0000000000116981

AUTHOR

Per Holm

showing 4 related works from this author

IVIVC for fenofibrate immediate release tablets using solubility and permeability as in vitro predictors for pharmacokinetics.

2010

The goal of this study was to investigate the in vitro-in vivo correlation (IVIVC) for fenofibrate immediate release (IR) tablet formulations based on MeltDose-technique. The in vitro determined drug solubility and permeability data were related to the C(max) values observed from two in vivo human studies. Solubility and permeation studies of fenofibrate were conducted in medium simulating the fasted state conditions in the upper jejunum, containing the surfactant compositions of the six formulations at different concentrations. The behavior of all surfactant compositions was characterized by surface tension, dynamic light scattering, and cryo-TEM. The obtained solubility and permeation dat…

AdultMalePharmaceutical ScienceBiological AvailabilityIn Vitro TechniquesDosage formPermeabilityIVIVCPulmonary surfactantPharmacokineticsFenofibrateMicroscopy Electron TransmissionIn vivomedicineHumansSolubilityChromatography High Pressure LiquidAgedActive ingredientFenofibrateChromatographyChemistryMiddle AgedJejunumSolubilityFemaleSpectrophotometry Ultravioletmedicine.drugTabletsJournal of pharmaceutical sciences
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Influence of polymer molecular weight on in vitro dissolution behavior and in vivo performance of celecoxib:PVP amorphous solid dispersions

2016

In this study, the influence of the molecular weight of polyvinylpyrrolidone (PVP) on the non-sink in vitro dissolution and in vivo performance of celecoxib (CCX):PVP amorphous solid dispersions were investigated. The dissolution rate of CCX from the amorphous solid dispersions increased with decreasing PVP molecular weight and crystallization inhibition was increased with increasing molecular weight of PVP, but reached a maximum for PVP K30. This suggested that the crystallization inhibition was not proportional with molecular weight of the polymer, but rather there was an optimal molecular weight where the crystallization inhibition was strongest. Consistent with the findings from the non…

MalePolymersChemistry PharmaceuticalBiological AvailabilityPharmaceutical Science02 engineering and technology030226 pharmacology & pharmacylaw.inventionRats Sprague-Dawley03 medical and health sciences0302 clinical medicineIn vivolawmedicineAnimalsOrganic chemistryCrystallizationDissolutionchemistry.chemical_classificationPolyvinylpyrrolidoneChemistrytechnology industry and agriculturePovidoneGeneral MedicinePolymer021001 nanoscience & nanotechnologyRatsAmorphous solidBioavailabilityMolecular WeightSolubilityChemical engineeringCelecoxibCrystallization0210 nano-technologyDispersion (chemistry)Biotechnologymedicine.drugEuropean Journal of Pharmaceutics and Biopharmaceutics
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Evaluation of drug-polymer solubility curves through formal statistical analysis: comparison of preparation techniques.

2014

ABSTRACT: In this study, the influence of the preparation technique (ball milling, spray drying, and film casting) of a supersaturated amorphous dispersion on the quality of solubility determinations of indomethacin in polyvinylpyrrolidone was investigated by means of statistical analysis. After annealing of the amorphous dispersions above the crystallization temperature for 2 h, the solubility curve was derived from the glass transition temperature of the demixed material using the Gordon–Taylor relationship and fitting with the Flory–Huggins model. The study showed that the predicted solubility from the ball-milled mixtures was not consistent with those from spray drying and film casting,…

Models MolecularMaterials scienceHot TemperatureChemistry PharmaceuticalDrug CompoundingIndomethacinAnalytical chemistryPharmaceutical SciencemedicinePharmaceutic AidsSolubilitySupersaturationReproducibilityPolyvinylpyrrolidoneCalorimetry Differential ScanningAnti-Inflammatory Agents Non-SteroidalPovidoneReproducibility of ResultsCastingAmorphous solidChemical engineeringSolubilitySpray dryingEmulsionsGlass transitionPowder Diffractionmedicine.drugJournal of pharmaceutical sciences
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Influence of Polymer Molecular Weight on Drug–polymer Solubility: A Comparison between Experimentally Determined Solubility in PVP and Prediction Der…

2015

ABSTRACT: In this study, the influence of polymer molecular weight on drug–polymer solubility was investigated using binary systems containing indomethacin (IMC) and polyvinylpyrrolidone (PVP) of different molecular weights. The experimental solubility in PVP, measured using a differential scanning calorimetry annealing method, was compared with the solubility calculated from the solubility of the drug in the liquid analogue N-vinylpyrrolidone (NVP). The experimental solubility of IMC in the low-molecular-weight PVP K12 was not significantly different from that in the higher molecular weight PVPs (K25, K30, and K90). The calculated solubilities derived from the solubility in NVP (0.31–0.32 …

chemistry.chemical_classificationCalorimetry Differential ScanningPolyvinylpyrrolidonePolymersIndomethacinPovidonePharmaceutical SciencePolymerFlory–Huggins solution theoryPyrrolidinonesMolecular Weightchemistry.chemical_compoundHildebrand solubility parameterMonomerDifferential scanning calorimetrySolubilitychemistryChemical engineeringSpray dryingmedicineOrganic chemistrySolubilitymedicine.drugJournal of Pharmaceutical Sciences
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