Author: D. Van Baarle

0000000000116589

AUTHOR

D. Van Baarle

showing 2 related works from this author

γδT cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia.

2013

Human cytomegalovirus (CMV) infections and relapse of disease remain major problems after allogeneic stem cell transplantation (allo-SCT), in particular in combination with CMV-negative donors or cordblood transplantations. Recent data suggest a paradoxical association between CMV reactivation after allo-SCT and reduced leukemic relapse. Given the potential of Vδ2-negative γδT cells to recognize CMV-infected cells and tumor cells, the molecular biology of distinct γδT-cell subsets expanding during CMV reactivation after allo-SCT was investigated. Vδ2(neg) γδT-cell expansions after CMV reactivation were observed not only with conventional but also cordblood donors. Expanded γδT cells were ca…

Human cytomegalovirusCancer ResearchAdoptive cell transferT cellT-LymphocytesCytomegalovirusBiologyAntigenT-Lymphocyte SubsetsmedicineHomologous chromosomeHumansTransplantation HomologousLeukemiavirus diseasesReceptors Antigen T-Cell gamma-deltaHematologymedicine.diseaseTransplantationLeukemiamedicine.anatomical_structureOncologyImmunologyVirus ActivationStem cellStem Cell TransplantationLeukemia

researchProduct

Therapeutic Potential of Gammadelta T-Cells in Controlling CMV After Allogeneic Stem Cell Transplantation

2011

TransplantationTransplantationbusiness.industryImmunologyGammadelta T CellsMedicineHematologyStem cellbusinessBiology of Blood and Marrow Transplantation

researchProduct

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