Multicenter Phase II Study of Lurbinectedin in BRCA-Mutated and Unselected Metastatic Advanced Breast Cancer and Biomarker Assessment Substudy

Purpose This multicenter phase II trial evaluated lurbinectedin (PM01183), a selective inhibitor of active transcription of protein-coding genes, in patients with metastatic breast cancer. A unicenter translational substudy assessed potential mechanisms of lurbinectedin resistance. Patients and Methods Two arms were evaluated according to germline BRCA1/2 status: BRCA1/2 mutated (arm A; n = 54) and unselected ( BRCA1/2 wild-type or unknown status; arm B; n = 35). Lurbinectedin starting dose was a 7-mg flat dose and later, 3.5 mg/m2 in arm A. The primary end point was objective response rate (ORR) per Response Evaluation Criteria in Solid Tumors (RECIST). The translational substudy of resist…

Happiness in advanced adulthood and the elderly

The purpose of this study was to critically analyse the role that positive emotions, flourishing and mindfulness have among the elderly. It was explored how these concepts can contribute to successful aging and higher levels of happiness in this population. To this end, we conducted a non-experimental correlational study with 329 participants, aged from 55 to 98 years. Questionnaires were used to collect data through the following instruments: a socio-demographic questionnaire, Mindful Attention Awareness Scale (MAAS), Satisfaction With Life Scale (SWLS) and PANAS (Positive and Negative Affect Schedule), FS (Flourishing scale), PST (Positivity test), MHI-5 (Mental Health Inventory -- 5).

El nuevo escenario de la regulación de la estiba y desestiba portuaria en el ordenamiento jurídico español

A auto-eficácia na adaptação aos desafios do envelhecimento

Este artigo aborda a problemática do envelhecimento com qualidade de vida e bem-estar, estudada no contexto de adultos portugueses que frequentam Universidades Seniores em Portugal. Pretende-se especificamente, numa análise exploratória, conhecer a perceção da auto-eficácia na compreensão do bem-estar e qualidade de vida destas pessoas, através do construto de bem-estar subjetivo (BES). Para o efeito, foi realizado um trabalho empírico de natureza não experimental correlacional, que abrangeu 214 alunos de 7 Universidades Seniores portuguesas, com idades compreendidas entre os 51 e 86 anos, média de 68,26 anos. Os dados foram recolhidos por questionário, através dos seguintes instrumentos: q…