0000000000088275

AUTHOR

Antje Ziller

showing 4 related works from this author

Investigation of pH-Responsiveness inside Lipid Nanoparticles for Parenteral mRNA Application Using Small-Angle X-ray Scattering.

2020

Messenger ribonucleic acid (mRNA)-based nanomedicines have shown to be a promising new lead in a broad field of potential applications such as tumor immunotherapy. Of these nanomedicines, lipid-based mRNA nanoparticles comprising ionizable lipids are gaining increasing attention as versatile technologies for fine-tuning toward a given application, with proven potential for successful development up to clinical practice. Still, several hurdles have to be overcome to obtain a drug product that shows adequate mRNA delivery and clinical efficacy. In this study, pH-induced changes in internal molecular organization and overall physicochemical characteristics of lipoplexes comprising ionizable li…

In situPhospholipidNanoparticle02 engineering and technology010402 general chemistry01 natural sciencesDegree of ionizationchemistry.chemical_compoundElectrochemistryGeneral Materials ScienceRNA MessengerParticle SizeSpectroscopyChemistrySmall-angle X-ray scatteringX-RaysRNASurfaces and InterfacesHydrogen-Ion Concentration021001 nanoscience & nanotechnologyCondensed Matter PhysicsFluorescence0104 chemical sciencesMembraneBiophysicsNanoparticles0210 nano-technologyLangmuir : the ACS journal of surfaces and colloids
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Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA

2020

Cells 9(9), 2034 (1-19) (2020). doi:10.3390/cells9092034

0301 basic medicine570small angle scatteringNanoparticlecationic lipid02 engineering and technologyengineering.materialTransfectionArticleCell LineFatty Acids Monounsaturated03 medical and health sciencesMiceBiopolymersddc:570AnimalsHumansRNA MessengerParticle Sizelcsh:QH301-705.5chemistry.chemical_classificationMice Inbred BALB Ccancer immunotherapySmall-angle X-ray scatteringHeparinOptical ImagingCationic polymerizationGeneral MedicinePolymerTransfection021001 nanoscience & nanotechnologyvaccinationSmall-angle neutron scatteringLipidslipid-polymer hybrid nanoparticlesQuaternary Ammonium Compounds030104 developmental biologychemistrylcsh:Biology (General)cationic polymerBiophysicsengineeringNanoparticlesRNAFemalePolymer blendBiopolymer0210 nano-technologyCovid-19
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Investigation of charge ratio variation in mRNA – DEAE-dextran polyplex delivery systems

2019

Biomaterials 192, 612 - 620 (2019). doi:10.1016/j.biomaterials.2018.10.020

570Static ElectricityBiophysicsBioengineering02 engineering and technologyGene deliveryBiomaterials03 medical and health scienceschemistry.chemical_compoundDrug Delivery SystemsX-Ray DiffractionDynamic light scatteringddc:570Scattering Small AngleHumansRNA MessengerParticle Size030304 developmental biology0303 health sciencesMessenger RNAHeparinSmall-angle X-ray scatteringDEAE-DextranBiological activityDendritic CellsTransfection021001 nanoscience & nanotechnologySmall-angle neutron scatteringDextranchemistryMechanics of MaterialsCeramics and CompositesBiophysics0210 nano-technology
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Incorporation of mRNA in Lamellar Lipid Matrices for Parenteral Administration

2018

Molecular pharmaceutics 15(2), 642 - 651 (2018). doi:10.1021/acs.molpharmaceut.7b01022

0301 basic medicineModels MolecularDrug CompoundingKineticsLipid BilayersPharmaceutical Science610TransfectionCell LineMyoblasts03 medical and health sciencesMiceX-Ray DiffractionCationsDrug DiscoveryScattering Small AngleAnimalsRNA Messengerddc:610Lipid bilayerLuciferasesMessenger RNALiposomeDrug CarriersChemistryAqueous two-phase systemRNATransfection030104 developmental biologyDelayed-Action PreparationsLiposomesBiophysicsMolecular Medicinelipids (amino acids peptides and proteins)Drug carrier
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