0000000000130199
AUTHOR
P. Manner
showing 2 related works from this author
A Poly-L-Lactide scaffold with continuous gradient pore size for osteochondral regeneration validated in a microphysiological tissue system bioreactor
2016
A microphysiological tissue system (MPS) bioreactor has been developed to replicate in vitro the in vivo OC physiological conditions. The MPS allows separate control of the chondral and osseous environment while permitting communication between chondrocytes and osteoblasts across the OC junction, similar to the conditions of OC tissue in vivo. We have used here our MPS system to validate the TIPS -generated pore-gradient PLLA scaffold.
A Continuous Pore Size Gradient PLLA Scaffold For Osteochondral Regeneration
2016
Osteochondral (OC) scaffold-based regenerative approaches in the joint are challenging since the scaffold must provide mechanical strength while also mimicking the local cartilage and bone microenvironments. Thermally Induced Phase Separation (TIPS) can produce scaffolds with a wide range of pore size morphologies/distributions. Here, we produced by TIPS a poly-L-lactide (PLL A) scaffold with a continuous pore size gradient along the sample thickness, from ~70μm diameter on one side to ~200 μm diameter on the opposite surface.