0000000000115159

AUTHOR

Andrea Senft

showing 3 related works from this author

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

2014

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 x 10(-8) for rs6445055), two on chromosome 9 (P = 2.80 x 10(-11) for rs2472493 near ABCA1 and P = 6.39 x 10(-11) for rs8176693…

MaleIntraocular pressuregenetic structuresGlaucomaGenome-wide association studyCohort Studies0302 clinical medicinePolymorphism (computer science)Risk FactorsPOPULATIONGeneticsAged 80 and overRISK0303 health scienceseducation.field_of_studyCOMMON VARIANTSASSOCIATIONMiddle AgedFemaleTRIALChromosomes Human Pair 3OPEN-ANGLE GLAUCOMAChromosomes Human Pair 9Glaucoma Open-AngleATP Binding Cassette Transporter 1AdultEXPRESSIONmedicine.medical_specialtyOpen angle glaucomaGenotypePopulationChromosome 9BiologyPolymorphism Single NucleotideArticleABO Blood-Group System03 medical and health sciencesYoung AdultMeta-Analysis as TopicOphthalmologyGeneticsmedicineHumansGenetic Predisposition to DiseaseeducationCENTRAL CORNEAL THICKNESSIntraocular PressureMETAANALYSIS030304 developmental biologyGenetic associationAgedChromosomes Human Pair 11Glaucomamedicine.diseaseeye diseasesFibronectinsREDUCTIONGenetic Loci030221 ophthalmology & optometrysense organsGenome-Wide Association StudyNature Genetics
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Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies

2012

Background— Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts. Methods and Results— Continuous ABI and PAD (ABI ≤0.9) phenotypes adjusted for age and sex were examined. Each study conducted genotyping and imputed data to the ≈2.5 million single nucleotide polymorphisms (SNPs) in HapMap. Linear and logistic regression models were used to test each SNP for association with ABI and PAD using additive genetic models. Study-specific data were combined using fi…

Malegenetic associationGenome-wide association studyAetiology screening and detection [ONCOL 5]030204 cardiovascular system & hematologyBioinformaticsCohort Studies0302 clinical medicineRisk FactorsGenotypeCARDIOVASCULAR RISK-FACTORSInternational HapMap ProjectGenetics (clinical)POPULATIONGeneticsAged 80 and overPeripheral Vascular Diseases0303 health scienceseducation.field_of_studyAge FactorsMiddle AgedPhenotypeperipheral vascular diseaseMeta-analysiscardiovascular system/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingCORONARY-ARTERY-DISEASEFemaleCardiology and Cardiovascular MedicineChromosomes Human Pair 9AdultSUSCEPTIBILITY LOCIGenotypePopulationHapMap ProjectBiologyPolymorphism Single NucleotideArticleMolecular epidemiology [NCEBP 1]03 medical and health sciencesSex FactorsSDG 3 - Good Health and Well-beingGeneticscohort studyHumansAnkle Brachial Indexcardiovascular diseasesAlleleeducationHealth aging / healthy living Cardiovascular diseases [IGMD 5]AllelesMolecular epidemiology Aetiology screening and detection [NCEBP 1]030304 developmental biologyGenetic associationAgedCyclin-Dependent Kinase Inhibitor p15ABDOMINAL AORTIC-ANEURYSMcohort study ; genetic association ; genome-wide association study ; meta-analysis ; peripheral vascular diseasegenome-wide association studyMORTALITYChromosomeGENEmeta-analysisbody regionsLogistic ModelsMYOCARDIAL-INFARCTIONATHEROSCLEROSISSEQUENCE VARIANThuman activities
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The Molecular Genetic Architecture of Self-Employment

2013

Economic variables such as income, education, and occupation are known to affect mortality and morbidity, such as cardiovascular disease, and have also been shown to be partly heritable. However, very little is known about which genes influence economic variables, although these genes may have both a direct and an indirect effect on health. We report results from the first large-scale collaboration that studies the molecular genetic architecture of an economic variable-entrepreneurship-that was operationalized using self-employment, a widely-available proxy. Our results suggest that common SNPs when considered jointly explain about half of the narrow-sense heritability of self-employment es…

MaleNetherlands Twin Register (NTR)Multifactorial InheritanceHeredityEpidemiologyEconomicsIntelligenceTwinsGenome-wide association studyCORONARY HEART-DISEASESocial and Behavioral SciencesTheoreticalMissing heritability problemModelsMISSING HERITABILITYMicroeconomicsTwins DizygoticSOCIOECONOMIC-STATUSRegistriesGenetics0303 health sciencesMultidisciplinaryStatistics05 social sciencesQRGenomicsSingle NucleotideOccupational and Industrial Health/dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth3. Good healthCARDIOVASCULAR-DISEASEGenetic EpidemiologyMeta-analysisScience & Technology - Other TopicsMedicineFemalePublic HealthBehavioral and Social Aspects of HealthResearch ArticlePersonalityEmploymentGenotypeClinical Research DesignGeneral Science & Technology515 PsychologyScienceeducationSingle-nucleotide polymorphismBiostatisticsBiologyPolymorphism Single NucleotideMonozygotic03 medical and health sciencesGenome Analysis Tools0502 economics and businessMD MultidisciplinaryGenome-Wide Association StudiesGenetics/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_DizygoticHumansStatistical MethodsHuman heightPolymorphismGENOME-WIDE ASSOCIATIONBiology030304 developmental biologyGenetic associationEDUCATIONAL-ATTAINMENTScience & TechnologyComplex TraitsMULTIDISCIPLINARY SCIENCESComputational BiologyHuman GeneticsSDG 8 - Decent Work and Economic GrowthTwins Monozygoticta3121HeritabilityModels TheoreticalGenetic architectureCOMMON SNPS EXPLAINLARGE PROPORTIONGenetic PolymorphismRISK-FACTORSGene-Environment Interaction3111 BiomedicineMeta-AnalysesHUMAN HEIGHTPopulation GeneticsMathematics050203 business & managementGenome-Wide Association Study
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