0000000000134160

AUTHOR

Emmanouela Repapi

showing 3 related works from this author

Genome-wide association study identifies five loci associated with lung function

2009

Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (n < or = 32,184 additional individuals) and in silico summary association data from the CHARGE Consortium (n = 21,209) and the Health 2000 survey (n < or = 883). We confirmed the reported locus at 4q31 and identified associations with FEV(1) or FEV(1)/FVC and co…

OncologySpirometryMalemedicine.medical_specialtyVital capacityPopulationReceptor for Advanced Glycation End ProductsVital CapacityGenome-wide association studyBiologyPolymorphism Single NucleotideArticlePulmonary function testing03 medical and health sciencesFEV1/FVC ratioPulmonary Disease Chronic Obstructive0302 clinical medicineMeta-Analysis as TopicInternal medicineTensinsForced Expiratory VolumeGeneticsmedicineHumansRNA MessengerReceptors ImmunologiceducationLung030304 developmental biologyGlutathione Transferase0303 health scienceseducation.field_of_studyCOPDmedicine.diagnostic_testGenome HumanGene Expression ProfilingMicrofilament Proteinsrespiratory systemmedicine.disease3. Good healthRespiratory Function Tests030228 respiratory systemSpirometryImmunologyFemaleReceptors Serotonin 5-HT4Hedgehog interacting proteinThrombospondinsGenome-Wide Association Study
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A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample

2011

Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication have provided conflicting results. Recently, we undertook a meta-analysis of Genome Wide Association Study (GWAS) results for lung function measures in 20,288 individuals from the general population (the SpiroMeta consortium). OBJECTIVES: To comprehensively analyse previously reported genetic associations with lung function measures, and to investigate whether single nucleotide polymorphisms (SNPs) in these genomic regions…

PulmonologyChronic Obstructive Pulmonary DiseasesEpidemiologyVital Capacitylcsh:MedicineGenome-wide association studyBioinformaticsPDE4DPulmonary function testingPulmonary Disease Chronic Obstructive0302 clinical medicineForced Expiratory VolumePHOSPHODIESTERASE 4D GENElcsh:ScienceLungRISK0303 health scienceseducation.field_of_studyCOPDMultidisciplinaryAlpha 1-antitrypsin deficiencyGreat BritainALPHA(1)-ANTITRYPSIN DEFICIENCYta3141ta3142respiratory system3142 Public health care science environmental and occupational health3. Good healthRespiratory Function Testsmedicine.anatomical_structureGenetic EpidemiologyScience & Technology - Other TopicsMedicineBiological MarkersHEALTHResearch Articlemedicine.medical_specialtyGeneral Science & TechnologyPopulationObstructive pulmonary-disease; Phosphodiesterase 4D gene; Alpha(1)-antitrypsin deficiency; Health; PDE4D; RiskPolymorphism Single NucleotideOBSTRUCTIVE PULMONARY-DISEASE03 medical and health sciencesMeta-Analysis as TopicMolecular geneticsMD MultidisciplinarymedicineGeneticsGenome-Wide Association StudiesHumansGenetic Predisposition to DiseaseeducationBiology030304 developmental biologyAsthmaScience & TechnologyLungMULTIDISCIPLINARY SCIENCESbusiness.industryGenome Humanlcsh:RSmoking Related DisordersSpiroMeta Consortiummedicine.diseaseUnited KingdomAsthmarespiratory tract diseasesGenetics of Diseaselcsh:Qbusiness030217 neurology & neurosurgeryBiomarkersGenome-Wide Association Study
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Fundamental period of infilled reinforced concrete frame structures

2016

AbstractThe fundamental period of vibration appears to be one of the most critical parameters for the seismic design and assessment of structures. In the present paper, the results of a large-scale analytical investigation on the parameters that affect the fundamental period of reinforced concrete structures are presented. The influence of the number of storeys, the number of spans, the span length, the infill wall panel stiffness and the percentage of openings within the infill panel on the fundamental period of infilled RC frames was investigated. Based on these results, a regression analysis is applied in order to propose a new empirical equation for the estimation of the fundamental per…

EngineeringInfill wallModal analysis0211 other engineering and technologies020101 civil engineeringOcean Engineering02 engineering and technologyreinforced concrete frame buildingSpan (engineering)0201 civil engineeringSeismic analysisregression analysiFundamental periodmedicineInfillGeotechnical engineeringSafety Risk Reliability and QualityCivil and Structural Engineering021110 strategic defence & security studiesmodal analysibusiness.industryinfilled frameMechanical EngineeringStiffnessStructural engineeringBuilding and ConstructionMasonryGeotechnical Engineering and Engineering GeologyVibrationSettore ICAR/09 - Tecnica Delle Costruzionimasonrymedicine.symptombusiness
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