0000000000085548
AUTHOR
H.
Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins.
Human Hsp60 chaperonin and its bacterial homolog GroEL, in association with the corresponding co-chaperonins Hsp10 and GroES, constitute important chaperone systems promoting the proper folding of several mitochondrial proteins. Hsp60 is also currently described as a ubiquitous molecule with multiple roles both in health conditions and in several diseases. Naïve Hsp60 bearing the mitochondrial import signal has been recently demonstrated to present different oligomeric organizations with respect to GroEL, suggesting new possible physiological functions. Here we present a combined investigation with circular dichroism and small-angle X-ray scattering of structure, self-organization, and sta…
Academic domains as political battlegrounds: A global enquiry by 99 academics in the fields of education and technology
WOS: 000401148100005
EVpedia: a community web portal for extracellular vesicles research
Abstract Motivation: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging. Results: We present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more tha…
Search for gamma ray bursts with the ARGO-YBJ detector in scaler mode
We report on the search for Gamma Ray Bursts (GRBs) in the energy range 1-100 GeV in coincidence with the prompt emission detected by satellites using the Astrophysical Radiation with Ground-based Observatory at YangBaJing (ARGO-YBJ) air shower detector. Thanks to its mountain location (Yangbajing, Tibet, P.R. China, 4300 m a.s.l.), active surface (about 6700 m**2 of Resistive Plate Chambers), and large field of view (about 2 sr, limited only by the atmospheric absorption), the ARGO-YBJ air shower detector is particularly suitable for the detection of unpredictable and short duration events such as GRBs. The search is carried out using the "single particle technique", i.e. counting all the …
The ARGO-YBJ experiment in Tibet
The setting up of the ARGO detector at the YangBaJing Cosmic Ray Laboratory (4300 m a.s.l., Tibet, P.R. China) has been completed during the last spring (2007). It consists of a central carpet made of 130 identical sub-units of 12 RPCs each (a "cluster"), covering a surface of about 5800 m2 with 93% active area, and a guard ring of 24 further clusters of the same type surrounding the central carpet with a lower sampling density. Signals are picked up by external electrodes of small size, thus allowing the sampling of EAS with high space-time granularity. Shower events are detected at a trigger rate of about 4 kHz. Events with a few particles detected by a single cluster are counted in scale…
Family reunification: the case of the Muslim migrant children in Europe
Adopting a child is not a legal concept recognized in Islamic law, who however giving a great importance to orphans and children's rights, has introduced the legal institute of the "Kafala". This institute can be defined as a commitment by the "kafil" to ensure maintenance, education and protection of a minor "makfoul" until his legal majority, in the same way as would a father to his son, but without creating any family relationship. For these reasons the “Kafala” can not be compared to an international adoption, which, contrariwise, entails the creation of a parent-child relationship. If, in one side the Kafala is a legal concept recognized by International Law, in particular by the Unite…
International Law, War and Human Rights: The Humanitarian Response
One of the most important issues in the international political and legal system comprises the interaction between human rights and humanitarian law. In particular, the separate treatment of such areas of law allows to delineate different contents and application procedures, while the joint consideration is not simple, in view of the reasons for which each of the two has been created. Humanitarian law is a set of rules of conduct limited to a political and legal situation pathological, and presumably temporary. Against this regulatory system, the international law of human rights is the establishment of a political and legal concept of man as endowed with certain inalienable rights that con…