0000000000117456
AUTHOR
W. Strauss
A population-based coprological study of human fascioliasis in a hyperendemic area of the Bolivian Altiplano
The community of Chijipata Alta, at an altitude of 3850 m, near the southern coast of Lake Titicaca in the Northern Altiplano of Bolivia, was surveyed for human fascioliasis. The global prevalence (66.7 %) and intensity (eggs per gram of faeces - epg: range: 24-4440; arithmetic mean: IooI; geometric mean: 390) proved to be the highest known in the world by means of coprological techniques. These results suggest the existence of highly hyperendemic subzones among the large human fascioliasis-endemic zone of the Bolivian Northern Altiplano. Despite the decrease in prevalence and intensity from children (75.0%, 24-4440 epg) to adults (41.7%, 144-864 epg), our findings show that in an hyperende…
Wachstumsgeschwindigkeit, Angiogenese, Durchblutung und lokale Gewebsoxygenierung ras-Onkogen-induzierter Tumoren
Bosartiges Wachstum beruht auf der Aktivierung sog. Onkogene oder auf dem Verlust von Tumorsuppressor-Genen. Solche genetischen Veranderungen konnen direkt die Sensibilitat der Tumorzellen fur verschiedene Therapieformen modulieren. Weiterhin kann sich sekundar in Tumoren ein besonderes Mikromilieu auspragen, das das biologische Verhalten der Tumorzellen beeinflust. Da bislang nur sparliche Daten vorliegen, wurden mogliche Zusammenhange zwischen einer Onkogen-Aktivierung, dem Wachstumsverhalten, der Durchblutung und der Oxygenierung maligner Tumoren an Onkogen-transformierten Rattenfibroblasten untersucht.
The Northern Bolivian Altiplano: a region highly endemic for human fascioliasis.
The worldwide importance of human infection by Fasciola hepatica has been recognized in recent years. The endemic region between Lake Titicaca and the valley of La Paz, Bolivia, at 3800-4100 m altitude, presents the highest prevalences and intensities recorded. Large geographical studies involving Lymnaea truncatula snails (malacological, physico-chemical, and botanic studies of 59, 28 and 30 water bodies, respectively, inhabited by lymnaeids; environmental mean temperature studies covering a 40-year period), livestock (5491 cattle) and human coprological surveys (2723 subjects, 2521 of whom were school children) were conducted during 1991-97 to establish the boundaries and distributional c…
Vascularity, perfusion rate and local tissue oxygenation of tumors derived from ras-transformed fibroblasts.
Tumors derived from ras-transformed rat fibroblasts were investigated in order to gain insight into possible interrelationships between oncogenic transformations and therapeutically relevant parameters of the metabolic micromilieu of solid tumors in vivo. Tumors grew in nude mice after injection of in vitro-passaged cells. Growth rates, early stages of angiogenesis, perfusion and tissue oxygenation were assessed. Compared with the parental cell line, both ras transformants grew very rapidly and exhibited an early onset of angiogenesis. Perfusion rates of one ras-transformed tumor line were similar to those of the parental tumors whereas reduced flow values were detected in tumors of the oth…