0000000000133783
AUTHOR
Michael Schmid
Second report on chicken genes and chromosomes 2005.
International audience
Die Vielgestaltigkeit der Virushepatitis
Bei der gemeinsamen Planung war von Anfang an klar, das nur einige Fragen und Themen aufgegriffen werden konnten, die uns auch fur den praktisch tatigen Internisten von besonderer Wichtigkeit erschienen. Aber es sollten auch Probleme aufgegriffen werden, die von grundsatzlicher Bedeutung zum Verstandnis neuerer Entwicklungen sind.
Chicken orthologues of mammalian imprinted genes are clustered on macrochromosomes and replicate asynchronously.
In the chicken genome, most orthologues of mouse imprinted genes are clustered on macrochromosomes. Only a few orthologues are located in the microchromosome complement. Macrochromosomal and, to a lesser extent, microchromosomal regions containing imprinted gene orthologues exhibit asynchronous DNA replication. We conclude that highly conserved arrays of imprinted gene orthologues were selected during vertebrate evolution, long before these genes were recruited for parent-specific gene expression by genomic imprinting mechanisms. Evidently, the macrochromosome complement provides a better chromatin environment for the establishment of asynchronous DNA replication and imprinted gene expressi…