0000000000101659
AUTHOR
Bc Gomes
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): study protocol for a randomized controlled trial.
Abstract Background Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with …
Measurement of matter-antimatter differences in beauty baryon decays
Differences in the behaviour of matter and antimatter have been observed in $K$ and $B$ meson decays, but not yet in any baryon decay. Such differences are associated with the non-invariance of fundamental interactions under the combined charge-conjugation and parity transformations, known as $C\!P$ violation. Using data from the LHCb experiment at the Large Hadron Collider, a search is made for $C\!P$-violating asymmetries in the decay angle distributions of $\Lambda^0_b$ baryons decaying to $p\pi^-\pi^+\pi^-$ and $p\pi^-K^+K^-$ final states. These four-body hadronic decays are a promising place to search for sources of $C\!P$ violation both within and beyond the Standard Model of particle…