Is physician assessment of alcohol consumption useful in predicting risk of severe liver disease among people with HIV and HIV/HCV co-infection?

AbstractBackgroundAlcohol consumption is a known risk factor for liver disease in HIV-infected populations. Therefore, knowledge of alcohol consumption behaviour and risk of disease progression associated with hazardous drinking are important in the overall management of HIV disease. We aimed at assessing the usefulness of routine data collected on alcohol consumption in predicting risk of severe liver disease (SLD) among people living with HIV (PLWHIV) with or without hepatitis C infection seen for routine clinical care in Italy.MethodsWe included PLWHIV from two observational cohorts in Italy (ICONA and HepaICONA). Alcohol consumption was assessed by physician interview and categorized ac…

Virological response and retention in care according to time of starting ART in Italy: data from the Icona Foundation Study cohort

Abstract Objectives To describe: (i) factors associated with rapid and delayed ART initiation; (ii) rates of 12 week virological response; and (iii) virologically controlled retention in care by 1 year from ART initiation according to timing of start in a real-life setting. Methods All individuals in the Icona cohort diagnosed with HIV in 2016–17 who initiated ART were grouped according to the time between HIV diagnosis and ART initiation: Group 1, ≤7 days; Group 2, 8–14 days; Group 3, 15–30 days; Group 4, 31–120 days; and Group 5, >120 days. Multivariable logistic regression models were used to identify factors associated with: (i) the probability of rapid (Group 1) and very delayed…

At the intersection of cultural and natural heritage: Distribution and conservation of the type localities of Italian endemic vascular plants

Abstract We conducted a GIS spatial analysis with the aim of providing the first quantitative large-scale overview of the distribution patterns of 1536 type localities ( loci classici ) of 1216 Italian endemic vascular plants and their relationship with a set of descriptive variables. Whereas some variables were used to model the presence-absence distribution patterns of the type localities for the whole set of endemics as well as for the subset of narrow endemics, others (e.g., presence inside or outside protected areas and Italian Important Plant Areas) were considered with the purpose of assessing potential assets or risks for conservation. The largest number of type localities was found…

1, 10, 100, how many floristic databases are there in Italy?

The Group for Floristics of the Italian Botanical Society (SBI) prepared a questionnaire to be distributed among all those concerned. On the whole about three dozens feedbacks were collected and analysed.

Are Red Lists really useful for plant conservation? The New Red List of the Italian Flora in the perspective of national conservation policies

La nuova Lista Rossa della flora Italiana comprende tutte le "policy" specie italiane e altre specie di nota conservazione e comprende 400 taxa di cui il 65% sono minacciate di estinzione. La Lista Rossa si basa su un enorme data-set georeferenziato utile per gli scopi di conservazione. - The New Red List of the Italian Flora includes all the Italian policy species and other species of known conservation concerns for a total of 400 taxa, 65% of which are threatened with extinction. The Red List is based on a huge georeferenced data-set useful for conservation purposes. -

Red Listing plants under full national responsibility: Extinction risk and threats in the vascular flora endemic to Italy

Abstract Taxa endemic to a country are key elements for setting national conservation priorities and for driving conservation strategies, since their persistence is entirely dependent on national policy. We applied the IUCN Red List categories to all Italian endemic vascular plants (1340 taxa) to assess their current risk of extinction and to highlight their major threats. Our results revealed that six taxa are already extinct and that 22.4% (300 taxa) are threatened with extinction, while 18.4% (247; especially belonging to apomictic groups) have been categorized as Data Deficient. Italian endemic vascular plants are primarily threatened by natural habitat modification due to agriculture, …

Notulae to the Italian native vascular flora: 1

In this contribution, new data concerning the Italian distribution of native vascular flora are presented. It includes new records, exclusions, and confirmations pertaining to the Italian administrative regions for taxa in the genera Arundo, Bromopsis, Cistus, Crocus, Festuca, Galeopsis, Genista, Lamium, Leucanthemum, Nerium, Orobanche, Peucedanum, Pilosella, Polycnemum, Stipa and Viola.

