0000000000130559
AUTHOR
G. Cusimano
showing 10 related works from this author
Trace metals comparison between two volcanic islands (Vulcano and Lipari, Aeolian islands)
2006
Nose-to-brain delivery of insulin enhanced by radiation-engineered nanogels
2018
Recent evidences suggest thet insulin delivery to the brain can be an important pharmacological therapy for some neurodegenerative pathologies, including Alzheimer disease (AD)
Geochemistry and potential use of groundwater in the Rocca Busambra area (Sicily, Italy)
2008
In the Rocca Busambra area (mid-west Sicily, Italy), from November 1999 to July 2002, 23 water points including wells and springs were sampled and studied for their chemical and isotopic compositions. Two rain gauges were also installed at different altitudes, and rainwater was collected monthly to determine the isotopic composition. The obtained results revealed the Rocca Busambra carbonate complex as being the main recharge area on account of its high permeability value. From a chemical view point, two main groups of water can be distinguished: calcium–magnesium–bicarbonate-type and calcium–magnesium–chloride–sulphate-type waters. The first group reflects the dissolution of the carbonate …
Xyloglucan-based hydrogel film for wound dressing: Structure and biological properties relationships
2018
Crosslinked xyloglucan-poly(vinyl alcohol) based hydrogel films have been synthetized and characterized for wound healing applications. Polyvinyl alcohol (PVA) and glycerol (Gro) were added to have an optimal combination of softness, conformability and resilience. Physical hydrogel have been transformed into permanent covalent hydrogels by reaction with glutaraldehyde (GA). Chemical and physical properties of the films have been analyzed by different technique. Moreover, biocompatibility of a selected formulation was assessed in vitro by investigating different aspects, such as cell viability, oxidative stress, mitochondrial dysfunction and specific stress biomarkers. Partial adhesiveness w…
Assessment of nitrate contamination risk: The Italian experience
2009
16 páginas, 19 figuras, 10 tablas.-- El PDF es el manuscrito aceptado para su publicación.-- et al.
Characterisation of submarine groundwater discharge offshore south-eastern Sicily
2005
A complex approach in characterisation of submarine groundwater discharge (SGD) off south-eastern Sicily comprising applications of radioactive and non-radioactive tracers, direct seepage measurements, geophysical surveys and a numerical modelling is presented. SGD fluxes in the Donnalucata boat basin were estimated by direct seepage measurements to be from 4 to 12Ls(-1), which are comparable with the total SGD flux in the basin of 17Ls(-1) obtained from radon measurements. The integrated SGD flux over the Donnalucata coast estimated on the basis of Ra isotopes was around 60m(3)s(-1) per km of the coast. Spatial variations of SGD were observed in the Donnalucata boat basin, the average (222…
Exploring nose-to-brain insulin delivery as a new strategy for the treatment of Alzheimer’s disease
2019
A growing body of evidence shows that Insulin, Insulin Receptor (IR) and IR signaling are involved in brain cognitive functions and their dysfunction is implicated in Alzheimer’s disease (AD) degeneration. Thus, administration of insulin could be a strategy for AD treatment. For this aim we designed, synthesized and characterized a nanogel system (NG) to deliver insulin to the brain, as a tool for the development of a new therapy for AD. A carboxyl-functionalized poly(N-vinyl pyrrolidone) nanogel system produced by high energy ionizing radiation was chosen as substrate for the covalent attachment of insulin or fluorescent molecules, relevant for its tracing
Groundwater nitrate risk assessment using intrinsic vulnerability methods: A comparative study of environmental impact by intensive farming in the Me…
2015
Abstract Groundwater contamination by nitrate and other nutrients is a major problem throughout the world, often occurring as the result of anthropogenic activities, lack of management, and over-exploitation of groundwater resources. In the last few decades in the majority of the Italian regions, the nitrate concentrations in groundwater have dramatically increased, mainly as a consequence of the large-scale agricultural application of manure and fertilizers. This excessive use of chemicals and fertilizers increases the risk of surface and groundwater pollution from diffuse sources, which have an important impact on human health and the environment. Sicily is located in the central Mediterr…
Geochemical characterization of groundwater and submarine discharge in the south-eastern Sicily
2006
Abstract The main results of a hydrogeochemical survey carried out during 2002–2003 along the coast of the south-eastern Sicily, which aimed at geochemical characterization of both groundwater chemistry and submarine groundwater discharge (SGD) in the area are presented. A general frame of chemical processes affecting the studied groundwater and SGD point out that most samples fall within the calcite-anhydrite-dolomite field (CAD). The chemical composition of the samples within the CAD triangle is essentially controlled by calcite, dolomite and gypsum dissolution, which are the main minerals of the carbonate rocks hosting the aquifers. An additional process evidenced in this study is a mixi…