzy ChudekMujdat Batur CanozBranka MiticAbdul Rashid QureshiAnna StefańskaChristiaan L. MeuweseChristiaan L. MeuweseAnna KamińskaVera JankowskiYeon Soon JungLuisa SereniRafał DonderskiHo Sik ShinCiprian StoicaPeter StenvinkelInsa E. EmrichRosanna CoppoBoris ZingermanBoris ZingermanRachid SaileSonja RadenkovicYener KocIlona Miśkowiec-wiśniewskaTatjana CvetkovicDanilo FliserGrigore DogaruSimonetta PalleschiMilica BozicUrszula Spiechowicz-zatońKevin J. WoollardSerpil NebioğluErik W. HolyHark RimAbdul Rashid QureshiMahmut GokAdriana ArenaIryna DudarGoran PaunovicElvira FernándezMaria Inês Barreto-silvaJacek ManitiusNaohito IsoyamaNaohito IsoyamaDemet YavuzMichael BöhmJose M. ValdivielsoPaolo Maria GhezziSilvia Regina ManfrediPaweł StróżeckiYusuf OguzMaria L LusiniMiomir StojanovicGabriel MircescuMikio SuganoPaula Maria GligaZeynep BalMirela Liana GligaElisa LoiaconoHilmi Umut ÜNalViktoria AlekseevaSun Chul KimHyun Yul RhewJosé Tarcísio Giffoni De CarvalhoFoteini LamprianouEkrem KaraSang-kyung JoBarbara E. StähliAbdulkadir UnsalFrancesco FrancoMurat KaramanShunsuke GotoSumie GotoRichard J. JohnsonTamer SakaciChristophe DuboisRoman JunikNikolaos KarvouniarisNikitas MoschosTimo SpeerKathleen ClaesMaria Teresa IngegneriGunnar H. HeinePieter EvenepoelZahava GamzoJuan Jesus CarreroKeiji KonoBertrand GondouinSylwia RotkegelMehmet KanbaySebahattin SariRoxanne DarboussetShinichi NishiAndrzej BrymoraBahar Gurlek DemirciVincenzo BellizziJoanna SiódmiakDomenico Di LalloYe Na KimLatife Atasoy KarakasAdam M. ZawadaAlexander AkhmedovMustafa SevincTuncay SahutogluHrvoje CvijaGiovanni G. CamiciAyse C AkbasliMahmut I YilmazChristos PaliourasKarolina PaunovicBulent ErbayCarla Cavalheiro Da Silva LemosFrances Costa-silvaMarina DavoliLiesbeth ViaeneFatma Nurhan OzdemirMehtap Erkmen UyarKentaro NakaiAdrian CovicDanijela TasicJarosław CiepałMauro AttiGunnar HeineStéphane BurteyDomenico SantoroBenaya Rozen-zviBenaya Rozen-zviSimone VargasLucia RohrerGaetano MontaltoHakki CetinkayaTuran ColakBert BammensAlessandro AmoreTayfun EyiletenPaul LeursLiliana ViasuTheodoros HaviatsosYalcin SolakAntonino SidotiCarmen De PabloTayfun EyietenVincenzo SavicaMaria Dolores Sanchez-niñoYasemin Gulcan KurtGordana KocicJoachim JankowskiAndrea PisacaneKatarzyna WyskidaKenan KevenSunna SnaedalZorica DimitrijevicNikolaos PapagiannisAbdülgaffar VuralTaner BasturkMutlu SaglamBjörn AnderstamHilmi Umut UnalSerena ChiccaAline Trevisan PeresMaria Eugênia Fernandes CanzianiAlberto OrtizMahmut Ilker YilmazBengt LindholmStéphane PoitevinKiryong ParkPaolo M. GhezziAntonio PisaniMarialuisa CaiazzoNoreddine GhalimViktor KrotSilvia LucisanoMaria Aparecida DalboniEleonora RiccioSarah SeilerGiorgos NtetskasOskar SvedbergCarmela AloisiSangeon GwooPeter BárányMaria Bożentowicz-wikarekAlpaslan AltunogluO.m. LobodaElbis AhbapDariusz KleinTuncer CayciSiren SezerRosaria LupicaGiuseppe VitaRuben PoesenBjörn MeijersNagba Yendoubé GbandjabaMagdalena Olszanecka-glinianowiczBurak SayinWon Yong ChoBeata Marie Redublo QuintoJ. J. CarreroYuriko YonekuraFelix C. TannerMiguel CendorogloOlof HeimbürgerCuneyt AkgolPaola MichelozziSarah TriemYoshiharu ItoEmanouil