0000000000092869

AUTHOR

X. Han

showing 37 related works from this author

Corrigendum to “Premature ovarian senescence and a high miscarriage rate impair fertility in women with HCV” [J Hepatol 68 (2018) 33–41](S01688278173…

2018

It has come to our attention that the PITER framework investigator, Alessandro Federico, was incorrectly listed as F. Alessandro in the original manuscript. Please note that the correct name of this author is Alessandro Federico (2nd University of Naples). The correct list of PITER investigators is in the footnote below.

HepatologyHepatitis B; EASL guidelines; Treatment; Interferon; Entecavir; Tenofovir; TAF; HBsAg; Hepatocellular carcinoma; HBV DNA; HBV reactivation; Mother to child transmissionHepatocellular carcinomaHBV reactivationEASL guidelinesHepatitis BEntecavirTreatmentHBsAgTAFHBV DNAMother to child transmissionInterferonTenofovirEASL guideline
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Increased mRNAs for procollagens and key regulating enzymes in rat skeletal muscle following downhill running.

1999

The purpose of the study was to investigate pre-translational regulation of collagen expression after a single bout of exercise. We analysed steady-state messenger ribonucleic acid (mRNA) levels for collagen types I, III and IV, alpha- and beta-subunits of prolyl 4-hydroxylase and lysyl oxidase (enzymes modifying procollagen chains), and enzyme activity of prolyl 4-hydroxylase from rat soleus muscle (MS) and the red parts of quadriceps femoris muscle (MQF) after 12 h and after 1, 2, 4, 7 and 14 days of downhill (-13.5 degrees ) treadmill running at a speed of 17 m.min-1 for 130 min. Histological and biochemical assays revealed exercise-induced muscle damage in MQF but not MS. Steady-state m…

medicine.medical_specialtyPhysiologyClinical BiochemistryPhysical ExertionProcollagen-Proline DioxygenaseLysyl oxidaseBiologyRunningProtein-Lysine 6-OxidaseHydroxyprolinechemistry.chemical_compoundType IV collagenPhysiology (medical)Internal medicineGene expressionmedicineAnimalsExertionRNA MessengerRats WistarMuscle SkeletalGlucuronidaseSoleus muscleSkeletal muscleBlotting NorthernRatsProcollagen peptidaseEndocrinologymedicine.anatomical_structurechemistryFemaleCollagenProcollagenPflugers Archiv : European journal of physiology
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First observation of the doubly charmed baryon decay Ξcc++→Ξc+π+

2018

The doubly charmed baryon decay Ξcc++→Ξc+π+ is observed for the first time, with a statistical significance of 5.9σ, confirming a recent observation of the baryon in the Λc+K−π+π+ final state. The data sample used corresponds to an integrated luminosity of 1.7 fb−1, collected by the LHCb experiment in pp collisions at a center-of-mass energy of 13 TeV. The Ξcc++ mass is measured to be 3620.6±1.5(stat)±0.4(syst)±0.3(Ξc+) MeV/c2 and is consistent with the previous result. The ratio of branching fractions between the decay modes is measured to be [B(Ξcc++→Ξc+π+)×B(Ξc+→pK−π+)]/[B(Ξcc++→Λc+K−π+π+)×B(Λc+→pK−π+)]=0.035±0.009(stat)±0.003(syst).

Particles and fieldGeneral Physics and Astronomy01 natural sciencesNONuclear physicsPhysics and Astronomy (all)Condensed Matter::Superconductivity0103 physical sciencesPhysicLHCb - Abteilung HintonSDG 7 - Affordable and Clean Energy010306 general physicsPhysics/dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy010308 nuclear & particles physicsHigh Energy Physics::PhenomenologyParticle physicsHEPBaryonLHCbCharmed baryonHadron colliderHigh Energy Physics::ExperimentB physics Branching fraction CP violation Hadron-Hadron scattering (experiments)LHCFísica de partículesExperiments
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First Observation ofD0−D¯0Oscillations inD0→K+π−π+π−Decays and Measurement of the Associated Coherence Parameters

2016

Charm meson oscillations are observed in a time-dependent analysis of the ratio of D0→K+π−π+π− to D0→K−π+π−π+ decay rates, using data corresponding to an integrated luminosity of 3.0fb−1 recorded by the LHCb experiment. The measurements presented are sensitive to the phase-space averaged ratio of doubly Cabibbo-suppressed to Cabibbo-favoured amplitudes rK3πD and the product of the coherence factor RK3πD and a charm mixing parameter y′K3π. The constraints measured are rK3πD=(5.67±0.12)×10−2, which is the most precise determination to date, and RK3πD⋅y′K3π=(0.3±1.8)×10−3, which provides useful input for determinations of the CP-violating phase γ in B±→DK±,D→K∓π±π∓π± decays. The analysis also …

PhysicsCoherence factorMeson010308 nuclear & particles physicsBranching fractionGeneral Physics and Astronomy01 natural sciencesStandard deviationNuclear physicsAmplitudePhase space0103 physical sciencesCP violationCoherence (signal processing)010306 general physicsPhysical Review Letters
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First Observation of Top Quark Production in the Forward Region

2015

Top quark production in the forward region in proton-proton collisions is observed for the first time. The W + b final state with W → μν is reconstructed using muons with a transverse momentum, p[subscript T], larger than 25 GeV in the pseudorapidity range 2.0 20  GeV. The results are based on data corresponding to integrated luminosities of 1.0 and 2.0  fb[superscript -1] collected at center-of-mass energies of 7 and 8 TeV by LHCb. The inclusive top quark production cross sections in the fiducial region are σ(top)[7  TeV] = 239 ± 53(stat) ± 33(syst) ± 24(theory)  fb, σ(top)[8  TeV] = 289 ± 43(stat) ± 40(syst) ± 29(theory)  fb.These results, along with the observed differential yields and c…

Top quarkParticle physicsPhysics MultidisciplinaryGeneral Physics and AstronomyFOS: Physical sciences7. Clean energy01 natural sciencesJets in large-Q2 scatteringSettore FIS/04 - Fisica Nucleare e SubnucleareHigh Energy Physics - ExperimentStandard ModelNONuclear physicsPhysics and Astronomy (all)High Energy Physics - Experiment (hep-ex)0103 physical sciences[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]RapiditySDG 7 - Affordable and Clean Energy010306 general physicsNuclear ExperimentPhysicslhcbMuon/dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energyScience & Technology010308 nuclear & particles physicsPhysicsSettore FIS/01 - Fisica SperimentaleParticle physicsSigmaCharge (physics)Top quarkHEP14.70.FmPseudorapidity13.87.-aPhysical SciencesW boson14.65.HaProduction (computer science)High Energy Physics::ExperimentLHCFísica de partículesExperimentsDECAYParticle Physics - Experiment
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Study of W Boson Production in Association with Beauty and Charm

2015

The associated production of a W boson with a jet originating from either a light parton or heavy-flavor quark is studied in the forward region using proton-proton collisions. The analysis uses data corresponding to integrated luminosities of 1.0 and 2.0  fb[superscript -1] collected with the LHCb detector at center-of-mass energies of 7 and 8 TeV, respectively. The W bosons are reconstructed using the W → μν decay and muons with a transverse momentum, p[subscript T], larger than 20 GeV in the pseudorapidity range 2.0 20  GeV and 2.2 20  GeV. The fraction of W + jet events that originate from beauty and charm quarks is measured, along with the charge asymmetries of the W + b and W + c produ…

