0000000000086341
AUTHOR
Guillermo Martin
Near IR stationary wave Fourier transform lambda meter in lithium niobate: multiplexing and improving optical sampling using spatially shifted nanogroove antenna
Several integrated optics solutions currently exist to develop monolithic, robust, and lightweight high-resolution spectrometers for spatial applications. An interesting option is generating a stationary wave inside a single-mode waveguide, and sampling the interference fringes using dielectric discontinuities on the surface of the waveguide. This allows the recording of the signal on a detector on top of the waveguide, and using dedicated Fourier transform methods to recover the spectrum of the source. All the difficulty is then linked to the length of the interferogram that is sampled. This determines the spectral resolution and the spacing between sampling centers, which are ultimately l…
Tumor lysis syndrome in patients with acute myeloid leukemia: identification of risk factors and development of a predictive model
Background Despite the prophylactic use of allopurinol, tumor lysis syndrome (TLS)- related morbidity and mortality still occur in a number of patients with acute myeloid leukemia (AML).The aim of this study was: (i) to analyze the incidence and outcome of TLS in a large series of patients with AML receiving hyperhydration and allopurinol, (ii) to identify risk factors for TLS, and (iii) to develop a prognostic scoring system for estimating individual risk of TLS. Design and Methods The study included 772 adult patients with AML receiving induction chemotherapy between 1980 and 2002. TLS was divided into laboratory TLS (LTLS) or clinical TLS (CTLS).The population study was randomly divided …
Improving the vertical radiation pattern issued from multiple nano-groove scattering centers acting as an antenna for future integrated optics Fourier transform spectrometers in the near IR
The stationary wave integrated Fourier transform spectrometer (SWIFTS) is based on the sampling of a stationary wave using nano-scattering centers on the surface of a channel waveguide. Single nano-scale scattering centers above the waveguide surface will radiate the sampled signal with wide angular distribution, which is not compatible with the buried detection area of infrared (IR) detectors, resulting in crosstalk between pixels. An implementation of multiple diffraction nano-grooves (antenna) for each sampling center is proposed as an alternative solution to improve directivity towards the detector pixel by narrowing the scattering angle of the extracted light. Its efficiency is demonst…
Significance of increased blastic-appearing cells in bone marrow following myeloablative unrelated cord blood transplantation in adult patients.
An abnormal increase of nonleukemic blastic-appearing lymphocytes in bone marrow (BM) specimens has been reported after unrelated cord blood transplantation (UCBT). This study analyzed the incidence, chronology, biological features, and clinical significance of elevated numbers of these cells in a series of 165 consecutive adult patients demonstrating myeloid engraftment after myeloablative UCBT in a single institution. The patients' BM samples were routinely evaluated by cytomorphology at different time points after UCBT. When ≥5% of blastic-appearing cells were detected by cytomorphology in the BM, samples were also evaluated by multiparametric flow cytometry to characterize these cells. …