0000000000112879

AUTHOR

S. Piacente

showing 2 related works from this author

Cycloartane Glycosides from Astragalus erinaceus

2012

WOS: 000306925400004

lcsh:Chemistrylcsh:QD241-441lcsh:QD1-999lcsh:Organic chemistryAstragalus erinaceuslcsh:BotanycycloartaneAstragaluserinaceusLeguminosaeAstragalus erinaceus; Cycloartane; Glucuronic acid; Leguminosae; Saponin;saponinglucuronic acidlcsh:QK1-989Records of Natural Products
researchProduct

A Symphytum officinale Root Extract Exerts Anti-inflammatory Properties by Affecting Two Distinct Steps of NF-κB Signaling

2019

Symphytum officinale, commonly known as comfrey, constitutes a traditional medicinal plant with a long-standing therapeutic history, and preparations thereof have been widely used for the treatment of painful muscle and joint complaints, wound and bone healing, and inflammation. Today, its topical use is based on its analgesic and anti-inflammatory effects, which have been substantiated by modern clinical trials. However, the molecular basis of its action remained elusive. Here, we show that a hydroalcoholic extract of comfrey root impairs the development of a pro-inflammatory scenario in primary human endothelial cells in a dose-dependent manner. The extract, and especially its mucilage-de…

Pharmacologylcsh:Therapeutics. Pharmacologytransactivationinflammationlcsh:RM1-950Symphytum officinalePharmacology (medical)Comfrey; Endothelial cells; Inflammation; NF-κB; Symphytum officinale; Transactivation; Transcriptiontranscriptioncomfreyendothelial cellsNF-κBOriginal ResearchFrontiers in Pharmacology
researchProduct