PartonATLAS DETECTOR01 natural sciencesPRODUCTION CROSS-SECTIONSHigh Energy Physics - ExperimentPhysics Particles & FieldsSettore FIS/04 - Fisica Nucleare e SubnucleareHigh Energy Physics - Experiment (hep-ex)[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]Charm (quantum number)Nuclear ExperimentBosonPhysicsPhysicsParticle physics14.70.FmPseudorapidityPhysical Sciences13.87.-aLHCParticle Physics - ExperimentQuarkNuclear and High Energy PhysicsParticle physicsCOLLISIONSAstrophysics::High Energy Astrophysical PhenomenaFOS: Physical sciencesLHCb - Abteilung HofmannHadronsAstronomy & AstrophysicsCharm quarkStandard ModelNOJets in large-Q2 scatteringNuclear physicsRATIO0103 physical sciencesSDG 7 - Affordable and Clean Energy010306 general physicsLarge Hadron Collider (France and Switzerland)MuonScience & Technology/dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energyROOT-S=7 TEV010308 nuclear & particles physicsHigh Energy Physics::PhenomenologyGran Col·lisionador d'HadronsHEPLHCbJETSW bosonHigh Energy Physics::ExperimentFísica de partículesExperimentsDECAY
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Measurement of the chi(b) (3 P) mass and of the relative rate of chi(b1) (1 P) and chi(b2) (1 P) production

2014

The production of $\chi_b$ mesons in proton-proton collisions is studied using a data sample collected by the LHCb detector, at centre-of-mass energies of $\sqrt{s}=7$ and $8$ TeV and corresponding to an integrated luminosity of 3.0 fb$^{-1}$. The $\chi_b$ mesons are identified through their decays to $\Upsilon(1S)\gamma$ and $\Upsilon(2S)\gamma$ using photons that converted to $e^+e^-$ pairs in the detector. The $\chi_b(3P)$ meson mass, and the relative prompt production rate of $\chi_{b1}(1P)$ and $\chi_{b2}(1P)$ mesons as a function of the $\Upsilon(1S)$ transverse momentum in the $\chi_b$ rapidity range 2.0< $y$<4.5, are measured. Assuming a mass splitting between the $\chi_{b1}(3P)$ an…

Quantum chromodynamics: Experimental testPhysics::Instrumentation and DetectorsNuclear TheoryQuarkoniumFlavor physics; Hadron-Hadron Scattering; Quarkonium01 natural sciencesPhysics Particles & FieldsHigh Energy Physics - ExperimentLuminositySettore FIS/04 - Fisica Nucleare e Subnucleare14.40.PqFlavor physicsDECAY; UPSILON; PSI[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]Flavor physics; Hadron-Hadron Scattering; Quarkonium; Nuclear and High Energy PhysicsPSINuclear ExperimentQCPhysicsPhysicsHadron-induced high- and super-high-energy interactions (energy > 10 GeV): Inclusive production with identified hadronParticle physicsLeptonic semileptonic and radiative decays of J/ψ Υ and other quarkoniaQuarkonium Hadron-Hadron Scattering Flavor physicsPhysical SciencesTransverse momentumFísica nuclearProduction (computer science)LHCParticle Physics - ExperimentNuclear and High Energy PhysicsParticle physicsMesonLHCb - Abteilung HofmannAstrophysics::Cosmology and Extragalactic AstrophysicsUPSILONHadronsNO13.20.Gd0103 physical sciencesRapiditySDG 7 - Affordable and Clean Energy010306 general physicsLarge Hadron Collider (France and Switzerland)/dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energyScience & TechnologyHadron-Hadron Scattering010308 nuclear & particles physicsGran Col·lisionador d'HadronsLHCb12.38.QkFlavor physicHigh Energy Physics::ExperimentHeavy quarkonia13.85.NiFísica de partículesExperimentsDECAYProduction rate
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Updated determination of D0–D¯0 mixing and CP violation parameters with D0→K+π− decays

2018

We report measurements of charm-mixing parameters based on the decay-time-dependent ratio of D0→K+π- to D0→K-π+ rates. The analysis uses a data sample of proton-proton collisions corresponding to an integrated luminosity of 5.0  fb-1 recorded by the LHCb experiment from 2011 through 2016. Assuming charge-parity (CP) symmetry, the mixing parameters are determined to be x′2=(3.9±2.7)×10-5, y′=(5.28±0.52)×10-3, and RD=(3.454±0.031)×10-3. Without this assumption, the measurement is performed separately for D0 and D¯0 mesons, yielding a direct CP-violating asymmetry AD=(-0.1±9.1)×10-3, and magnitude of the ratio of mixing parameters 1.00<|q/p|<1.35 at the 68.3% confidence level. All results incl…

PhysicsParticle physicsLuminosity (scattering theory)Meson010308 nuclear & particles physicsmedia_common.quotation_subject01 natural sciencesAsymmetrySymmetry (physics)0103 physical sciencesCP violationCharm (quantum number)010306 general physicsMixing (physics)Bar (unit)media_commonPhysical Review D
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mRNA levels for α-subunit of prolyl 4-hydroxylase and fibrillar collagens in immobilized rat skeletal muscle

1999

There is evidence that immobilization causes a decrease in total collagen synthesis in skeletal muscle within a few days. In this study, early immobilization effects on the expression of prolyl 4-hydroxylase (PH) and the main fibrillar collagens at mRNA and protein levels were investigated in rat skeletal muscle. The right hindlimb was immobilized in full plantar flexion for 1, 3, and 7 days. Steady-state mRNAs for α- and β-subunits of PH and type I and III procollagen, PH activity, and collagen content were measured in gastrocnemius and plantaris muscles. Type I and III procollagen mRNAs were also measured in soleus and tibialis anterior muscles. The mRNA level for the PH α-subunit decreas…

MaleDNA ComplementaryProtein ConformationPhysiologyProcollagen-Proline DioxygenaseDown-RegulationBiologyRats Sprague-DawleyImmobilizationchemistry.chemical_compoundHydroxyprolineBiosynthesisDownregulation and upregulationPhysiology (medical)Gene expressionmedicineAnimalsRNA MessengerMuscle Skeletalchemistry.chemical_classificationMessenger RNABase SequenceBody WeightSkeletal muscleOrgan SizeMuscle atrophyRatsMuscular Atrophymedicine.anatomical_structureBiochemistrychemistryCollagenmedicine.symptomGlycoproteinJournal of Applied Physiology
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Observation of charmonium pairs produced exclusively in $pp$ collisions

2014

A search is performed for the central exclusive production of pairs of charmonia produced in proton-proton collisions. Using data corresponding to an integrated luminosity of $3{\rm\ fb}^{-1}$ collected at centre-of-mass energies of 7 and 8 TeV, $J/\psi J/\psi$ and $J/\psi\psi(2S)$ pairs are observed, which have been produced in the absence of any other activity inside the LHCb acceptance that is sensitive to charged particles in the pseudorapidity ranges $(-3.5,-1.5)$ and $(1.5,5.0)$. Searches are also performed for pairs of P-wave charmonia and limits are set on their production. The cross-sections for these processes, where the dimeson system has a rapidity between 2.0 and 4.5, are measu…

