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RESEARCH PRODUCT
Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder
Xiaolan HuMichael Conlon O'donovanRichard P. EbsteinMark J. DalyMark J. DalySarah E. MedlandSarah E. MedlandPhilip AshersonBenjamin M. NealeBenjamin M. NealeRobert D. OadesEric MickEric MickTobias BanaschewskiStephan RipkeStephan RipkeAnita ThaparChristine M. FreitagNanda Lambregts-rommelseFrank A. MiddletonAribert RothenbergerStanley F. NelsonAlexandre A. TodorovEdmund J.s. Sonuga-barkeEdmund J.s. Sonuga-barkeEdmund J.s. Sonuga-barkeKlaus-peter LeschNigel WilliamsSusan L. SmalleyThuy Trang NguyenLaura NisenbaumAndreas ReifSusanne WalitzaSusanne WalitzaHaukur PalmasonLindsey KentKate LangelyHerbert RoeyersTobias J. RennerJosephine EliaJoseph A. SergeantJames J. McgoughHelmut SchäferBarbara FrankeStephen V. FaraoneAlejandro Arias VasquezJan K. BuitelaarAlysa E. DoyleAlysa E. DoyleMichael GillJasmin RomanosHans-christoph SteinhausenHans-christoph SteinhausenHans-christoph SteinhausenRichard AnneyJobst MeyerSandra K. LooAna MirandaMarcel RomanosJoseph BiedermanPeter HolmansHakon HakonarsonHakon HakonarsonFernando MulasAndreas WarnkeMichael John Owensubject
Malemedicine.medical_specialtyCandidate geneAdolescentMedizinSocial SciencesGenome-wide association studySingle-nucleotide polymorphismPolymorphism Single NucleotideArticleGenomic disorders and inherited multi-system disorders [IGMD 3]03 medical and health sciences0302 clinical medicinePerception and Action [DCN 1]Developmental and Educational PsychologymedicineIMPUTATIONAttention deficit hyperactivity disorderddc:61Humansddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersInternational HapMap ProjectPsychiatryChildGenetic Association Studies030304 developmental biologyGenetic associationMental Health [NCEBP 9]0303 health sciencesCOMPONENTSmedicine.disease3. Good healthPREVALENCEPsychiatry and Mental healthAttention Deficit Disorder with HyperactivityMeta-analysisChild PreschoolFemalePsychologyFunctional Neurogenomics [DCN 2]030217 neurology & neurosurgeryImputation (genetics)Clinical psychologyGenome-Wide Association Studydescription
Contains fulltext : 87688.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. As prior genome-wide association studies (GWAS) have not yielded significant results, we conducted a meta-analysis of existing studies to boost statistical power. METHOD: We used data from four projects: a) the Children's Hospital of Philadelphia (CHOP); b) phase I of the International Multicenter ADHD Genetics project (IMAGE); c) phase II of IMAGE (IMAGE II); and d) the Pfizer-funded study from the University of California, Los Angeles, Washington University, and Massachusetts General Hospital (PUWMa). The final sample size consisted of 2,064 trios, 896 cases, and 2,455 controls. For each study, we imputed HapMap single nucleotide polymorphisms, computed association test statistics and transformed them to z-scores, and then combined weighted z-scores in a meta-analysis. RESULTS: No genome-wide significant associations were found, although an analysis of candidate genes suggests that they may be involved in the disorder. CONCLUSIONS: Given that ADHD is a highly heritable disorder, our negative results suggest that the effects of common ADHD risk variants must, individually, be very small or that other types of variants, e.g., rare ones, account for much of the disorder's heritability. 01 september 2010
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-09-01 |