Spleen Scanning as an Aid to Tumour Diagnostics

Fecal Blood Loss in Patients With Colonic Polyps: A Comparison of Measurements With 51Chromium-Labeled Erythrocytes and With the Haemoccult Test

Abstract The quantitative determinations of fecal daily blood loss after intravenous administration of 51Cr-labeled erythrocytes in 44 patients with colonic polyps and in 11 controls were compared with the results of the daily performed Haemoccult test without dietary restrictions. A total of 642 stool specimens was analyzed for 51Cr loss and the Haemoccult test. The mean fecal daily blood loss in the 34 patients with adenomatous polyps of the descending colon and rectosigmoid was 1.36 ± 0.14 ml/day (mean ± SEM), in the 10 patients with polyps of the ascending and transverse colon it was 1.28 ± 0.31 ml/day, and in the 11 controls 0.62 ± 0.07 ml/day. There was no positive Haemoccult test in …

Identification and quantitation of methotrexate and methotrexate metabolites in clinical high-dose therapy by high pressure liquid chromatography and field desorption mass spectrometry.

High-pressure liquid chromatography in combination with field desorption mass spectrometry as techniques of high specificity and sensitivity have been applied to the identification and quantitation of the anticancer drug methotrexate and its metabolites which occur in clinical high-dose therapy. Field desorption mass spectra of methotrexate and several methotrexate and folic acid derivatives, when investigated as free acids or ammonium salts, yield abundant protonated molecular ions and a consistent pattern of structurally significant fragments. High-pressure liquid chromatographic separation of methotrexate metabolites was performed on reverse-phase, C-18 columns using a volatile, ammonium…