0000000000085200
AUTHOR
A. Cohen
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data
Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the genetic architecture of the trait remains largely unknown. The recent development of machine learning (ML) approaches incited us to apply them to classify healthy and diseased people according to their genomic information. The Immunochip dataset containing 18,227 CD patients and 34,050 healthy controls enrolled and genotyped by the international Inflammatory Bowel Disease genetic consortium (IIBDGC) has been re-analyzed using a set of ML methods: penalized logistic regression (LR), gradient boosted trees (GBT) and artificial neural ne…
Numerical Analysis of Word Frequencies in Artificial and Natural Language Texts
We perform a numerical study of the statistical properties of natural texts written in English and of two types of artificial texts. As statistical tools we use the conventional Zipf analysis of the distribution of words and the inverse Zipf analysis of the distribution of frequencies of words, the analysis of vocabulary growth, the Shannon entropy and a quantity which is a nonlinear function of frequencies of words, the frequency "entropy". Our numerical results, obtained by investigation of eight complete books and sixteen related artificial texts, suggest that, among these analyses, the analysis of vocabulary growth shows the most striking difference between natural and artificial texts…