Nuclear and High Energy PhysicsParticle physicsNuclear TheorydiffractionFOS: Physical sciencesLHCb - Abteilung HofmannHEAVY-ION COLLISIONSQCD diffraction charmoniaNOHigh Energy Physics - ExperimentLuminosityHigh Energy Physics - Experiment (hep-ex)[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]Quantum chromodynamiccharmonia; diffraction; QCDcharmonia; diffraction; QCD; Nuclear and High Energy PhysicsRapiditySDG 7 - Affordable and Clean EnergyNuclear ExperimentQCPhysics/dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energyhep-ex12.38.-tParticle physicsHadron-induced high- and super-high-energy interactions (energy > 10 GeV): Inclusive production with identified hadronHEAVY-ION COLLISIONS; 450 GEV/C; DIFFRACTION; LHCQCDCromodinàmica quànticaLHCbDifracció450 GEV/CPseudorapidityPhysics::Accelerator PhysicscharmoniaFísica nuclearHigh Energy Physics::ExperimentProduction (computer science)LHCHEAVYFísica de partículesExperiments13.85.NiDiffractionQuantum chromodynamicsParticle Physics - ExperimentJournal of Physics G: Nuclear and Particle Physics
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Major results from the first plasma campaign of the Wendelstein 7-X stellarator

2017

After completing the main construction phase of Wendelstein 7-X (W7-X) and successfully commissioning the device, first plasma operation started at the end of 2015. Integral commissioning of plasma start-up and operation using electron cyclotron resonance heating (ECRH) and an extensive set of plasma diagnostics have been completed, allowing initial physics studies during the first operational campaign. Both in helium and hydrogen, plasma breakdown was easily achieved. Gaining experience with plasma vessel conditioning, discharge lengths could be extended gradually. Eventually, discharges lasted up to 6 s, reaching an injected energy of 4 MJ, which is twice the limit originally agreed for t…

Magnetic confinementNuclear and High Energy PhysicsTechnology and EngineeringPlasma heatingCyclotron resonanceCONFINEMENT01 natural sciencesElectron cyclotron resonance010305 fluids & plasmaslaw.inventionPHYSICSNuclear physicsstellaratorcurrent drive; magnetic confinement; plasma heating; stellarator; Nuclear and High Energy Physics; Condensed Matter Physicslaw0103 physical sciencesddc:530010306 general physicstellaratorStellaratorPhysicsmagnetic confinementMagnetic confinement fusionplasma heatingcurrent drive;magnetic confinement;plasma heating;stellaratorPlasma530 PhysikCondensed Matter PhysicsTRANSPORTCurrent drivecurrent driveElectron temperaturePlasma diagnosticsAtomic physicsWendelstein 7-X[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]StellaratorNuclear Fusion
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Measurement of CP asymmetry in D 0 → K - K + and D 0 → π - πdecays

2014

Time-integrated $CP$ asymmetries in $D^0$ decays to the final states $K^- K^+$ and $\pi^- \pi^+$ are measured using proton-proton collisions corresponding to $3\mathrm{\,fb}^{-1}$ of integrated luminosity collected at centre-of-mass energies of $7\mathrm{\,Te\kern -0.1em V}$ and $8\mathrm{\,Te\kern -0.1em V}$. The $D^0$ mesons are produced in semileptonic $b$-hadron decays, where the charge of the accompanying muon is used to determine the initial flavour of the charm meson. The difference in $CP$ asymmetries between the two final states is measured to be \begin{align} \Delta A_{CP} = A_{CP}(K^-K^+)-A_{CP}(\pi^-\pi^+) = (+0.14 \pm 0.16\mathrm{\,(stat)} \pm 0.08\mathrm{\,(syst)})\% \ . \nonu…

High Energy Physics::Lattice14.40.Lb01 natural sciencesLuminositySettore FIS/04 - Fisica Nucleare e SubnucleareFlavor physicsABSORPTIONPhysics::Chemical PhysicsNuclear ExperimentQCmedia_commonCharm physicsPhysicsHadronic decays of charmed mesonCharm physics; CP violation; Flavor physics; Hadron-Hadron ScatteringParticle physicsHadron-induced high- and super-high-energy interactions (energy > 10 GeV): Inclusive production with identified hadronCharge conjugation parity time reversal and other discrete symmetrieFIS/01 - FISICA SPERIMENTALECP violation13.25.FtSCATTERING-AMPLITUDEFísica nuclearLHCParticle physicsCharm physicNuclear and High Energy PhysicsMesonmedia_common.quotation_subjectLHCb - Abteilung HofmannHadronsAsymmetryREGENERATIONTheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITYSEARCH0103 physical sciencesPiSCATTERINGSCATTERING-AMPLITUDE; REGENERATION; ABSORPTION; SEARCHSDG 7 - Affordable and Clean Energy010306 general physicsLarge Hadron Collider (France and Switzerland)/dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energyMuonHadron-Hadron Scattering010308 nuclear & particles physicsHigh Energy Physics::PhenomenologyGran Col·lisionador d'HadronsCharge (physics)LHCbFlavor physic11.30.ErHigh Energy Physics::ExperimentFísica de partículesExperiments13.85.NiCharmed mesons (|C|>0 B=0)FIS/04 - FISICA NUCLEARE E SUBNUCLEARE
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Observation of charmless baryonic decays B(s)0→pp¯h+h′−

2017

Decays of B0 and Bs0 mesons to the charmless baryonic final states pp¯h+h′-, where h and h′ each denote a kaon or a pion, are searched for using the LHCb detector. The analysis is based on a sample of proton-proton collision data collected at center-of-mass energies of 7 and 8 TeV, corresponding to an integrated luminosity of 3  fb-1. Four-body charmless baryonic Bs0 decays are observed for the first time. The decays Bs0→pp¯K+K-, Bs0→pp¯K±π∓, B0→pp¯K±π∓ and B0→pp¯π+π- are observed with a significance greater than 5 standard deviations; evidence at 4.1 standard deviations is found for the B0→pp¯K+K- decay and an upper limit is set on the branching fraction for Bs0→pp¯π+π-. Branching fraction…

Nuclear physicsBaryonPhysicsPionMeson010308 nuclear & particles physicsBranching fraction0103 physical sciences010306 general physics01 natural sciencesPhysical Review D
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Measurement of CP asymmetry in Bs0 → Ds ∓K± decays