AnastasakisGrażyna Odrowa˛ż-sypniewskaCaren Cristina GrabulosaAniceta BrzozowskaHyung Kyu KimMarek KretowiczMaria Inês Barreto SilvaThereza Christina Barja-fidalgoYusuke YamashitaHideki FujiiSimona StancuLuigi TazzaGiuseppe PalladinoNilufer BayraktarRachel BregmanRahman YavuzCengizhan AcikelBarbara RossiCristina CapusaMassimo SabbatiniMyung Gyu KimGuido BellinghieriRenata De Souza MendesDorin TartaRadmila Veličković-radovanovićKyrill S. RogacevKostantinos RoufasThomas F. Lüschersubject
Transplantationmedicine.medical_specialtyFramingham Risk ScoreCardiovascular Historybusiness.industryHazard ratioRenal functionmedicine.diseaseGastroenterologyEndocrinologyNephrologyDiabetes mellitusInternal medicinemedicineMyocardial infarctionProspective cohort studybusinessKidney diseasedescription
Introduction and Aims: Serum p-cresyl sulfate associates with cardiovascular disease in patients at different stages of chronic kidney disease. p-Cresyl sulfate concentrations are determined by intestinal uptake of p-cresol, human metabolism to p-cresyl sulfate and renal clearance. Whether intestinal uptake of p-cresol itself is associated with cardiovascular disease in patients with renal disease has not been studied to date. Methods: We performed a prospective study in patients with chronic kidney disease stage 1-5 (clinicaltrials.gov NCT00441623). Intestinal uptake of p-cresol, under steady state conditions, was estimated from 24h urinary excretion of p-cresyl sulfate. Primary endpoint was time to first cardiovascular event, i.e. cardiac death, myocardial infarction/ischemia, ventricular arythmia, cardiovascular surgery, cerebrovascular accident or symptomatic peripheral arterial disease. Statistical analysis was done using Kaplan Meier estimates and Cox proportional hazard analyses. Results: In a cohort of 200 patients, median 24h urinary excretion of p-cresyl sulfate was 457.47 µmol (IQR 252.68-697.17). After a median follow-up of 52 months, 25 patients reached the primary endpoint (tertile 1/2/3: 5/6/14 events, log rank P 0.0368, see figure). Higher urinary excretion of p-cresyl sulfate was related with cardiovascular events (univariate hazard ratio per 100 µmol increase: 1.112, P 0.0015). In multivariate analysis, urinary excretion of p-cresyl sulfate remained a predictor of cardiovascular events, independent of markers of renal function (Hazard ratio 1.120, P 0.0022) and in different models with other cardiovascular risk factors (Framingham risk factors, cardiovascular history, diabetes mellitus and biochemical parameters). The independent association between urinary excretion of p-cresyl sulfate and outcome persisted after correction for serum p-cresyl sulfate. Conclusions: Intestinal uptake of p-cresol associates with cardiovascular disease independent of renal function. Insights into mechanisms governing intestinal generation and absorption of p-cresol may lead to identification of novel therapeutic targets to reduce cardiovascular disease risk in patients with chronic kidney disease.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-05-01 | Nephrology Dialysis Transplantation |