Risk for non-AIDS-defining and AIDS-defining cancer of early versus delayed initiation of antiretroviral therapy

BACKGROUND: Immediate initiation of antiretroviral therapy (ART) regardless of CD4 cell count reduces risk for AIDS and non-AIDS-related events in asymptomatic, HIV-positive persons and is the standard of care. However, most HIV-positive persons initiate ART when their CD4 count decreases below 500 × 10 9 cells/L. Consequences of delayed ART on risk for non-AIDS-defining and AIDS-defining cancer, one of the most common reasons for death in HIV, are unclear. OBJECTIVE: To estimate the long-term risk difference for cancer with the immediate ART strategy.DESIGN: Multinational prospective cohort study.SETTING: The D:A:D (Data collection on Adverse events of anti-HIV Drugs) study, which included…

An inventory of the names of native, non-endemic vascular plants described from Italy, their loci classici and types

The census of the loci classici of 1,227 native, non-endemic vascular plants described from Italy is here presented and described. The effective place of publication of accepted names, basionyms and homotypic synonyms were identified and critically verified. The geographic information on the loci classici was excerpted from the protologues, as well as information on typification for the taxa described before 1 January 1958. The names without a holotype are 1,165. For 591 names a lecto- or neo-typification is available in literature, while 572 currently accepted taxa still need a type designation. For ten of these names showing previous ineffective typification, nomenclatural types are desig…

A novel use of type 1 collagen gels in determinino the metastatic potential of tumor cells

The impact of DAA-mediated HCV eradication on CD4+ and CD8+ T lymphocyte trajectories in HIV/HCV coinfected patients: Data from the ICONA Foundation Cohort

HCV infection has been hypothesized as a contributor of poor CD4+ recovery in patients living with HIV (PLWHIV). Aim of this study was to evaluate CD4+, CD8+ cells and CD4/CD8 ratio trends before and after HCV treatment with direct acting agents (DAA) in PLWHIV. HIV/HCV patients enrolled in ICONA and HepaICONA cohorts with HIV-RNA≤50 copies/ml who achieved a sustained viral response after DAA treatment were studied. A linear regression model was used to investigate CD4+, CD8+ and CD4/CD8 changes 12 months before and after DAA treatment. A total of 939 HIV/HCV patients were included, 225 (24.0%) female, median age: 53 years (IQR 50–56). At DAA initiation, CD4+ T cell count was <350 cells/…

Human Immunodeficiency Virus Continuum of Care in 11 European Union Countries at the End of 2016 Overall and by Key Population: Have We Made Progress?

Abstract Background High uptake of antiretroviral treatment (ART) is essential to reduce human immunodeficiency virus (HIV) transmission and related mortality; however, gaps in care exist. We aimed to construct the continuum of HIV care (CoC) in 2016 in 11 European Union (EU) countries, overall and by key population and sex. To estimate progress toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 target, we compared 2016 to 2013 estimates for the same countries, representing 73% of the population in the region. Methods A CoC with the following 4 stages was constructed: number of people living with HIV (PLHIV); proportion of PLHIV diagnosed; proportion of those diagnosed …

Nouvelle utilisation du Collagène de Type I dans la Détermination du potentiel metastatique des Cellules Tumorales : Etude Morphologique et Biochimique

Loci classici delle piante vascolari endemiche italiane descritte per la Puglia

loci classici of the Italian endemic vascular plants described for Apulia -.the italian endemic vascular plants described for apulia Region are presented. altogether, 66 italian endemics have their locus classicus in apulia, including 9 taxa whose protologues cite several localities, both in apulia and in other Regions.

