0000000000124198

AUTHOR

Antonio Castello

showing 4 related works from this author

The C(-260)T gene polymorphism in the promoter of the CD14 monocyte receptor gene is not associated with acute myocardial infarction.

2003

CD surface molecules mediates cell activation and signaling. In particular, CD14 on blood monocytes mediate monocyte/macrophage activation by lipopolysaccharide. Lipopolysaccharide and its receptor, CD14, have been implicated in atherogenesis. It has been recently shown that a C(-260)T polymorphism in the promoter of the CD14 receptor may be a risk factor for coronary artery disease. Recently this association has been questioned because no increased risk was found with the T allele, even in the homozygous state. In the present study we investigated a possible association between the C(-260)T polymorphism in the CD14 promoter and acute myocardial infarction. Two hundred and thrteen patients …

MaleSettore MED/09 - Medicina InternaGenotypeCD14Clinical BiochemistryLipopolysaccharide ReceptorsMyocardial InfarctionAntigens CD14Polymorphism Single NucleotideGeneral Biochemistry Genetics and Molecular BiologyCytosineGene FrequencyReference ValuesRisk FactorsGenotypemedicineHumansReference ValuePolymorphismAlleleReceptorPromoter Regions GeneticBiochemistry Genetics and Molecular Biology (all)business.industryRisk FactorMedicine (all)MonocyteSmokingCase-control studyGeneral MedicineMiddle AgedMolecular biologySurvival AnalysisGenotype frequencymedicine.anatomical_structureImmunologySettore MED/26 - NeurologiaFemaleSurvival AnalysiGene polymorphismCD14Cell activationbusinessThymineHumanClinical and experimental medicine
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Effect of physical training on exercise capacity, gas exchange and N-terminal pro-brain natriuretic peptide levels in patients with chronic heart fai…

2006

BACKGROUND: Decreased exercise capacity is the main factor restricting the daily life of patients with chronic heart failure. N-terminal pro-brain natriuretic peptide (NT pro-BNP) is strongly related to the severity of and is an independent predictor of outcome in chronic heart failure. DESIGN: The study aimed to evaluate the effect of exercise training on functional capacity and on changes in NT pro-BNP levels and to assess the effect of exercise training on quality of life. MATERIALS AND METHODS: Sixty patients (45 men/15 women, mean age 52.7 years; +/-5.3 SD), with stable heart failure (45 ischaemic/hypertensive and 15 idiopathic patients), in New York Heart Association (NYHA) functional…

Malemedicine.medical_specialtyEpidemiologymedicine.drug_classInternal medicineNatriuretic Peptide BrainNatriuretic peptideMedicineHumansIn patientExercise physiologycongestive heart failure exercise capacity gas exchange N-terminal pro-brain natriuretic peptide physical trainingExerciseHeart FailureEjection fractionbusiness.industryPulmonary Gas ExchangeExercise capacityMiddle AgedBrain natriuretic peptidemedicine.diseasePeptide FragmentsPhysical FitnessHeart failureCardiologyFemaleCardiology and Cardiovascular MedicinebusinessN-terminal pro-Brain Natriuretic PeptideEuropean journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on EpidemiologyPrevention and Cardiac Rehabilitation and Exercise Physiology
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Changes in plasma lipids and low-density lipoprotein peak particle size during and after acute myocardial infarction

2002

In summary, LDL peak particle size variations occur very early after AMI, and therefore this parameter, which may be considered a genetically determined risk factor, must be measured not before 2 to 3 months after the acute event.

AdultMalemedicine.medical_specialtyMyocardial Infarctionchemistry.chemical_compoundInternal medicineBlood plasmaPlasma lipidsmedicineHumansMyocardial infarctionLow-Density Lipoprotein Acute Myocardial InfarctionRisk factorAgedAged 80 and overbusiness.industryCholesterolCholesterol HDLCholesterol LDLMiddle Agedmedicine.diseaseLipidsCoronary heart diseaseEndocrinologychemistryLow-density lipoproteinCardiologyParticle sizeCardiology and Cardiovascular MedicinebusinessThe American Journal of Cardiology
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Cystatin C levels are decreased in acute myocardial infarction

2005

Background: Cystatin C is the most abundant protease inhibitor in the plasma. Low plasma levels have been found in patients with aortic aneurysms and they seem correlated with the extension of the aortic lesions in early aneurysms detected by ultrasonography. Methods: In this study, plasma levels of cystatin C have been investigated in patients with acute myocardial infarction (AMI), unstable angina and controls. The effect on plasma levels of the G73A polymorphism of the CST3 gene has been also evaluated. Results: Patients with acute myocardial infarction showed significantly lower levels of cystatin C compared to unstable angina and controls, but levels were nearly normal in a week after …

medicine.medical_specialtybiologyCholesterolbusiness.industryUnstable anginaAcute-phase proteinurologic and male genital diseasesmedicine.diseaseCoronary artery diseasechemistry.chemical_compoundEndocrinologyCystatin CchemistryInternal medicineBlood plasmaCardiologymedicinebiology.proteincardiovascular diseasesGene polymorphismMyocardial infarctionCardiology and Cardiovascular MedicinebusinessInternational Journal of Cardiology
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