0000000000129977
AUTHOR
Lilite Sadovska
showing 4 related works from this author
Autoantivielu biomarķieru identificēšana prostatas vēža diagnostikai
2014
Autoantivielām pret audzēja asociētiem antigēniem ir potenciāls tikt izmantotām kā biomarķieriem agrīnai vēža diagnostikai un prognostikai. Darba „Autoantivielu biomarķieru identificēšana prostatas vēža diagnostikai” mērķis bija atrast ar prostatas vēzi (PV) asociētu autoantivielu profilu, kas spētu atšķirt PV slimniekus no vīriešiem bez ļaundabīgām izmaiņām prostatā, kā arī prognozēt agresīvu slimības gaitu. Tika izveidots 158 antigēnu mikročips, ar kuru tika sistemātiski analizēti autoantivielu profili pacientos un veselos indivīdos; 42 antigēni uzrādīja diagnostisku vērtību un 13 – prognostisku. Izveidotais 42 biomarķieru panelis ar 57% precizitāti spēja atšķirt PV no kontroles grupām, t…
Exercise-Induced Extracellular Vesicles Delay the Progression of Prostate Cancer
2022
Increasing evidence suggests that regular physical exercise not only reduces the risk of cancer but also improves functional capacity, treatment efficacy and disease outcome in cancer patients. At least partially, these effects are mediated by the secretome of the tissues responding to exercise. The secreted molecules can be released in a carrier-free form or enclosed into extracellular vesicles (EVs). Several recent studies have shown that EVs are actively released into circulation during physical exercise. Here, we for the first time investigated the effects of exercise-induced EVs on the progression of cancer in an F344 rat model of metastatic prostate cancer. Although we did not observe…
Biodistribution, Uptake and Effects Caused by Cancer-derived Extracellular Vesicles
2015
Extracellular vesicles (EVs) have recently emerged as important mediators of intercellular communication. They are released in the extracellular space by a variety of normal and cancerous cell types and have been found in all human body fluids. Cancer-derived EVs have been shown to carry lipids, proteins, mRNAs, non-coding and structural RNAs and even extra-chromosomal DNA, which can be taken up by recipient cells and trigger diverse physiological and pathological responses. An increasing body of evidence suggests that cancer-derived EVs mediate paracrine signalling between cancer cells. This leads to the increased invasiveness, proliferation rate and chemoresistance, as well as the acquisi…
A novel 3D heterotypic spheroid model for studying extracellular vesicle-mediated tumour and immune cell communication
2017
Cancer-derived extracellular vesicles (EVs) have emerged as important mediators of tumour-host interactions, and they have been shown to exert various functional effects in immune cells. In most of the studies on human immune cells, EVs have been isolated from cancer cell culture medium or patients' body fluids and added to the immune cell cultures. In such a setting, the physiological relevance of the chosen EV concentration is unknown and the EV isolation method and the timing of EV administration may bias the results. In the current study we aimed to develop an experimental cell culture model to study EV-mediated effects in human T and B cells at conditions mimicking the tumour microenvi…