An updated checklist of the vascular flora native to Italy

AbstractAn updated inventory of the vascular flora alien to Italy, providing details on the occurrence at regional level, is presented. The checklist includes 1597 species, subspecies, and hybrids, distributed in 725 genera and 152 families; 2 taxa are lycophytes, 11 ferns and fern allies, 33 gymnosperms, and 1551 angiosperms. 157 taxa are archaeophytes and 1440 neophytes. The alien taxa currently established in Italy are 791 (570 naturalized and 221 invasive), while 705 taxa are casual aliens, 4 are not assessed, 7 are of unknown regional distribution, 47 have not been confirmed in recent times, 3 are considered extinct or possibly extinct in the country, and 40 are doubtfully occurring in…

An updated checklist of the vascular flora alien to Italy

An updated inventory of the vascular flora alien to Italy, providing details on the occurrence at regional level, is presented. The checklist includes 1597 species, subspecies, and hybrids, distributed in 725 genera and 152 families; 2 taxa are lycophytes, 11 ferns and fern allies, 33 gymnosperms, and 1551 angiosperms. 157 taxa are archaeophytes and 1440 neophytes. The alien taxa currently established in Italy are 791 (570 naturalized and 221 invasive), while 705 taxa are casual aliens, 4 are not assessed, 7 are of unknown regional distribution, 47 have not been confirmed in recent times, 3 are considered extinct or possibly extinct in the country, and 40 are doubtfully occurring in Italy. …

Switching to dual/monotherapy determines an increase in CD8+ in HIV-infected individuals: An observational cohort study

Background The CD4/CD8 ratio has been associated with the risk of AIDS and non-AIDS events. We describe trends in immunological parameters in people who underwent a switch to monotherapy or dual therapy, compared to a control group remaining on triple antiretroviral therapy (ART). Methods We included patients in Icona who started a three-drug combination ART regimen from an ART-naïve status and achieved a viral load ≤ 50 copies/mL; they were subsequently switched to another triple or to a mono or double regimen. Standard linear regression at fixed points in time (12-24 months after the switch) and linear mixed model analysis with random intercepts and slopes were used to compare CD4 and CD8…

Towards a checklist of the Italian gypsophilous vascular flora.

The strict relationship between plants and particular types of substrate has long been known to botanists and plant ecologists who have dealt with this issue. The peculiar flora growing on Italian gypsum substrates has been underlined since the nineteenth century (1, 2, 3). The concept of plant gypsophily can be defined as the exclusiveness or marked preference for living on gypsum outcropping rocks. Thus, only those plant species which show preference, or even exclusivity, for gypsum substrates, should be classified as gypsophilous (4). The main aim of this research has been to provide a checklist of the Italian gypsophilous flora. The study was made possible through international collabor…

Notulae to the Italian native vascular flora: 7

In this contribution, new data concerning the distribution of native vascular flora in Italy are presented. It includes new records, confirmations and status changes to the Italian administrative regions for taxa in the generaAcer,Alchemilla,Andrachne,Bromus,Clinopodium,Colchicum,Damasonium,Erodium,Festuca,Hieracium,Hyparrhenia,Ipomoea,Linaria,Lolium,Narcissus,Ranunculus,Sisymbrium,Stipa,Valerianella,Vicia, andZannichellia. New combinations in the genusZiziphora(Z.sardoaandZ.corsica) and the new subspeciesUlmusminorsusbp.canescensare proposed. Furthermore, the name Calaminthaalpinavar.sardoa is here lectotypified. Nomenclatural and distribution updates, published elsewhere, and corrigenda a…

An inventory of the names of vascular plants endemic to Italy, their loci classici and types

The census of the loci classici of 1,400 Italian endemic vascular plants (i.e. not thriving elsewhere with the exception of Corsica and Malta) is here presented and described. The effective place of publication of accepted names, basionyms and homotypic synonyms were identified and critically verified. This often resulted in some change in authorship attribution and, in seven cases, in validation problems (Asperula cynanchica var. lactea var. nov., A. lactea comb. nov., Biscutella laevigata subsp. raffaelliana subsp. nov., Ferulago nodosa subsp. geniculata comb. & stat. nov., Limonium tineoi comb. nov., L. usticanum sp. nov., Noccaea torreana comb. nov.). The geographic information on t…

