0000000000124024

AUTHOR

Maria Giuseppina Strillacci

showing 2 related works from this author

Preselection statistics and Random Forest classification identify population informative single nucleotide polymorphisms in cosmopolitan and autochth…

2018

Commercial single nucleotide polymorphism (SNP) arrays have been recently developed for several species and can be used to identify informative markers to differentiate breeds or populations for several downstream applications. To identify the most discriminating genetic markers among thousands of genotyped SNPs, a few statistical approaches have been proposed. In this work, we compared several methods of SNPs preselection (Delta, F st and principal component analyses (PCA)) in addition to Random Forest classifications to analyse SNP data from six dairy cattle breeds, including cosmopolitan (Holstein, Brown and Simmental) and autochthonous Italian breeds raised in two different regions and …

0301 basic medicineGenetic MarkersLinkage disequilibriumGenotypePopulationAnimal Identification SystemsSNPSingle-nucleotide polymorphismBiologyBreedingPolymorphism Single NucleotideSF1-1100Linkage Disequilibrium03 medical and health sciencesSettore AGR/17 - Zootecnica Generale E Miglioramento GeneticoSNPAnimalsBos tauruSelection GeneticeducationSelection (genetic algorithm)Geneticseducation.field_of_studyPrincipal Component AnalysisRandom ForestBos taurus; breed assignment; Random Forest; SNP; Animal Science and Zoology0402 animal and dairy science04 agricultural and veterinary sciencesPhenotypic trait040201 dairy & animal scienceBos taurusSNP genotypingAnimal culture030104 developmental biologyPhenotypeItalyGenetic markerSNP breed assignment Random Forest Bos taurusCattleAnimal Science and Zoologybreed assignmentAnimal
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Genome-wide association study between CNVs and milk production traits in Valle del Belice sheep.

2019

Copy number variation (CNV) is a major source of genomic structural variation. The aim of this study was to detect genomic CNV regions (CNVR) in Valle del Belice dairy sheep population and to identify those affecting milk production traits. The GO analysis identified possible candidate genes and pathways related to the selected traits. We identified CNVs in 416 individuals genotyped using the Illumina OvineSNP50 BeadChip array. The CNV association using a correlation-trend test model was examined with the Golden Helix SVS 8.7.0 tool. Significant CNVs were detected when their adjusted p-value was <0.01 after false discovery rate (FDR) correction. We identified 7,208 CNVs, which gave 365 C…

0301 basic medicineFalse discovery rateCandidate geneDNA Copy Number VariationsGenotypeSciencePopulationGenomic Structural VariationQuantitative Trait LociGenome-wide association studyQuantitative trait locusBiology03 medical and health sciencesSettore AGR/17 - Zootecnica Generale E Miglioramento GeneticoAnimalsLactationCopy-number variationeducationGeneGeneticseducation.field_of_studyMultidisciplinarySheepBiochemistry Genetics and Molecular Biology (all)QAnimals chromosome mapping dairying female genome-Wide association study genotype lactation sheep DNA copy number variations quantitative trait loci0402 animal and dairy scienceRChromosome Mapping04 agricultural and veterinary sciences040201 dairy & animal scienceDairying030104 developmental biologyAgricultural and Biological Sciences (all)MedicineFemaleGenome-Wide Association StudyResearch ArticlePLoS ONE
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