2014

Journal of high energy physics 2018(3), 59 (2018). doi:10.1007/JHEP03(2018)059

B physicCKM angle gamma01 natural sciencesB physicsLuminosityFlavor physicsHadron-Hadron scattering (experiments)TOOLLHCb - Abteilung HintonQCmedia_commonPhysicsParticle physicsCharge conjugation parity time reversal and other discrete symmetrie12.15.HhB physics; CKM angle gamma; CP violation; Flavor physics; Hadron-Hadron ScatteringJustice and Strong InstitutionsCP violationB physics; CKM angle gamma; CP violation; Flavor physics; Hadron-Hadron Scattering; Nuclear and High Energy PhysicsFísica nuclearLHCAstrophysics::Earth and Planetary AstrophysicsParticle physicsNuclear and High Energy PhysicsVIOLATIONSDG 16 - PeaceVIOLATION; GAMMA; TOOLAstrophysics::High Energy Astrophysical Phenomenamedia_common.quotation_subject14.40.NdLHCb - Abteilung HofmannAstrophysics::Cosmology and Extragalactic AstrophysicsHadrons530Determination of Cabibbo-Kobayashi & Maskawa (CKM) matrix elementAsymmetryNOHadronic decays of bottom mesonTheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY0103 physical scienceslcsh:Nuclear and particle physics. Atomic energy. Radioactivityddc:530010306 general physicsLarge Hadron Collider (France and Switzerland)Astrophysics::Galaxy AstrophysicsHadron-Hadron Scattering010308 nuclear & particles physicsSDG 16 - Peace Justice and Strong InstitutionsGran Col·lisionador d'HadronsGAMMA/dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutionsHEPLHCbFlavor physic13.25.HwB physics; CKM angle gamma; CP violation; Flavor physics; Hadron-Hadron scattering (experiments)lcsh:QC770-798Bottom mesons (|B|>0)11.30.ErHigh Energy Physics::ExperimentB physics CKM angle gamma CP violation Flavor physics Hadron-Hadron ScatteringFísica de partículesExperiments
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Search for Structure in theBs0π±Invariant Mass Spectrum

2016

The $B_s^0\pi^\pm$ invariant mass distribution is investigated in order to search for possible exotic meson states. The analysis is based on a data sample recorded with the LHCb detector corresponding to $3$ fb$^{-1}$ of $pp$ collision data at $\sqrt{s} = 7$ and $8$ TeV. No significant excess is found, and upper limits are set on the production rate of the claimed $X(5568)$ state. Upper limits are also set as a function of the mass and width of a possible exotic meson decaying to the $B_s^0\pi^\pm$ final state.

PhysicsParticle physicsLarge Hadron Collider010308 nuclear & particles physicsHigh Energy Physics::PhenomenologySpectrum (functional analysis)General Physics and AstronomyOrder (ring theory)Function (mathematics)State (functional analysis)01 natural sciencesNuclear physicsDistribution (mathematics)0103 physical sciencesHigh Energy Physics::ExperimentInvariant massExotic meson010306 general physicsPhysical Review Letters
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Observation of $Z$ production in proton-lead collisions at LHCb

2014

The first observation of $Z$ boson production in proton-lead collisions at a centre-of-mass energy per proton-nucleon pair of $\sqrt{s_{NN}}=5~\text{TeV}$ is presented. The data sample corresponds to an integrated luminosity of $1.6~\text{nb}^{-1}$ collected with the LHCb detector. The $Z$ candidates are reconstructed from pairs of oppositely charged muons with pseudorapidities between 2.0 and 4.5 and transverse momenta above $20~\text{GeV}/c$. The invariant dimuon mass is restricted to the range $60-120~\text{GeV}/c^2$. The $Z$ production cross-section is measured to be \begin{eqnarray*} ��_{Z\to��^+��^-}(\text{fwd})&amp;=&amp;13.5^{+5.4}_{-4.0}\text{(stat.)}\pm1.2\text{(syst.)}~\text{nb} …

14.70.Hp - Z bosonProtonNuclear Theory01 natural sciencesPhysics Particles & FieldsHigh Energy Physics - ExperimentSettore FIS/04 - Fisica Nucleare e SubnucleareLuminosityHigh Energy Physics - Experiment (hep-ex)Heavy-ion collision[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]Electroweak interaction; Forward physics; Heavy Ions; Heavy-ion collision; Particle and resonance productionElectroweak interactionHeavy IonsHeavy IonNuclear ExperimentQCBosonPhysics25.75.Dw - Relativistic heavy-ion collisions: Particle and resonance production; 14.70.Hp - Z bosons; 13.38.Dg - Decays of Z bosons; 12.15.-y - Electroweak interactionsPhysicsHIGH ENERGIES12.15.-y - Electroweak interactionsParticle physicsComputer Science::Computation and Language (Computational Linguistics and Natural Language and Speech Processing)13.38.Dg - Decays of Z bosons25.75.Dw - Relativistic heavy-ion collisions: Particle and resonance productionPhysical SciencesPARTON DISTRIBUTIONS; BOSON PRODUCTION; HIGH ENERGIES; NUCLEAR PDFS; DEUTERIUM; DECAYFísica nuclearProduction (computer science)14.70.Hp - Z bosonsParticle Physics - ExperimentNuclear and High Energy PhysicsParticle physicsNUCLEAR PDFS530 PhysicsDEUTERIUMFOS: Physical sciencesPhysics InstituteLHCb - Abteilung HofmannHadronsParticle and resonance production0103 physical sciencesElectroweak interaction; Forward physics; Heavy Ions; Heavy-ion collision; Particle and resonance production; Nuclear and High Energy PhysicsSDG 7 - Affordable and Clean Energy010306 general physicsForward physicLarge Hadron Collider (France and Switzerland)BOSON PRODUCTION/dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energyScience & TechnologyMuon010308 nuclear & particles physicshep-exComputer Science::Information RetrievalGran Col·lisionador d'Hadrons13.38.Dg - Decays of Z bosonPARTON DISTRIBUTIONSForward physicsHigh Energy Physics::ExperimentFísica de partículesExperimentsDECAYEnergy (signal processing)JHEP
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Evidence for Exotic Hadron Contributions toΛb0→J/ψpπ−Decays

2016

A full amplitude analysis of $\Lambda_b^0 \to J/\psi p \pi^-$ decays is performed with a data sample acquired with the LHCb detector from 7 and 8 TeV $pp$ collisions, corresponding to an integrated luminosity of 3 fb$^{-1}$. A significantly better description of the data is achieved when, in addition to the previously observed nucleon excitations $N\to p\pi^-$, either the $P_c(4380)^+$ and $P_c(4450)^+\to J/\psi p$ states, previously observed in $\Lambda_b^0 \to J/\psi p K^-$ decays, or the $Z_c(4200)^-\to J/\psi \pi^-$ state, previously reported in $B^0 \to J/\psi K^+ \pi^-$ decays, or all three, are included in the amplitude models. The data support a model containing all three exotic sta…

PhysicsParticle physics010308 nuclear & particles physicsPartial wave analysisQuark modelGeneral Physics and AstronomyExotic hadronLambda01 natural sciencesLuminosityNuclear physicsAmplitude0103 physical sciencesHigh Energy Physics::ExperimentProduction (computer science)010306 general physicsNucleonPhysical Review Letters
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Collagens in the injured porcine intervertebral disc

1994

Spinal pain often is thought to be due to degeneration and mechanical failure of the intervertebral disc. Since the mechanical strength of the tissue depends on collagen fibers, the present study was designed to investigate the reactions in collagen metabolism after an experimentally induced disc injury. Five domestic pigs underwent an incision in the anterior part of the annulus fibrosus of disc L4-L5 through a retroperitoneal approach. The animals were killed 3 months postoperatively, and the injured discs and intact discs (controls) from different animals were removed for chemical analysis. Slices were cut from seven different parts across the disc. The concentration of total collagen (h…

