0000000000129233

AUTHOR

Volker Wahn

showing 3 related works from this author

Predictability of early atopy by cord blood-IgE and parental history.

1997

Summary Background Atopic family history and cord blood IgE have been used as predictors of atopic disease in newborns for about 20 years, but at least for cord blood IgE the sensitivity has been shown to be very low. The objective of this paper was to evaluate whether parental history and cord blood-IgE were more accurate predictors for the appropriate atopic phenotypes in the infants rather than for any atopy. Methods A total of 1314 newborn infants was recruited in six German obstetric departments in 1990 and followed-up for 2 years. Four hundred and ninty-ninc (38%) were at high risk for atopy with at least two first degree atopic family members and/or elevated cord-blood IgE concentrat…

AdultHypersensitivity ImmediateAllergyPediatricsmedicine.medical_specialtyImmunologyImmunoglobulin EAtopyCohort StudiesPregnancyRisk FactorsGermanyImmunology and AllergyMedicineHumansCumulative incidenceProspective StudiesFamily historyAsthmaFamily Healthbiologybusiness.industryInfant NewbornInfantAtopic dermatitisImmunoglobulin Emedicine.diseaseFetal BloodPhenotypeCord bloodbiology.proteinFemalebusinessClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
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Hereditary angioedema in children and adolescents - A consensus update on therapeutic strategies for German-speaking countries.

2020

Background/methods At a consensus meeting in August 2018, pediatricians and dermatologists from German-speaking countries discussed the therapeutic strategy for the treatment of pediatric patients with type I and II hereditary angioedema due to C1 inhibitor deficiency (HAE-C1-INH) for Germany, Austria, and Switzerland, taking into account the current marketing approval status. HAE-C1-INH is a rare disease that usually presents during childhood or adolescence with intermittent episodes of potentially life-threatening angioedema. Diagnosis as early as possible and an optimal management of the disease are important to avoid ineffective therapies and to properly treat swelling attacks. This art…

Adultmedicine.medical_specialtyAdolescentImmunology610610 Medicine & healthLanadelumabDiseaseC1-inhibitorGermanPlasma03 medical and health scienceschemistry.chemical_compound0302 clinical medicineIcatibantGermanymedicineHumansImmunology and Allergy030212 general & internal medicineAngioedemaChildIntensive care medicine610 Medicine & healthAngioedemabiologytreatmentbusiness.industryAngioedemas HereditaryC1-INH (C1 inhibitor)medicine.diseaselanguage.human_languagehereditary angioedemapediatric030228 respiratory systemchemistryconsensusPediatrics Perinatology and Child HealthHereditary angioedemalanguagebiology.proteinmedicine.symptombusinessComplement C1 Inhibitor Protein600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und GesundheitRare disease
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Transient suppression of atopy in early childhood is associated with high vaccination coverage.

2003

Objective. To analyze prevalences of allergic sensitization and atopic disease in relation to vaccination coverage. Methods. A German atopy risk-enhanced birth cohort of 1314 neonates who were born in 1990 in 5 German cities was studied. A total of 943 children participated in the follow-up visit at 5 years of age. Atopic symptoms and diagnoses (derived from structured interviews), total serum immunoglobulin E, and specific immunoglobulin E against 9 common allergens (CAP Radio-Allergo-Sorbent Test Fluoro-Enzyme Immunoassay) were evaluated. Children were grouped into dose percentiles according to cumulative doses of any vaccine given up to 5 years of age (<10%, 0–11 doses; 10%–50%, 1…

Pediatricsmedicine.medical_specialtyPercentileDose-Response Relationship ImmunologicImmunoglobulin EDermatitis AtopicAtopyRadioallergosorbent TestHypersensitivityMedicineHumansEarly childhoodSensitizationAsthmaVaccinesbiologybusiness.industryImmunization ProgramsVaccinationInfant NewbornInfantAtopic dermatitisImmunoglobulin Emedicine.diseaseAsthmamedicine.anatomical_structureVaccination coverageChild PreschoolPediatrics Perinatology and Child Healthbiology.proteinbusinessFollow-Up StudiesPediatrics
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