0000000000122911

AUTHOR

John J. Kopchick

showing 4 related works from this author

Interventions to Slow Aging in Humans: Are We Ready?

2015

The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?' was held in Erice, Italy, on October 8-13, 2013, to bring together leading experts in the biology and genetics of aging and obtain a consensus related to the discovery and development of safe interventions to slow aging and increase healthy lifespan in humans. There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age. Essential pathways have been identified, and behavioral, dietary, and pharmacologic approaches have emerged. Although many gene targets and drugs were discussed and there was not complete consens…

GerontologyAgingDisease onsetPrescription DrugsLongevityPsychological interventionReviewsBiologyAMP-Activated Protein KinasesGrowth hormoneAging; Anti-aging; Centenarians; Dietary restriction; Lifespan studies; Longevity gene; Longevity regulation; Cell Biology; AgingDietary interventionsBiological FactorsMicelongevity geneSettore BIO/13 - Biologia ApplicataAnimalsHumansSirtuinsProtein restrictionCentenarianInsulin-Like Growth Factor ILifespan studieCaloric RestrictionSettore MED/04 - Patologia GeneraleGeroscienceGene targetsRibosomal Protein S6 KinasesTOR Serine-Threonine Kinasesanti-agingdietary restrictionCell Biologydietary restriction ; lifespan studies ; longevity gene ; centenarians ; anti-aging ; longevity regulation ; aginglongevity regulation3. Good healthDietEnzyme ActivationGene Expression RegulationGrowth HormoneGenetics of agingcentenariansaging; anti-aging; centenarians; dietary restriction; lifespan studies; longevity gene; longevity regulationSignal Transductionlifespan studies
researchProduct

Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

2016

SummaryImmune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction changes in long-term hematopoietic stem cells (LT-HSCs) and niche cells that promote stress resistance, self-renewal, and lineage-balanced regeneration. Multiple cycles of fasting abated the immunosuppression and mortality caused by chemotherapy and reversed age-dependent myeloid-bias in mice, in agreement with preliminary data on the protection of lymphocytes from chemotoxicity in fasting patients. The proregenerative effects of fasting on stem cells were recapitula…

0301 basic medicinemedicine.medical_specialtyhematopoietic regenerationfastingmedicine.medical_treatmentCellBiologyMice03 medical and health sciences0302 clinical medicineImmune systemSettore BIO/13 - Biologia ApplicataInternal medicinemedicineGeneticsAnimalsRegenerationInsulin-Like Growth Factor I030304 developmental biologyImmunosuppression Therapy0303 health sciencesstem cells; fasting; nutrition; hematopoietic regenerationRegeneration (biology)Hematopoietic stem cellImmunosuppressionCell BiologyHematopoietic Stem CellsCyclic AMP-Dependent Protein Kinases3. Good healthCell biologyMice Inbred C57BLstem cellHaematopoiesisEndocrinologynutrition030104 developmental biologymedicine.anatomical_structure030220 oncology & carcinogenesisMolecular MedicineSignal transductionStem cellCell Stem Cell
researchProduct

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis

2022

The association between IGF-1 levels and mortality in humans is complex with low levels being associated with both low and high mortality. The present meta-analysis investigates this complex relationship between IGF-1 and all-cause mortality in prospective cohort studies. A systematic literature search was conducted in PubMed/MEDLINE, Scopus, and Cochrane Library up to September 2019. Published studies were eligible for the meta-analysis if they had a prospective cohort design, a hazard ratio (HR) and 95% confidence interval (CI) for two or more categories of IGF-1 and were conducted among adults. A random-effects model with a restricted maximum likelihood heterogeneity variance estimator w…

AdultCohort StudiesAgingIGF-1HumansCell BiologyProspective StudiesInsulin-Like Growth Factor Imortalityprotein intakeProportional Hazards Models
researchProduct

Effect of circulating growth hormone on muscle IGF-I protein concentration in female mice with growth hormone receptor gene disruption.

2009

Growth hormone (GH) is a potent secretague for circulating insulin-like growth factor-I (IGF-I). The purpose of this study was to examine the effect of circulating GH on muscle IGF-I protein expression using GH transgenic animal models. Three different models were used: mice that overexpress bovine GH (bGH; n=10), mice without a functional GH receptor (GHR-/-; n=10), and wildtype mice (n=10). All mice were 16-week old females and each group differed in their basic phenotypic characteristics. Immediately after euthanization the triceps surae muscle group (soleus, plantaris, and gastrocnemius muscles) was removed. IGF-I was extracted from the muscle with an acid-ethanol solution (12.5% 2N hyd…

Malemedicine.medical_specialtyEndocrinology Diabetes and MetabolismTransgenemedicine.medical_treatmentMice TransgenicGrowth hormone receptorBiologyMiceEndocrinologyTriceps surae muscleInternal medicinemedicineAnimalsInsulin-Like Growth Factor IReceptorMuscle SkeletalInsulin-like growth factor 1 receptorMice KnockoutGrowth factorRadioimmunoassayReceptors SomatotropinMice Inbred C57BLEndocrinologyGrowth HormoneCattleFemaleHormoneGrowth hormoneIGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
researchProduct