Annulus (mycology)030222 orthopedicsPathologymedicine.medical_specialtyGranulation tissueIntervertebral discDegeneration (medical)Anatomy03 medical and health sciencesHydroxyprolinechemistry.chemical_compoundIntervertebral disk0302 clinical medicinemedicine.anatomical_structurechemistryCollagen metabolismmedicineOrthopedics and Sports MedicineNucleus030217 neurology & neurosurgeryJournal of Orthopaedic Research
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Differential branching fractions and isospin asymmetries of B -> K ((*)) μ(+) μ(-) decays

2014

The isospin asymmetries of $B \to K\mu^+\mu^-$ and $B \to K^{*}\mu^+\mu^-$ decays and the partial branching fractions of the $B^0 \to K^0\mu^+\mu^-$, $B^+ \to K^+\mu^+\mu^-$ and $B^+ \to K^{*+}\mu^+\mu^-$ decays are measured as functions of the dimuon mass squared, $q^2$. The data used correspond to an integrated luminosity of 3$~$fb$^{-1}$ from proton-proton collisions collected with the LHCb detector at centre-of-mass energies of 7$\,$TeV and 8$\,$TeV in 2011 and 2012, respectively. The isospin asymmetries are both consistent with the Standard Model expectations. The three measured branching fractions, while individually consistent, all favour lower values than their respective Standard M…

B physic01 natural sciences7. Clean energyB physicsLuminosity/dk/atira/pure/sustainabledevelopmentgoals/clean_water_and_sanitationHigh Energy Physics - ExperimentSettore FIS/04 - Fisica Nucleare e SubnuclearePhysics Particles & Fields[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]11.30.HvNuclear ExperimentQCPhysics02 Physical SciencesB physics; Branching fraction; Flavour Changing Neutral Currents; Hadron-Hadron Scattering; Rare decayPhysicsParticle physicsNuclear & Particles PhysicsFIS/01 - FISICA SPERIMENTALEIsospinPhysical SciencesBranching fractionFísica nuclearLHCSDG 6 - Clean Water and SanitationParticle Physics - ExperimentParticle physicsNuclear and High Energy Physics14.40.NdFlavour Changing Neutral CurrentsLHCb - Abteilung HofmannHadronsBranching (polymer chemistry)Standard Model0103 physical sciencesLeptonic semileptonic and radiative decays of bottom meson010306 general physicsFlavor symmetrieLarge Hadron Collider (France and Switzerland)01 Mathematical SciencesScience & TechnologyFlavour Changing Neutral CurrentHadron-Hadron Scattering010308 nuclear & particles physicshep-exGran Col·lisionador d'HadronsLHCbRare decay13.20.HeBottom mesons (|B|>0)High Energy Physics::ExperimentFísica de partículesExperimentsRare decay; Branching fraction; B physics; Flavour Changing Neutral Currents; Hadron-Hadron ScatteringFIS/04 - FISICA NUCLEARE E SUBNUCLEARE
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Pre- and Post-translational Regulation of Lysyl Oxidase by Transforming Growth Factor-β1 in Osteoblastic MC3T3-E1 Cells

1995

The final enzymatic step required for collagen cross-linking is the extracellular oxidative deamination of peptidyl-lysine and -hydroxylysine residues by lysyl oxidase. A cross-linked collagenous extracellular matrix is required for bone formation. The goals of this study were to compare the transforming growth factor (TGF)-beta 1 regulation of lysyl oxidase enzyme activity and steady state mRNA levels to changes in COL1A1 mRNA levels in MC3T3-E1 osteoblastic cells. TGF-beta 1 increased steady state lysyl oxidase and COL1A1 mRNA levels in a dose- and time-dependent manner. The increase in lysyl oxidase mRNA levels was transient, peaking at 12 h and 8.8 times controls in cells treated with 4…

Recombinant Fusion ProteinsLysyl oxidasemacromolecular substancesBiochemistryGene Expression Regulation EnzymologicProtein-Lysine 6-OxidaseExtracellular matrixMicechemistry.chemical_compoundTransforming Growth Factor betaEndopeptidasesTranslational regulationExtracellularAnimalsHumansRNA Messengerskin and connective tissue diseasesMolecular BiologyOsteoblastsintegumentary systembiologyOxidative deamination3T3 CellsCell BiologyMolecular biologyRecombinant ProteinsEnzyme assayKineticsHydroxylysinechemistrybiology.proteinElectrophoresis Polyacrylamide GelCollagenProtein Processing Post-TranslationalTransforming growth factorJournal of Biological Chemistry
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Studies of the resonance structure inD0→KS0K±π∓decays

2016

Amplitude models are constructed to describe the resonance structure of D0→ K-π+π+π- and D0→ K+π-π-π+ decays using pp collision data collected at centre-of-mass energies of 7 and 8 TeV with the LHCb experiment, corresponding to an integrated luminosity of 3.0 fb- 1. The largest contributions to both decay amplitudes are found to come from axial resonances, with decay modes D0→ a1(1260) +K- and D0→ K1(1270 / 1400) +π- being prominent in D0→ K-π+π+π- and D0→ K+π-π-π+, respectively. Precise measurements of the lineshape parameters and couplings of the a1(1260) +, K1(1270) - and K(1460) - resonances are made, and a quasi model-independent study of the K(1460) - resonance is performed. The coher…

PhysicsLarge Hadron Collider010308 nuclear & particles physicsResonance01 natural sciencesLuminosityNuclear physicsAmplitudePhase space0103 physical sciencesCoherence (signal processing)CP violationCharm (quantum number)Atomic physics010306 general physicsPhysical Review D
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Overview of first Wendelstein 7-X high-performance operation

2019

Abstract The optimized superconducting stellarator device Wendelstein 7-X (with major radius , minor radius , and plasma volume) restarted operation after the assembly of a graphite heat shield and 10 inertially cooled island divertor modules. This paper reports on the results from the first high-performance plasma operation. Glow discharge conditioning and ECRH conditioning discharges in helium turned out to be important for density and edge radiation control. Plasma densities of with central electron temperatures were routinely achieved with hydrogen gas fueling, frequently terminated by a radiative collapse. In a first stage, plasma densities up to were reached with hydrogen pellet injec…

TechnologyCONFINEMENT01 natural sciencesimpurities010305 fluids & plasmaslaw.inventionECR heatingDivertorDENSITY LIMITlawData_FILESGeneralLiterature_REFERENCE(e.g.dictionariesencyclopediasglossaries)004 Datenverarbeitung; InformatikPhysicsGlow dischargeDivertorCondensed Matter PhysicsContent (measure theory)ComputingMethodologies_DOCUMENTANDTEXTPROCESSINGElectron temperatureAtomic physicsddc:620StellaratorImpuritiesNuclear and High Energy PhysicsTechnology and Engineeringplasma performancechemistry.chemical_elementAtmospheric-pressure plasmaPHYSICSstellaratorPhysics::Plasma PhysicsNBI heating0103 physical sciencesdivertor010306 general physicsHeliumStellaratorPlasma performanceturbulenceFísicaW7-XTurbulenceTheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGESchemistryddc:004ddc:600Energy (signal processing)SYSTEMNuclear Fusion
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Search for weakly decaying b -flavored pentaquarks

