Terapia genica delle emoglobinopatie:stato dell'arte

Sea urchin sns chromatin insulator prebents silencing and positional effect variegation of oncoretroviral vectors transgene expression in murine erythroid cell line

Orzo da malto: risultati nazionali.

Guida alla scelta delle migliori varietà di triticale

Sea Urchin sns chromatin insulator prevents silencing and position effect variagation of oncoretroviral vectors transgene expression in murine cell line

Functional characterization and use in the retrovirus vectors of the sea urchin SNS chromatin insulator in erythroid cells

Annata critica per il tenore proteico del frumento duro biologico

321. Sea Urchin sns Chromatin Insulator Prevents Silencing and Positional Effect Variegation of Oncoretroviral Vectors Transgene Expression in Murine Erythroid Cell Line

Silencing and position effect are considered significant obstacles to obtain a consistent level of transgene expression in viral gene therapy. Furthermore recent studies had shown that retroviruses tend to land on active genes with the potential consequence of insertional mutagenesis. The inclusion of elements, such as chromatin insulators, capable to insulate a gene from the surrounding chromatin effects at the integration site should improve both efficacy and safety of gene therapy vectors. We have previously characterized a 265 bp insulator element, termed sns, localized at the 3’ end of the early histone H2A gene of the sea urchin Paracentrotus lividus. This sequence contains three cis-…

Varietà di orzo da zootecnia, da malto e a seme nudo.

The sea urchin chromatin insulator, sns-5 protect retrovirus vector from chromosomal position effects

Risultati varietali per il triticale

Studio funzionale di vettori lentivirali ricombinanti, contenenti l'isolatore cromatinico di riccio di mare sns5.

Quali varietà scegliere per l'orzo da zootecnia

Epidemiological trends of pediatric IBD in Italy: A 10-year analysis of the Italian society of pediatric gastroenterology, hepatology and nutrition registry

Introduction: The present study aimed at evaluating Italian epidemiological trends of pediatric inflammatory bowel diseases (IBD) over the period 2009–2018. Materials and methods: Data from 1969 patients enrolled in the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition Registry, by 49 pediatric IBD centers throughout the country, were analyzed, comparing three different time intervals (2009–2012, 2013–2015, 2016–2018). Results: The number of new IBD diagnoses ranged from 175 to 219 per year, evenly distributed over the examined period of time. From 2009 to 2018, the minimal incidence ranged from 1.59 to 2.04 /105 inhabitants aged < 18 years, with an overall slight p…