0000000000084653

AUTHOR

Gottfried Spangler

showing 2 related works from this author

Dopamine D4 receptor exon III polymorphism, adverse life events and personality traits in a nonclinical German adult sample.

2010

Personality and temperament embrace a wide area of both psychological and behavioral processes which are also based on disposition. A functional polymorphism in exon III of the dopamine D4 receptor gene (DRD4) has been a highly suspect genetic marker for personality in spite of ambiguous results. The present study aimed to further elucidate the relationship between DRD4, negative life events and personality in a representative nonclinical sample. Hundred sixty-seven Germans completed the NEO Five-Factor Inventory, the Tridimensional Personality Questionnaire and the California Adult Q-Sort. A factor analysis revealed 3 factors: emotional stability, social orientation and impulsivity. DNA fr…

AdultMalemedicine.medical_specialtyGenotypemedia_common.quotation_subjectMedizinische Fakultät -ohne weitere Spezifikation--Minisatellite RepeatsImpulsivityPersonality AssessmentWhite PeopleTridimensional Personality QuestionnaireLife Change EventsGermanymental disordersmedicinePersonalityHumansddc:610AlleleBig Five personality traitsPsychiatryBiological PsychiatryAllelesmedia_commonSex CharacteristicsPolymorphism GeneticReceptors Dopamine D4ExonsMiddle AgedPsychiatry and Mental healthNeuropsychology and Physiological PsychologyTemperamentFemalemedicine.symptomPersonality Assessment InventoryPsychologyClinical psychologySex characteristicsPersonalityNeuropsychobiology
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Adult attachment and gene polymorphisms of the dopamine D4 receptor and serotonin transporter (5-HTT).

2010

Recently, the Dopamine D4 Receptor Gene (DRD4) and the Serotonin Transporter Gene (5-HTT) have been found to be candidate genes for infant attachment disorganization. The present study aimed to explore the relationship of these genes to adult attachment representations. The Adult Attachment Interview was used to assess attachment representations in 167 German adults. DNA from buccal cells was genotyped for the DRD4 VNTR Exon III and 5-HTT LPR polymorphisms with respect to the presence of the 7repeat allele and the short allele, respectively. DRD4 7repeat allele carriers were significantly more likely to be securely attached than those without 7repeat but only for subjects with unloving care…

AdultMalemedicine.medical_specialtyCandidate geneGenotypePsychometricsStatistics as TopicExonDopamineRisk Factorsmental disordersInterview PsychologicalDevelopmental and Educational PsychologymedicineAttachment theoryHumansAllelePsychiatryGeneSerotonin transporterRetrospective StudiesGeneticsSerotonin Plasma Membrane Transport ProteinsPolymorphism GeneticbiologyReceptors Dopamine D4Middle AgedObject AttachmentPsychiatry and Mental healthCross-Sectional StudiesPhenotypebiology.proteinFemalePsychologyAttachment measuresmedicine.drugAttachmenthuman development
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