0000000000104502

AUTHOR

Nathalie André

showing 3 related works from this author

Exosomes released by keratinocytes modulate melanocyte pigmentation

2015

Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids and RNAs to regulate recipient cell functions. Skin pigmentation relies on a tight dialogue between keratinocytes and melanocytes in the epidermis. Here we report that exosomes secreted by keratinocytes enhance melanin synthesis by increasing both the expression and activity of melanosomal proteins. Furthermore, we show that the function of keratinocyte-derived exosomes is phototype-dependent and is modulated by ultraviolet B. In sum, this study uncovers an important physiological function for exosomes in human pigmentation and opens new avenues in our understanding of how pigmentation is…

KeratinocytesProteomicsUltraviolet RaysGeneral Physics and AstronomyBiologyMelanocyteProteomicsExosomesReal-Time Polymerase Chain ReactionGeneral Biochemistry Genetics and Molecular BiologyArticleTandem Mass SpectrometrymedicineHumansSecretionRNA MessengerCells CulturedMelanosomeRegulation of gene expressionMelaninsMultidisciplinaryMelanosomesEpidermis (botany)PigmentationGeneral ChemistryMicrovesiclesCell biologyMicroscopy Electronmedicine.anatomical_structureGene Expression RegulationMicroscopy FluorescenceMelanocytesEpidermisIntracellularChromatography LiquidNature Communications
researchProduct

Activités archéologiques de l'École française de Rome. Chronique. Année 2008.

2009

Plan. Ill. en coul.; International audience

Zaghouan Gouv[SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistoryéquipe de recherche[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory[ SHS.ARCHEO ] Humanities and Social Sciences/Archaeology and PrehistoryField Archaeology (en)Archéologie de terrainresearch team (en)Zaghouan Gov (en)
researchProduct

Activités archéologiques de l'École française de Rome. Chronique. Année 2007.

2008

Plan. Ill. en coul.; International audience

Zaghouan Gouvéquipe de recherche[SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory[ SHS.ARCHEO ] Humanities and Social Sciences/Archaeology and PrehistoryField Archaeology (en)Archéologie de terrainresearch team (en)Zaghouan Gov (en)
researchProduct