NON-NATIVE FLORA OF ITALY: SPECIES DISTRIBUTION AND THREATS

In this paper, we provide an overview of the distribution and invasive status of non-native species in the Italian flora across its administrative regions, biogeographic regions and main land use types, and a synthesis of current knowledge on the threats they pose within the country. The information on non-native plant species collected during the project oA survey of the non-native Italian florao was used to compile comprehensive regional and national databases. The number of non-native species within a given administrative region increases in proportion to its size, resident population density and latitude, reaching the highest values in the intensively cultivated, heavily industrialized …

Notulae to the Italian native vascular flora: 3

In this contribution new data concerning the distribution of native vascular flora in Italy are presented. It includes new records, exclusions, and confirmations to the Italian administrative regions for taxa in the generaAsplenium,Bolboschoenus,Botrychium,Chamaerops,Crocus,Galeopsis,Grafia,Helosciadium,Hieracium,Juniperus,Leucanthemum,Lolium,Medicago,Phalaris,Piptatherum,Potamogeton,Salicornia,Salvia,Seseli,Silene,Spiraea,TorilisandVicia.Rhaponticoidescalabricais proposed assynonym novumofR.centaurium. Furthermore, new combinations in the generaGalatellaandLactucaare proposed.

Inventory of the non‐native flora of Italy

In this paper we present a comprehensive inventory of the non‐native vascular flora of Italy, which was produced within the project “A survey of the Italian non‐native flora”, funded by the Italian Ministry for the Environment. Previously published floristic accounts were the main source of information. Historical records were critically revised and integrated with recent literature, data from herbaria and some unpublished information, so as to obtain a complete, up‐to‐date catalogue of the non‐native vascular plant species that occur spontaneously in Italy. The inventory lists 1023 non‐native species and subspecies, which account for 13.4% of all the Italian flora. The Italian non‐native f…

Red list of threatened vascular plants in Italy

Italy has a rich natural heritage, which is dangerously under pressure. In recent years, there is an increased awareness of the crucial role of plants in ecosystem functioning and in providing ecosystem services. Consequently, an updated Red List of the Italian vascular flora was compiled in this work, at the request of the Ministry for Environment, Land and Sea Protection, with the scientific support of the Italian Botanical Society. The IUCN Red List criteria were applied to 2,430 Italian native vascular plant taxa to assess their current extinction risk and to highlight the major threats affecting the Italian flora. Our results revealed that 54 taxa (2.2% of the assessed taxa) are extinc…

An updated checklist of the vascular flora native to Italy

An updated inventory of the native vascular flora of Italy, providing details on the occurrence at regional level, is presented. The checklist includes 8195 taxa (6417 species and 1778 subspecies), distributed in 1092 genera and 152 families; 23 taxa are lycophytes, 108 ferns and fern allies, 30 gymnosperms and 8034 angiosperms. The taxa currently occurring in Italy are 7483, while 568 taxa have not been confirmed in recent times, 99 are doubtfully occurring in the country and 19 are data deficient. Out of the 568 not confirmed taxa, 26 are considered extinct or possibly extinct.

An updated checklist of the vascular flora alien to Italy

An updated inventory of the vascular flora alien to Italy, providing details on the occurrence at regional level, is presented. The checklist includes 1597 species, subspecies, and hybrids, distributed in 725 genera and 152 families; 2 taxa are lycophytes, 11 ferns and fern allies, 33 gymnosperms, and 1551 angiosperms. 157 taxa are archaeophytes and 1440 neophytes. The alien taxa currently established in Italy are 791 (570 naturalized and 221 invasive), while 705 taxa are casual aliens, 4 are not assessed, 7 are of unknown regional distribution, 47 have not been confirmed in recent times, 3 are considered extinct or possibly extinct in the country, and 40 are doubtfully occurring in Italy. …