0000000000114694

AUTHOR

Markus Koller

showing 4 related works from this author

Synthesis of the Racemates of the b-Carboline Alkaloid Chrysotricine and its Diastereomer

2000

The racemates of the rubiacea alkaloid Chrysotricine (1) and its diastereomer are synthesized from the isomeric mixture of linalyl oxides 3 and tryptamine in six steps, followed by separation of the diastereomers.

Tryptaminechemistry.chemical_compoundchemistryAlkaloidDiastereomerOrganic chemistryGeneral ChemistryMonatshefte für Chemie/Chemical Monthly
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Synthesis of pyrrolo[3′,4′:2,3]azepino[4,5,6-cd]indole-8,10-diones

2000

3-Amino-4-(3-indolyl)pyrrolin-2,5-diones are condensed with various aldehydes and ketones to the cor responding imines. Under Pictet-Spengler conditions, the latter do not cyclize to pyrrolo-β-carbolines, but readily yield pyrrolo[3′,4′:2,3]azepino[4,5,6-cd]indole-8,10-diones.

Indole testChemistryYield (chemistry)Organic ChemistryMedicinal chemistryJournal of Heterocyclic Chemistry
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Synthesis of Pyrrolidin-2-ones and of Staurosporine Aglycon (K-252c) by Intermolecular Michael Reaction

1999

Indolo[2,3-a]pyrrolo[3,4-c]carbazoles were isolated from nature, e.g., from low plants, especially fungi, as structurally rare natural substances. Responsible for naming and also the most important representative of this type is staurosporine (1), isolated from Streptomyces staurosporeus, and its aglycon (2), also known as staurosporinone or K-252c. 3,4-Disubstituted pyrrolidin-2-ones, a group of compounds with many interesting biological properties are related to staurosporinone. The most important property is the inhibition of protein kinase C (PKC), so that this antiproliferative agent can interfere with the cell cycle. The synthetic strategy, developed by us, allows the synthesis of pyr…

StaurosporinoneStereochemistryOrganic ChemistryIntermolecular forceEnantioselective synthesisCombinatorial chemistrychemistry.chemical_compoundchemistryNitroLactammedicineMichael reactionStaurosporineProtein kinase Cmedicine.drugThe Journal of Organic Chemistry
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ChemInform Abstract: Synthesis of Pyrrolidin-2-ones and of Staurosporine Aglycon (K-252c) by Intermolecular Michael Reaction.

2010

Indolo[2,3-a]pyrrolo[3,4-c]carbazoles were isolated from nature, e.g., from low plants, especially fungi, as structurally rare natural substances. Responsible for naming and also the most important representative of this type is staurosporine (1), isolated from Streptomyces staurosporeus, and its aglycon (2), also known as staurosporinone or K-252c. 3,4-Disubstituted pyrrolidin-2-ones, a group of compounds with many interesting biological properties are related to staurosporinone. The most important property is the inhibition of protein kinase C (PKC), so that this antiproliferative agent can interfere with the cell cycle. The synthetic strategy, developed by us, allows the synthesis of pyr…

ChemistryStereochemistryIntermolecular forceEnantioselective synthesisGeneral Medicinechemistry.chemical_compoundBiological propertyNitroMichael reactionLactammedicineStaurosporineProtein kinase Cmedicine.drugChemInform
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