0000000000117641
AUTHOR
Yadong Wang
Fatal Tumour Lysis Syndrome Induced by Brigatinib in a Lung Adenocarcinoma Patient Treated With Sequential ALK Inhibitors: A Case Report
Tumour lysis syndrome (TLS) represents a group of fatal metabolic derangements resulting from the rapid breakdown of tumour cells. TLS typically occurs soon after the administration of chemotherapy in haematologic malignancies but is rarely observed in solid tumours. Here, we report a case of brigatinib-induced TLS after treatment with sequential anaplastic lymphoma kinase (ALK) inhibitors in a patient with advanced ALK-rearranged lung adenocarcinoma. The patient was treated sequentially with crizotinib, alectinib, and ensartinib. High-throughput molecular profiling after disease progression indicated that brigatinib may overcome ALK resistance mutations, so the patient was administered bri…
Existence and dynamics of pairs of temporal cavity solitons weakly-bound through kelly sidebands in a passive optical fiber resonator
We report experimental observations of weaklybound states of temporal cavity solitons, with separations of 10 soliton widths and beyond, in a 100-m single mode fiber cavity. Bound state dynamics has been studied using the real time dispersive Fourier transform technique for roundtrip-byroundtrip measurements. Temporal oscillations in the cavity soliton background, associated with the presence of Kelly sidebands, have been identified as the binding mechanism.
Dissipative polarization domain walls as persisting topological defects
We experimentally demonstrate the existence of dissipative polarization domain walls in a normally dispersive Kerr resonator. We excite and trap them with appropriate external signals thus realizing an all-optical buffer for topological data.
Buffering optical topological data using passive Kerr resonators
We experimentally demonstrate the existence of dissipative polarization domain walls, in a normally dispersive Kerr resonator. Through deterministic manipulation of the laser driving the resonator, we achieve systematic excitation and locking of the domain walls.
Imperfect symmetry breaking
By considering a nonlinear resonator driven by an elliptically polarized beam, we study experimentally the robustness of spontaneous symmetry breaking to controlled asymmetries. In particular, we reveal that different asymmetries can balance each other.
Potential treatment strategy for the rare osimertinib resistant mutation EGFR L718Q
Epidermal growth factor receptor (EGFR) L718Q is a rare resistant mutation which independently leads to third-generation tyrosine kinase inhibitor (TKI) resistance. Although a few studies have examined its resistance mechanisms, no effective treatment strategy has yet been proposed for patients with this mutation. Here, we report an effective treatment strategy for the rare EGFR L718Q mutation for the first time. A 44-year-old Chinese male patient initially presented with the sensitizing EGFR L858R mutation, and the progression-free survival (PFS) time after initial icotinib treatment was 9 months. When the progression of the disease (PD) and the EGFR T790M mutation were identified, he did …