0000000000133472

AUTHOR

V. Lietuvietis

showing 4 related works from this author

The Obesity Paradox Predicts the Second Wave of COVID-19 to Be Severe in Western Countries.

2021

While COVID-19 infection and mortality rates are soaring in Western countries, Southeast Asian countries have successfully avoided the second wave of the SARS-CoV-2 pandemic despite high population density. We provide a biochemical hypothesis for the connection between low COVID-19 incidence, mortality rates, and high visceral adiposity in Southeast Asian populations. The SARS-CoV-2 virus uses angiotensin-converting enzyme 2 (ACE2) as a gateway into the human body. Although the highest expression levels of ACE2 are found in people’s visceral adipose tissue in Southeast Asia, this does not necessarily make them vulnerable to COVID-19. Hypothetically, high levels of visceral adiposity cause s…

Intra-Abdominal FatHealth Toxicology and Mutagenesislcsh:MedicinePhysiologyAdipose tissueACE2030209 endocrinology & metabolismIntra-Abdominal FatPeptidyl-Dipeptidase ASoutheast asianSystemic inflammationWhite People03 medical and health sciences0302 clinical medicineAsian PeopleMedicineHumansObesityvisceral adipose tissuePandemicsAsia Southeastern030304 developmental biologyAdiposityInflammationsystemic inflammation0303 health sciencesbusiness.industrySARS-CoV-2Mortality rateIncidencelcsh:RCOVID-19 ; visceral adipose tissue ; systemic inflammation ; SARS-CoV-2 ; ACE2 ; weight gain ; second wave ; Quarantine-15Public Health Environmental and Occupational HealthCOVID-19weight gainmedicine.diseaseObesitysecond waveQuarantine-15PerspectiveAngiotensin-Converting Enzyme 2medicine.symptombusinessWeight gainObesity paradoxInternational journal of environmental research and public health
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Alkylresorcinol Metabolites in Urine and Plasma as Potential Biomarkers of Rye and Wheat Fiber Consumption in Prostate Cancer Patients and Controls

2015

Alkylresorcinols (ARs) are phytochemicals mainly associated with rye/wheat bran. Plasma ARs and their plasma and urine metabolites are considered as biomarkers for whole-grain rye/wheat intake. However ARs metabolite day and night variations have not been studied in prostate cancer patients yet. We investigated ARs metabolites 3, 5-dihydroxy-benzoic acid (DHBA), and 3-(3, 5-dihydroxyphenyl)-1-propanoic acid (DHPPA) in urine and plasma in prostate cancer patients and in control group. DHPPA in 12-h overnight urine correlated with the intake of rye bread and bread fiber across short time periods (3 days). Plasma DHPPA concentration was significantly greater in the prostate cancer group than i…

Dietary FiberMaleCancer Researchmedicine.medical_specialty030309 nutrition & dieteticsMetaboliteMedicine (miscellaneous)030209 endocrinology & metabolismUrineExcretion03 medical and health scienceschemistry.chemical_compoundProstate cancer0302 clinical medicineAlkylresorcinolInternal medicineHydroxybenzoatesmedicineHumansTriticumAged0303 health sciencesNutrition and DieteticsPhenylpropionatesBranSecaledigestive oral and skin physiologyCase-control studyProstatic Neoplasmsfood and beveragesBreadResorcinolsMiddle Agedmedicine.disease6. Clean waterCircadian Rhythm3. Good healthEndocrinologyOncologychemistryBiochemistryCase-Control StudiesPotential biomarkersBiomarkersNutrition and Cancer
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CD63 and Dna Mismatch Repair Protein Expression in Prostate Cancer

2021

Abstract Protein expression levels in immunohistochemistry and molecular biomarkers have been reported for their ability to predict recurrence, progression, development of metastases, and patient survival. The molecular features in low- and high-grade prostate cancer can differ and influence treatment decision and prognosis. The objective of the current study was to compare the expression of exosomal biomarkers CD63 and mismatch repair proteins (MSH2, MSH6, MLH1, and PMS2) by immunohistochemistry (IHC) in tissue of patients with prostate cancer and benign hyperplasia. Altogether, 62 patients with prostate acinar adenocarcinoma and 20 patients with prostate benign hyperplasia were enrolled i…

0301 basic medicineCD63business.industrymedicine.diseasedigestive system diseases03 medical and health sciencesProstate cancer030104 developmental biology0302 clinical medicine030220 oncology & carcinogenesisCancer researchMedicinebusinessDNA Mismatch Repair ProteinProceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
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Consumption of the Whole-Grain Rye Bread and Progression of Prostate Cancer

2013

Abstract Whole-grain rye intake has been suggested to have anti-cancer effect, including changes in serum hormones and reduced prostate specific antigen (PSA) in animals and humans. In this study, we investigated the effect of high intake of whole-grain rye bread on prostate cancer progression as assessed by PSA concentration in men diagnosed with prostate cancer. Fifteen men with prostate cancer who did not receive prior therapy were randomised and given a daily supplement of 250 g refined wheat bread for two weeks and, afterwards, 250 g whole-grain rye bread for six weeks. Blood samples were taken from fasting men at baseline and after two and six weeks to measure the PSA and sex hormones…

2. Zero hungerRye breadConsumption (economics)MultidisciplinaryGeneral interestScienceQdigestive oral and skin physiology030232 urology & nephrologyrye breadfood and beveragesprostate cancermedicine.diseasesex hormonesWhole grains3. Good healthpsa03 medical and health sciencesProstate cancer0302 clinical medicine030220 oncology & carcinogenesismedicineFood scienceProceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences
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