0000000000132758
AUTHOR
Hans J. Hennes
<title>Follow-up in patients with subdural haematomas using near-infrared spectroscopy (NIRS)</title>
Secondary haemorrhage is an important cause of brain injury following initial therapy of subdural haematoma (SDH). Early identification and treatment of secondary haemorrhage improves neurologic outcome. Near infrared light at a wavelength of 760 nm shows a high absorption for haemoglobin. The difference in absorbance of light ((Delta) OD) at the wavelength of 760 nm between both hemispheres is measured to detect SDH. We have prospectively studied 20 patients with the CT diagnosis of SDH using near infrared spectroscopy (NIRS). Unilateral subdural haematomas were detected by NIRS in 15 out of 16 patients. Bilateral SDH were detected in 2 out of 3 patients. The median of (Delta) OD was reduc…
Effects of Fenoldopam on Intracranial Pressure and Hemodynamic Variables at Normal and Elevated Intracranial Pressure in Anesthetized Pigs
Fenoldopam (FE), a dopamine DA1-receptor agonist, has been introduced for treatment of arterial hypertension and heart failure and for preservation of renal function. Vasodilators are generally assumed to affect all vascular beds including the cerebral circulation. We have evaluated effects of FE-induced (4 micrograms.kg-1.min-1) arterial hypotension on intracranial pressure (ICP) and intraocular pressure (IOP) under conditions of normal and increased intracranial elastance. ICP and IOP responses to hypertension were tested by infusion of angiotensin II (15 micrograms.kg-1.min-1), and the response to hypercapnia was tested by elimination and reintegration of soda lime canisters in the breat…
Prehospital diagnosis in stroke patients-differentiation between cerebral ischemic events and cerebral hemorrhage
A large number of stroke patients is treated by the Mainz-EMS during the first hours after the onset of symptoms. A combination of anamnestic and clinical variables included in the score prehospitally leads to the tentative diagnosis confirmed by CT-scan in the majority of cases. It should therefore be possible in the future to initiate specific therapy for stroke patients prehospitally.