0000000000123260
AUTHOR
Rodrigo Alonso
showing 12 related works from this author
Summary Report of MINSIS Workshop in Madrid
2010
Recent developments on tau detection technologies and the construction of high intensity neutrino beams open the possibility of a high precision search for non-standard {\mu} - {\tau} flavour transition with neutrinos at short distances. The MINSIS - Main Injector Non-Standard Interaction Search- is a proposal under discussion to realize such precision measurement. This document contains the proceedings of the workshop which took place on 10-11 December 2009 in Madrid to discuss both the physics reach as well as the experimental requirements for this proposal.
$SU(2)\times U(1)$ gauge invariance and the shape of new physics in rare $B$ decays
2014
New physics effects in $B$ decays are routinely modeled through operators invariant under the strong and electromagnetic gauge symmetries. Assuming the scale for new physics is well above the electro-weak scale, we further require invariance under the full Standard-Model gauge symmetry group. Retaining up to dimension-6 operators, we unveil new constraints between different new-physics operators that are assumed to be independent in the standard phenomenological analyses. We illustrate this approach by analyzing the constraints on new physics from rare $B_{q}$ (semi-)leptonic decays.
Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collabora…
2018
PubMed: 30270054
New physics in the kinematic distributions of $\bar B\to D^{(*)}\tau^-(\to\ell^-\bar\nu_\ell\nu_\tau)\bar\nu_\tau$
2016
We investigate the experimentally-accessible kinematic distributions of the $\bar B\to D^{(*)}\tau^-(\to\ell^-\bar\nu_\ell\nu_\tau)\bar\nu_\tau$ decays. Specifically, we study the decay rates as functions of the $B\to D^{(*)}$ transferred squared momentum, the energy of the final charged lepton and the angle of its 3-momentum relative to the 3-momentum of the recoiling $D^{(*)}$. The angular distribution allows to introduce new observables, like a forward-backward asymmetry, which are complementary to the total rates. We present analytic formulas for the observable 3-fold 5-body differential decay rates, study the predictions in the Standard Model and investigate the effects in different ne…
Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)
2021
Background The European Atherosclerosis Society Familial Hypercholesterolaemia Studies Collaboration (FHSC) global registry provides a platform for the global surveillance of familial hypercholesterolaemia through harmonisation and pooling of multinational data. In this study, we aimed to characterise the adult population with heterozygous familial hypercholesterolaemia and described how it is detected and managed globally. Methods Using FHSC global registry data, we did a cross-sectional assessment of adults (aged 18 years or older) with a clinical or genetic diagnosis of probable or definite heterozygous familial hypercholesterolaemia at the time they were entered into the registries. Dat…
Familial hypercholesterolaemia: A global call to arms
2015
Familial Hypercholesterolaemia (FH) is the commonest autosomal co-dominantly inherited condition affecting man. It is caused by mutation in one of three genes, encoding the low-density lipoprotein (LDL) receptor, or the gene for apolipoprotein B (which is the major protein component of the LDL particle), or in the gene coding for PCSK9 (which is involved in the degradation of the LDL-receptor during its cellular recycling). These mutations result in impaired LDL metabolism, leading to life-long elevations in LDL-cholesterol (LDL-C) and development of premature atherosclerotic cardiovascular disease (ASCVD) [1], [2] and [3]. If left untreated, the relative risk of premature coronary artery d…
Treating homozygous familial hypercholesterolemia in a real-world setting: Experiences with lomitapide
2015
Homozygous familial hypercholesterolaemia (HoFH) is a rare genetic disease characterised by markedly elevated plasma levels of low-density lipoprotein-cholesterol (LDL-C). Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor approved as an adjunct to other lipid-lowering therapies (LLTs), with or without lipoprotein apheresis (LA), for the treatment of adult HoFH. Diet with <20% calories from fat is required. Due to a varying genetic and phenotypic profile of patients with HoFH, individual patients may respond to therapy differently; therefore examining individual cases in a 'real-world' setting provides valuable information on the effective day-to-day manag…
Lepton universality violation with lepton flavor conservation in B-meson decays
2015
Anomalies in semileptonic B-meson decays present interesting patterns that might be revealing the shape of the new physics to come. Under the assumption that neutrino and charged lepton mass terms are the only sources of flavor violation and given the hierarchy between the two, we find that charged lepton universality violation without charged lepton flavor violation naturally arises. This can account for a deficit of B + → K + μμ over B + → K + ee decays with new physics coupled predominantly to muons and a new physics scale of a few TeV. A generic prediction of this scenario is a large enhacement of tauonic B decay rates that, in particular, could accommodate an excess in B → D (∗) τ ν. F…
New physics in the kinematic distributions of B¯→D(*)τ−(→ℓ−ν¯ℓντ)ν¯τ
2016
We investigate the experimentally accessible kinematic distributions of the $\overline{B}\ensuremath{\rightarrow}{D}^{(*)}{\ensuremath{\tau}}^{\ensuremath{-}}(\ensuremath{\rightarrow}{\ensuremath{\ell}}^{\ensuremath{-}}{\overline{\ensuremath{\nu}}}_{\ensuremath{\ell}}{\ensuremath{\nu}}_{\ensuremath{\tau}}){\overline{\ensuremath{\nu}}}_{\ensuremath{\tau}}$ decays. Specifically, we study the decay rates as functions of the $B\ensuremath{\rightarrow}{D}^{(*)}$ transferred squared momentum, the energy of the final charged lepton and the angle of its 3-momentum with respect to the 3-momentum of the recoiling ${D}^{(*)}$. The angular distribution allows to introduce new observables, like a forwar…
SU(2)×U(1)Gauge Invariance and the Shape of New Physics in RareBDecays
2014
New physics effects in B decays are routinely modeled through operators invariant under the strong and electromagnetic gauge symmetries. Assuming the scale for new physics is well above the electroweak scale, we further require invariance under the full standard model gauge symmetry group. Retaining up to dimension-six operators, we unveil new constraints between different new physics operators that are assumed to be independent in the standard phenomenological analyses. We illustrate this approach by analyzing the constraints on new physics from rare B(q) (semi-)leptonic decays.
Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and …
2016
WOS: 000393031600001
Lepton universality violation and lepton flavor conservation in $B$-meson decays
2015
Anomalies in (semi)leptonic $B$-meson decays present interesting patterns that might be revealing the shape of the new physics to come. In order to understand the experimental data, we explore symmetry arguments that lead to the hypothesis of minimal flavor violation. In particular, under the assumption of negligible neutrino mass effects in charged lepton processes, the presence of lepton universality violation without lepton flavor violation naturally arises. This can account for a deficit of $B^+\to K^+\mu\mu$ over $B^+\to K^+ee$ decays with new physics coupled predominantly to muons and a new physics scale of a few TeV. A prediction of this scenario is the modification of processes invo…