0000000000088245

AUTHOR

Cornel C. Sieber

showing 5 related works from this author

Effect of acetyl-l-carnitine in the treatment of diabetic peripheral neuropathy : A systematic review and meta-analysis

2017

Background/aim: Deficiency of acetyl-L-carnitine (ALC) and L-carnitine (LC) appears to play a role in peripheral diabetic neuropathy, although the evidence in humans is still limited. We conducted a systematic review and meta-analysis investigating the effect of ALC on pain and electromyographic parameters in people with diabetic neuropathy. Methods: A literature search in major databases, without language restriction, was undertaken. Eligible studies were randomized controlled trials (RCTs) or pre-and post-test studies. The effect of ALC supplementation on pain perception and electromyographic parameters in patients with diabetic neuropathy was compared vs. a control group (RCTs). The effe…

medicine.medical_specialtyDiabetic neuropathyDiabetePlaceboNerve conduction velocitylaw.inventionRATS03 medical and health sciencesGLUTAMATE0302 clinical medicineRandomized controlled triallawDiabetes mellitusMedicineQUALITYMeta-analysi030212 general & internal medicineUlnar nerveAdverse effectbusiness.industryDiabetesNERVE GROWTH-FACTORPAINmedicine.diseaseAcetyl-L-carnitine3. Good healthSurgeryNeuropathyAcetyl-L-carnitine; Diabetes; Meta-analysis; Neuropathy; Gerontology; Geriatrics and GerontologyMeta-analysisPeripheral neuropathyAnesthesia3121 General medicine internal medicine and other clinical medicineGeriatrics and GerontologybusinessGerontology030217 neurology & neurosurgeryCLINICAL-TRIALS
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Update on the ESCEO recommendation for the conduct of clinical trials for drugs aiming at the treatment of sarcopenia in older adults

2020

Abstract Background In 2016, an expert working group was convened under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and formulated consensus recommendations for the conduct of clinical trials for drugs to prevent or treat sarcopenia. Aims The objective of the current paper is to provide a 2020 update of the previous recommendations in accordance with the evidence that has become available since our original recommendations. Methods This paper is based on literature reviews performed by members of the ESCEO working group and followed up with face to face meetings organized for the whole group to make amendments and discuss…

AgingSarcopeniaGeriatrics & GerontologyStandardizationDiseaseReviewRecommendationsFace-to-face0302 clinical medicineQUALITY-OF-LIFEGAIT SPEEDClinical trial; Drug registration; Guidelines; Recommendations; Sarcopenia; Treatment; Aged; Humans; Muscle Strength; Osteoarthritis; Osteoporosis; Pharmaceutical Preparations; Sarcopenia030212 general & internal medicineMUSCLE MASSDIETARY-PROTEINClinical trialPhysical limitationsPharmaceutical Preparations/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingPatient-reported outcomeGRIP STRENGTHLife Sciences & Biomedicinemedicine.medical_specialtyNUTRITIONAL-STATUSBODY-COMPOSITION030209 endocrinology & metabolismGuidelines03 medical and health sciencesClinical trial · Sarcopenia · Guidelines · Recommendations · Drug registration · TreatmentSDG 3 - Good Health and Well-beingOsteoarthritismedicineHumansMuscle StrengthDrug registrationAgedScience & Technologybusiness.industryWORKING GROUPmedicine.diseaseComorbidityClinical trialTreatmentSarcopeniaPATIENT-REPORTED OUTCOMESPhysical therapyOsteoporosisGeriatrics and GerontologyPHYSICAL PERFORMANCEbusinessAging Clinical and Experimental Research
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Relation between muscle mass, motor units and type of training in master athletes.

