0000000000129365

AUTHOR

T. A. Luger

showing 2 related works from this author

An observational study to evaluate the long-term outcomes of treatment with etanercept in patients with plaque-type psoriasis

2015

Background There is an unmet need for long-term, real-life data on the effect of a drug-free interval between treatment cycles in patients with plaque psoriasis being treated with etanercept, which is licensed for intermittent and continuous treatment. Objective The aim of this study was to determine the average duration of the drug-free interval between etanercept treatment cycles in patients with plaque psoriasis. Methods This was a non-interventional, open-label, multicentre, prospective study in patients for whom the decision had already been made to initiate treatment with etanercept during routine practice in German centres. Clinical outcomes were documented over 36 months with study …

AdultMalemedicine.medical_specialtyPopulationDermatologyEtanerceptEtanercept030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicinePsoriasis Area and Severity IndexInternal medicinePsoriasisClinical endpointHumansPsoriasisMedicineAdverse effecteducationBody surface areaeducation.field_of_studybusiness.industryDermatology Life Quality IndexMiddle Agedmedicine.diseaseSurgeryInfectious Diseases030220 oncology & carcinogenesisFemalebusinessImmunosuppressive Agentsmedicine.drugJournal of the European Academy of Dermatology and Venereology
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Comparison of pegylated interferon α-2b plus psoralen PUVA versus standard interferon α-2a plus PUVA in patients with cutaneous T-cell lymphoma

2011

Objective  The aim of this study was to evaluate the safety and efficacy profile of pegylated interferon α-2b (PEG-IFN α-2b) in combination with photochemotherapy (PUVA) in the treatment of cutaneous T-cell lymphoma (CTCL) in comparison with standard IFN α plus PUVA. Design  Retrospective cohort study over a period of 7 years. Patients and interventions  A total of 17 consecutive CTCL patients (stage IA–IV) were retrospectively analysed for toxicity and response rates associated with PEG-IFN α-2b (1.5 μg/kg weekly) plus PUVA (n = 9) or standard IFN α-2a (9 MIU 3×/week) plus PUVA (n = 8). Main outcome measures  Differences of response rates (complete/partial remission), progression-free surv…

medicine.medical_specialtybusiness.industrymedicine.medical_treatmentCutaneous T-cell lymphomaDermatologymedicine.diseaseDermatologyGastroenterologyDiscontinuationchemistry.chemical_compoundInfectious DiseaseschemistryPegylated interferonInternal medicinePUVA therapyToxicitymedicinebusinessProspective cohort studyAdverse effectPsoralenmedicine.drugJournal of the European Academy of Dermatology and Venereology
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