2018

Investigations of the existence of pentaquark states containing a single $b$ (anti)quark decaying weakly into four specific final states J/$\psi K^+\pi^- p$, J/$\psi K^- \pi^- p$, J/$\psi K^- \pi^+ p$, and $J/\psi \phi (1020) p$ are reported. The data sample corresponds to an integrated luminosity of 3.0/fb in 7 and 8 TeV pp collisions acquired with the LHCb detector. Signals are not observed and upper limits are set on the product of the production cross section times branching fraction with respect to that of the $\Lambda_b$.

baryon: exoticPhysics and Astronomy (miscellaneous)7000 GeV-cms8000 GeV-cms01 natural sciencesPhysics Particles & FieldsSettore FIS/04 - Fisica Nucleare e SubnucleareHigh Energy Physics - ExperimentLuminosityHigh Energy Physics - Experiment (hep-ex)Hadron-Hadron scattering (experiments)scattering [p p][PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]exotic [baryon]LHCb - Abteilung HintonpentaquarkPhysics8000 GeV-cmsPhysicsParticle physicsPentaquark3. Good healthchannel cross section: branching ratio: upper limitExotic baryonpentaquark --> J/psi(3100) K- pi+ pBranching fraction Hadron-Hadron scattering (experiments) QCDpentaquark --> J/psi(3100) K- pi- pCERN LHC Coll7000 GeV-cmsPhysical Sciencespentaquark --> J/psi(3100) Phi(1020) pBranching fractionLHCcolliding beams [p p]Particle Physics - ExperimentQuarkParticle physicsp p: scatteringFOS: Physical sciencesAstronomy & AstrophysicsHadronsNOmultiquark[ PHYS.HEXP ] Physics [physics]/High Energy Physics - Experiment [hep-ex]0103 physical sciencesddc:530010306 general physicsLarge Hadron Collider (France and Switzerland)Science & Technologybranching ratio: upper limit [channel cross section]hep-ex010308 nuclear & particles physicsBranching fractionpentaquark --> J/psi(3100) K+ pi- pParticles and FieldGran Col·lisionador d'HadronsBottom quarkQCDLHC-BHEPLHCbHigh Energy Physics::ExperimentFísica de partículesExperimentsp p: colliding beamsexperimental resultsPhysical Review D
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Determination of γ and−2βsfrom charmless two-body decays of beauty mesons

2015

Using the latest LHCb measurements of time-dependent CP violation in the B-s(0) -> K+K- decay, a U-spin relation between the decay amplitudes of B-s(0) -> K+K- and B-0 -> p(+)p(-) decay processes allows constraints to be placed on the angle gamma of the unitarity triangle and on the B-s(0) mixing phase -2 beta(s). Results from an extended approach, which uses additional inputs on B-0 -> pi(0)pi(0) and B+ -> pi(+)pi(0) decays from other experiments and exploits isospin symmetry, are also presented. The dependence of the results on the maximum allowed amount of U-spin breaking is studied. At 68% probability, the value gamma =( 63.5(-6.7)(+7.2))degrees modulo 180 degrees is determined. In an a…

PhysicsNuclear physicsNuclear and High Energy PhysicsParticle physicsAmplitudeMesonUnitarityIsospinPiValue (computer science)CP violationBeta (velocity)Physics Letters B
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Right ventricular collagen type III and IV gene expression increases during early phases of endurance training in hypobaric hypoxic condition

1997

The objective of this study was to examine the effects of prolonged exposure to hypobaric hypoxic condition, physical training and their combination on collagen type I, III and IV gene expression in the ventricles and atria of rat heart. Male rats were assigned to four groups: normobaric sedentary (NS) and trained (NT), and hypobaric sedentary (HS) and trained (HT). Exposure to and treadmill running training in hypobaric condition were carried out in a hypobaric chamber (770–740 mbar, 2250–2550 m). Experimental periods were 10, 21 and 56 days; the groups of 91 days served as recovery groups from experimental settings of 56 days. Exposure to hypobaric condition as such and in combination wit…

MaleAtmosphere Exposure Chambersmedicine.medical_specialtyPhysiologyHeart VentriclesProcollagen-Proline DioxygenaseGene ExpressionCardiomegalyBiologyLeft ventricular hypertrophyCollagen Type IIIEndurance trainingRight ventricular hypertrophyPhysical Conditioning AnimalPhysiology (medical)Internal medicineGene expressionmedicineAnimalsHeart AtriaRNA MessengerRats WistarHypoxiaCardiac muscleBlotting Northernmedicine.diseaseRatsHydroxyprolineAtmospheric PressureEndocrinologymedicine.anatomical_structureMrna levelHypobaric chamberPhysical EnduranceCollagenCardiology and Cardiovascular MedicineBasic Research in Cardiology
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Measurement of the branching fraction of the decay Bs0→KS0KS0

2020

A measurement of the branching fraction of the decay Bs0→KS0KS0 is performed using proton-proton collision data corresponding to an integrated luminosity of 5 fb-1 collected by the LHCb experiment between 2011 and 2016. The branching fraction is determined to be B(Bs0→KS0KS0)=[8.3±1.6(stat)±0.9(syst)±0.8(norm)±0.3(fs/fd)]×10-6, where the first uncertainty is statistical, the second is systematic, and the third and fourth are due to uncertainties on the branching fraction of the normalization mode B0→φKS0 and the ratio of hadronization fractions fs/fd. This is the most precise measurement of this branching fraction to date. Furthermore, a measurement of the branching fraction of the decay B0…

PhysicsNuclear physicsNormalization (statistics)010308 nuclear & particles physicsBranching fraction0103 physical sciences010306 general physics01 natural sciencesHadronizationPhysical Review D
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Skeletal Muscle Collagen Type 1 mRNA, Prolyl-4-Hydroxylase and Hydroxyproline after Prolonged Physical Training in Hypobaric Hypoxia

1994

medicine.medical_specialtyMessenger RNAHydroxyprolinechemistry.chemical_compoundEndocrinologymedicine.anatomical_structurechemistryInternal medicinemedicineSkeletal muscleHypobaric hypoxiaGeneral MedicineCollagen type 1Clinical Science
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Measurement of the c0 Baryon Lifetime

2018

We report a measurement of the lifetime of the $��_c^0$ baryon using proton-proton collision data at center-of-mass energies of 7 and 8~TeV, corresponding to an integrated luminosity of 3.0 fb$^{-1}$ collected by the LHCb experiment. The sample consists of about 1000 $��_b^-\to��_c^0��^-\bar��_�� X$ signal decays, where the $��_c^0$ baryon is detected in the $pK^-K^-��^+$ final state and $X$ represents possible additional undetected particles in the decay. The $��_c^0$ lifetime is measured to be $��_{��_c^0} = 268\pm24\pm10\pm2$ fs, where the uncertainties are statistical, systematic, and from the uncertainty in the $D^+$ lifetime, respectively. This value is nearly four times larger than, …

