0000000000088402
AUTHOR
Philippe Berger
Palladium-Catalyzed Hydroxycarbonylation of Aryl and Vinyl Bromides by Mixed Acetic Formic Anhydride
The palladium-catalyzed hydroxycarbonylation of aryl and vinyl bromides in the presence of acetic anhydride and lithium formate as a carbon monoxide source has been developed. The combination of palladium(II) acetate with 1,1'-bis(diphenylphosphino)ferrocene (dppf) is an efficient catalytic system when the reaction is carried out at 120 °C.
Evolution Over Time of Ventilatory Management and Outcome of Patients With Neurologic Disease
OBJECTIVES: To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality. DESIGN: Secondary analysis of three prospective, observational, multicenter studies. SETTING: Cohort studies conducted in 2004, 2010, and 2016. PATIENTS: Adult patients who received mechanical ventilation for more than 12 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among the 20,929 patients enrolled, we included 4,152 (20%) mechanically ventilated patients due to different neurologic diseases. Hemorrhagic stroke and brain trauma were the most common pathologies associated with the need fo…