0000000000084156
AUTHOR
Christel Weiss
showing 3 related works from this author
Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted
2006
Abstract Tumours ferment glucose to lactate even in the presence of oxygen (aerobic glycolysis; Warburg effect). The pentose phosphate pathway (PPP) allows glucose conversion to ribose for nucleic acid synthesis and glucose degradation to lactate. The nonoxidative part of the PPP is controlled by transketolase enzyme reactions. We have detected upregulation of a mutated transketolase transcript (TKTL1) in human malignancies, whereas transketolase (TKT) and transketolase-like-2 (TKTL2) transcripts were not upregulated. Strong TKTL1 protein expression was correlated to invasive colon and urothelial tumours and to poor patients outcome. TKTL1 encodes a transketolase with unusual enzymatic prop…
Aktive Muskeldehntestung der ischiocruralen Muskulatur: Referenzwerte und Einflussfaktoren
2013
Einleitung: Eine verminderte Dehnfahigkeit der ischiocruralen Muskulatur fuhrt zu einem erhohten Verletzungsrisiko. Ziel ist deshalb die Herstellung einer muskularen Balance. Der Active-Knee-Extension-Test (AKE) uberpruft die Dehnfahigkeit der ischiocruralen Muskulatur. Da die bislang verfugbaren „Referenzwerte“ einem Kollektiv von wenigen mannlichen Probanden entstammen, ist deren Aussagekraft nur eingeschrankt verwertbar. Ziel der vorliegenden Studie ist daher die Erhebung von Referenzwerten an einem grosen gemischtgeschlechtlichen Probandenkollektiv gesunder Fitnesssportler sowie die Ermittlung von Einflussfaktoren auf die aktive Dehnfahigkeit der ischiocruralen Muskulatur. Material und …
The Impact of Small Extracellular Vesicles on Lymphoblast Trafficking across the Blood-Cerebrospinal Fluid Barrier In Vitro.
2020
Central nervous System (CNS) disease in pediatric acute lymphoblastic leukemia (ALL) is a major concern, but still, cellular mechanisms of CNS infiltration are elusive. The choroid plexus (CP) is a potential entry site, and, to some extent, invasion resembles CNS homing of lymphocytes during healthy state. Given exosomes may precondition target tissue, the present work aims to investigate if leukemia-derived exosomes contribute to a permissive phenotype of the blood-cerebrospinal fluid barrier (BCSFB). Leukemia-derived exosomes were isolated by ultracentrifugation from the cell lines SD-1, Nalm-6, and P12-Ichikawa (P12). Adhesion and uptake to CP epithelial cells and the significance on sub…