Particles and fieldGeneral PhysicsMesonGeneral Physics and AstronomyFOS: Physical sciences01 natural sciences7. Clean energyOmega09 EngineeringNOLuminosityHigh Energy Physics - Experiment (hep-ex)Physics and Astronomy (all)0103 physical sciencesPhysicHeavy baryonTOOLSDG 7 - Affordable and Clean EnergyLHCb - Abteilung Hinton010306 general physicsINCLUSIVE WEAK DECAYS; DISCARDING 1/N(C); RULE; TOOL01 Mathematical SciencesQuantum chromodynamicsPhysics/dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy02 Physical Sciences010308 nuclear & particles physicsQuark modelParticle physicsState (functional analysis)HEPDISCARDING 1/N(C)BaryonLHCbHadron colliderHigh Energy Physics::ExperimentINCLUSIVE WEAK DECAYSLHCAtomic physicsFísica de partículesExperimentsRULECharm physics Oscillation Flavor physics Hadron-Hadron scattering
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Measurement of CP asymmetries in the decays B0 → K*0 μ+μ- and B+ → K+ μ+μ-

2014

The direct CP asymmetries of the decays B 0 → K *0 μ + μ − and B + → K + μ + μ − are measured using pp collision data corresponding to an integrated luminosity of 3.0 fb−1 collected with the LHCb detector. The respective control modes B 0 → J/ψK *0 and B + → J/ψK + are used to account for detection and production asymmetries. The measurements are made in several intervals of μ + μ − invariant mass squared, with the ϕ(1020) and charmonium resonance regions excluded. Under the hypothesis of zero CP asymmetry in the control modes, the average values of the asymmetries are ACP(B0→K∗0μ+μ−)=−0.035±0.024±0.003,ACP(B+→K+μ+μ−)=0.012±0.017±0.001, where the first uncertainties are statistical and the …

Nuclear and High Energy PhysicsParticle physicsB physicmedia_common.quotation_subject14.40.NdFlavour Changing Neutral CurrentsLHCb - Abteilung HofmannHadrons01 natural sciencesAsymmetryB physicsNOPhysics Particles & FieldsLuminosityStandard Model0103 physical sciencesLeptonic semileptonic and radiative decays of bottom mesonInvariant mass010306 general physicsLarge Hadron Collider (France and Switzerland)QCmedia_commonPhysicsFlavour Changing Neutral CurrentScience & TechnologyHadron-Hadron Scattering010308 nuclear & particles physicsPhysicsHigh Energy Physics::PhenomenologyGran Col·lisionador d'HadronsParticle physicsResonanceCharge conjugation parity time reversal and other discrete symmetrieLHCbCP violationRare decay13.20.HePhysical SciencesBottom mesons (|B|>0)11.30.ErFísica nuclearB physics; CP violation; Flavour Changing Neutral Currents; Hadron-Hadron Scattering; Rare decayProduction (computer science)High Energy Physics::ExperimentLHCFísica de partículesExperiments
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Effects of streptozotocin-induced diabetes, physical training and their combination on collagen biosynthesis in rat skeletal muscle.

1995

The effects of streptozotocin-induced diabetes, physical training and their combination on the activities of prolyl 4-hydroxylase (PH) and galactosylhydroxylysyl glucosyl-transferase (GGT), both marker enzymes of collagen biosynthesis, and on the concentration of hydroxyproline (Hyp) were studied in vastus lateralis, rectus femoris and gastrocnemius muscles in rats. The experimental period was 12-16 weeks. Diabetes had an overall decreasing effect on specific PH activity in all muscles studied, whereas specific GGT activity remained at control level. Total PH and GGT activities decreased in all three muscles in the diabetic animals (P < 0.001). Training caused an increase in PH and GGT acti…

Blood GlucoseMalemedicine.medical_specialtyPhysiologyProcollagen-Proline DioxygenasePhysical exerciseProcollagen glucosyltransferaseDiabetes Mellitus ExperimentalRats Sprague-DawleyHydroxyprolinechemistry.chemical_compoundInternal medicineDiabetes mellitusPhysical Conditioning AnimalGlycosyltransferasemedicineAnimalsInsulinMuscle Skeletalchemistry.chemical_classificationbiologyBody WeightSkeletal musclemedicine.diseaseStreptozotocinRatsHydroxyprolineEnzymemedicine.anatomical_structureEndocrinologychemistryGlucosyltransferasesbiology.proteinCollagenmedicine.drugActa physiologica Scandinavica
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Constraints on the unitarity triangle angleγfrom Dalitz plot analysis ofB0→DK+π−decays

2016

The first study is presented of CP violation with an amplitude analysis of the Dalitz plot of B0→DK+π- decays, with D→K+π-, K+K-, and π+π-. The analysis is based on a data sample corresponding to 3.0 fb-1 of pp collisions collected with the LHCb detector. No significant CP violation effect is seen, and constraints are placed on the angle γ of the unitarity triangle formed from elements of the Cabibbo-Kobayashi-Maskawa quark mixing matrix. Hadronic parameters associated with the B0→DK∗(892)0 decay are determined for the first time. These measurements can be used to improve the sensitivity to γ of existing and future studies of the B0→DK∗(892)0 decay.

PhysicsParticle physicsFuture studiesUnitarity010308 nuclear & particles physicsCabibbo–Kobayashi–Maskawa matrixHadronDalitz plot01 natural sciencesNuclear physicsAmplitude0103 physical sciencesCP violation010306 general physicsPhysical Review D
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Acute exercise induced changes in rat skeletal muscle mRNAs and proteins regulating type IV collagen content

2001

This experiment tested the hypothesis that running-induced damage to rat skeletal muscle causes changes in synthesis and degradation of basement membrane type IV collagen and to proteins regulating its degradation. Samples from soleus muscle and red and white parts of quadriceps femoris muscle (MQF) were collected 6 h or 1, 2, 4, or 7 days after downhill running. Increased muscle β-glucuronidase activity indicated greater muscle damage in the red part of MQF than in the white part of MQF or soleus. In the red part of MQF, type IV collagen expression was upregulated at the pretranslational level and the protein concentration decreased, whereas matrix metalloproteinase-2 (MMP-2), a protein th…

medicine.medical_specialtyTime FactorsTranscription GeneticPhysiologyPhysical ExertionMatrix metalloproteinaseBiologyRunningType IV collagenPhysiology (medical)Internal medicineGene expressionmedicineAnimalsRNA MessengerRats WistarMuscle SkeletalGlucuronidaseSoleus muscleBasement membranechemistry.chemical_classificationTissue Inhibitor of Metalloproteinase-2Tissue Inhibitor of Metalloproteinase-1Skeletal muscleTissue inhibitor of metalloproteinaseRatsmedicine.anatomical_structureEndocrinologyGene Expression RegulationMatrix Metalloproteinase 9chemistryProtein BiosynthesisMuscle Fibers Fast-TwitchMatrix Metalloproteinase 2FemaleCollagenGlycoproteinAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology
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Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive err…