2014

OBJECTIVE: The aim of this study was to measure the number of motor units and muscle mass in power-trained and endurance-trained master athletes compared with community-dwelling older adults. METHODS: Seventy-five master athletes (52 power- and 23 endurance-trained athletes) were recruited at the 2012 European Veteran Athletics Championships in Zittau (Germany). One hundred and forty-nine community-dwelling older adults served as controls. In all participants, the motor unit number index (MUNIX) in the hypothenar muscle and whole body muscle mass was determined by bioelectrical impedance analysis (BIA). RESULTS: In both male and female master athletes, there were significant negative correl…

AdultMalemedicine.medical_specialtyAgingmaster athletePhysiologymusclePhysical activityAthletic PerformanceMuscle masssarcopenia03 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitationEMGPhysiology (medical)medicineHumansta315Muscle SkeletalAgedAged 80 and overMotor NeuronsSex CharacteristicsbiologyAthletesbusiness.industryMotor unit numberta3141030229 sport sciencesGeneral MedicineOrgan SizeMiddle Agedmedicine.diseasebiology.organism_classificationWeak correlationageingSarcopeniaMuscle Fibers Fast-TwitchPhysical therapyPhysical EnduranceFemalebusinessHypothenar muscleBioelectrical impedance analysis030217 neurology & neurosurgeryMUNIXPhysical Conditioning HumanClinical physiology and functional imaging
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Interest in meta-research in geriatric medicine: a survey of members of the European Geriatric Medicine Society

2020

To know the knowledge of the EuGMS members regarding meta-research, especially systematic reviews and meta-analyses. Interest in systematic reviews and meta-analyses is high and there is a demand for education on these topics in relation to geriatric medicine. We need more resources in the EuGMS for education for meta-research tailored for geriatric medicine. There has been an exponential increase in meta-research, especially in the branch dealing with systematic reviews [SRs] and meta-analyses [MAs]. However, the knowledge regarding these topics in geriatric medicine is still poorly explored. We therefore undertook a survey of the current knowledge and needs in meta-research in geriatrics.…

MaleResearch Reportmedicine.medical_specialty2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)EuGMSSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)meta-research03 medical and health sciences0302 clinical medicineMeta researchGermanySurveys and QuestionnairesMedicine and Health SciencesmedicineMeta-analysis Systematic review Questionnaire EuGMSHumanssurvey030212 general & internal medicineAgedGeriatricsa survey of members of the European Geriatric Medicine Society- EUROPEAN GERIATRIC MEDICINE 2020 [Veronese N. Torbahn G. Demurtas J. Beaudart C. SOYSAL P. Marengoni A. Shenkin S. D. Petrovic M. Sieber C. C. Cherubini A. et al. -Interest in meta-research in geriatric medicine]030214 geriatricsgeriatric medicinebusiness.industryQuestionnaireEuropean Geriatric Medicine SocietyMiddle AgedClinical PracticeMeta-analysisSystematic reviewGeriatricsFamily medicineMeta-analysisEuGMS; Meta-analysis; Questionnaire; Systematic reviewSystematic reviewEuGMS; Meta-analysis; Questionnaire; Systematic review; Aged; Female; Germany; Humans; Male; Middle Aged; Research Report; Societies; Surveys and Questionnaires; GeriatricsFemalebusinessSocieties
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Sarcopenia and health-related outcomes: an umbrella review of observational studies

2019

Key summary pointsAimTo investigate associations of sarcopenia with adverse health-related outcomes, through an umbrella review method.FindingsSarcopenia appears to be significantly associated with several adverse outcomes in older people, with a strong evidence for increased risk of mortality, disability, and falls.MessageSarcopenia is associated with several adverse health-related outcomes in older people, indicating the need of assessing this condition in daily practice. AbstractBackgroundThe clinical relevance of sarcopenia has increasingly been recognized. However, whether it is associated with the development of other medical conditions is still unclear. Therefore, we aimed to capture…

GerontologySarcopeniaan umbrella review of observational studies- EUROPEAN GERIATRIC MEDICINE cilt.10 ss.853-862 2019 [Veronese N. Demurtas J. SOYSAL P. Smith L. Torbahn G. Schoene D. Schwingshackl L. Sieber C. Bauer J. Cesari M. et al. -Sarcopenia and health-related outcomes]Psychological intervention03 medical and health sciencesUmbrella review0302 clinical medicinemedicineFallClinical significanceMeta-analysi030212 general & internal medicineMortalityDisability030214 geriatricsbusiness.industryHealth relatedOdds ratiomedicine.diseaseConfidence intervalIncreased riskHealthSarcopeniaObservational studyRisk factorbusinesshuman activities
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