0000000000125701

AUTHOR

Xiaolan Hu

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Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder

2010

Contains fulltext : 87688.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. As prior genome-wide association studies (GWAS) have not yielded significant results, we conducted a meta-analysis of existing studies to boost statistical power. METHOD: We used data from four projects: a) the Children's Hospital of Philadelphia (CHOP); b) phase I of the International Multicenter ADHD Genetics project (IMAGE); c) phase II of IMAGE (IMAGE II); and d) the Pfizer-funded study from the…

Malemedicine.medical_specialtyCandidate geneAdolescentMedizinSocial SciencesGenome-wide association studySingle-nucleotide polymorphismPolymorphism Single NucleotideArticleGenomic disorders and inherited multi-system disorders [IGMD 3]03 medical and health sciences0302 clinical medicinePerception and Action [DCN 1]Developmental and Educational PsychologymedicineIMPUTATIONAttention deficit hyperactivity disorderddc:61Humansddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersInternational HapMap ProjectPsychiatryChildGenetic Association Studies030304 developmental biologyGenetic associationMental Health [NCEBP 9]0303 health sciencesCOMPONENTSmedicine.disease3. Good healthPREVALENCEPsychiatry and Mental healthAttention Deficit Disorder with HyperactivityMeta-analysisChild PreschoolFemalePsychologyFunctional Neurogenomics [DCN 2]030217 neurology & neurosurgeryImputation (genetics)Clinical psychologyGenome-Wide Association Study
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