2020

Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and blindness in the world. Here we present a trans-ethnic meta-analysis of corneal curvature GWAS in 44,042 individuals of Caucasian and Asian with replication in 88,218 UK Biobank data. We identified 47 loci (of which 26 are novel), with population-specific signals as well as shared signals across ethnicities. Some identified variants showed precise scaling in corneal curvature and eye elongation (i.e. axial length) to maintain eyes in emmetropia (i.e. HDAC11/FBLN2 rs2630445, RBP3 rs11204213); others exhibited association with myopia with little pleiotropic effects …

0301 basic medicinegenetic structuresMedicine (miscellaneous)EmmetropiaGenome-wide association studyVARIANTSGenome-wide association studiesSensory disorders Donders Center for Medical Neuroscience [Radboudumc 12]Cornea0302 clinical medicineRisk FactorsCorneaDatabases GeneticMULTIPLEMyopiaGene Regulatory NetworksEXPRESSION PATTERNS10. No inequalitylcsh:QH301-705.5POPULATIONGeneticseducation.field_of_studymedicine.diagnostic_testHERITABILITYCorneal DiseasesAsian Continental Ancestry Group ; Axial Length Eye ; Cornea ; Corneal Topography ; Databases Genetic ; European Continental Ancestry Group ; Gene Regulatory Networks ; Genetic Loci ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Myopia ; Phenotype ; Polymorphism Single Nucleotide ; Refractometry ; Risk Assessment ; Risk FactorsCorneal topographyEYE SIZE3. Good healthAxial Length EyePhenotypemedicine.anatomical_structureGeneral Agricultural and Biological SciencesExtracellular matrix organizationKeratoconusCorneal diseasesPopulationBiologyPolymorphism Single NucleotideRisk AssessmentArticleWhite PeopleGeneral Biochemistry Genetics and Molecular BiologyOCULAR COMPONENT DIMENSIONS03 medical and health sciencesSPHERICAL EQUIVALENTAsian PeoplemedicineHumansGenetic Predisposition to DiseaseKERATOCONUS3125 Otorhinolaryngology ophthalmologyeducationCorneal Topographymedicine.diseaseCOLLAGENeye diseasesRefractometry030104 developmental biologylcsh:Biology (General)Genetic LociRE3111 Biomedicinesense organs030217 neurology & neurosurgeryGenome-Wide Association StudyCommunications Biology
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Search for CP violation using T-odd correlations in D-0 -> K+K-pi(+)pi(-) decays

2014

A search for $CP$ violation using $T$-odd correlations is performed using the four-body $D^0 \to K^+K^-\pi^+\pi^-$ decay, selected from semileptonic $B$ decays. The data sample corresponds to integrated luminosities of $1.0\,\text{fb}^{-1}$ and $2.0\,\text{fb}^{-1}$ recorded at the centre-of-mass energies of 7 TeV and 8 TeV, respectively. The $CP$-violating asymmetry $a_{CP}^{T\text{-odd}}$ is measured to be $(0.18\pm 0.29\text{(stat)}\pm 0.04\text{(syst)})\%$. Searches for $CP$ violation in different regions of phase space of the four-body decay, and as a function of the $D^0$ decay time, are also presented. No significant deviation from the $CP$ conservation hypothesis is found.

CP violation Charm physics Hadron-Hadron Scattering Flavor physics14.40.Lb01 natural sciencesSettore FIS/04 - Fisica Nucleare e SubnucleareHigh Energy Physics - ExperimentFlavor physics[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]ASTRONOMY & ASTROPHYSICSQCmedia_commonCharm physicsPhysicsHadronic decays of charmed mesonCharm physics; CP violation; Flavor physics; Hadron-Hadron ScatteringPhysicsPHYSICS PARTICLES & FIELDSParticle physicsCharge conjugation parity time reversal and other discrete symmetrieDecay timeCP violationPhysical Sciences13.25.FtCP violationFísica nuclearLHCParticle Physics - ExperimentTRIPLE-PRODUCT CORRELATIONSPACS: 13.25.Ft 11.30.ErCharm physicNuclear and High Energy PhysicsParticle physicsmedia_common.quotation_subjectLHCb - Abteilung HofmannHadronsAsymmetryNONuclear physicsTheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY0103 physical sciencesPiSDG 7 - Affordable and Clean Energy010306 general physicsLarge Hadron Collider (France and Switzerland)Science & Technology/dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energyHadron-Hadron Scatteringhep-ex010308 nuclear & particles physicsGran Col·lisionador d'HadronsCharm physics; CP violation; Flavor physics; Hadron-Hadron Scattering; Nuclear and High Energy PhysicsBABAR detectorHEPANGULAR-CORRELATIONSLHCbFlavor physicPhase spaceBaBar11.30.ErFísica de partículesExperimentsCharmed mesons (|C|>0 B=0)
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First study of the CP-violating phase and decay-width difference in Bs0→ψ(2S)ϕ decays

2016

A time-dependent angular analysis of Bs0→ψ(2S)ϕ decays is performed using data recorded by the LHCb experiment. The data set corresponds to an integrated luminosity of 3.0fb−1 collected during Run 1 of the LHC. The CP-violating phase and decay-width difference of the Bs0 system are measured to be ϕs=0.23−0.28+0.29±0.02rad and ΔΓs=0.066−0.044+0.041±0.007ps−1, respectively, where the first uncertainty is statistical and the second systematic. This is the first time that ϕs and ΔΓs have been measured in a decay containing the ψ(2S) resonance.

PhysicsNuclear and High Energy PhysicsParticle physicsLarge Hadron ColliderLuminosity (scattering theory)010308 nuclear & particles physicsPhase (waves)Astrophysics01 natural sciencesResonance (particle physics)Angular distribution0103 physical sciencesCP violation010306 general physicsPhysics Letters B
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Physical Exercise Increases mRNA Levels of Fibrillar Collagen Types I and Iii and α-Subunit of Prolyl 4-Hydroxylase in Rat Skeletal Muscle

1994

medicine.medical_specialtyΑ subunitEndocrinologymedicine.anatomical_structureMrna levelChemistryFibrillar collagenInternal medicinemedicineSkeletal musclePhysical exerciseGeneral MedicineClinical Science
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Measurements of charm mixing and CP violation using D0→K±π∓ decays

2017

Measurements of charm mixing and CP violation parameters from the decay-time-dependent ratio of D0→K+π− to D0→K−π+ decay rates and the charge-conjugate ratio are reported. The analysis uses B¯¯¯¯→D∗+μ−X, and charge-conjugate decays, where D∗+→D0π+, and D0→K∓π±. The pp collision data are recorded by the LHCb experiment at center-of-mass energies s√ = 7 and 8 TeV, corresponding to an integrated luminosity of 3 fb−1. The data are analyzed under three hypotheses: (i) mixing assuming CP symmetry, (ii) mixing assuming no direct CP violation in the Cabibbo-favored or doubly Cabibbo-suppressed decay amplitudes, and (iii) mixing allowing either direct CP violation and/or CP violation in the superpos…

PhysicsParticle physicsLuminosity (scattering theory)010308 nuclear & particles physicsHigh Energy Physics::PhenomenologyDisjoint sets01 natural sciencesNuclear physicsAmplitude0103 physical sciencesCP violationHigh Energy Physics::ExperimentCharm (quantum number)010306 general physicsMixing (physics)Eigenvalues and eigenvectorsPhysical Review D
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