0000000000134854
AUTHOR
Eduardo Alegría
Multicenter and all-comers validation of a score to select patients for manual thrombectomy, the DDTA score.
Background Routine manual thrombectomy (MT) is not recommended in primary percutaneous coronary intervention (P-PCI) but it is performed in many procedures. The objective of our study was validating the DDTA score, designed for selecting patients who benefit most from MT. Methods Observational and multicenter study of all consecutive patients undergoing P-PCI in five institutions. Results were compared with the design cohort and the performance of the DDTA was analyzed in all patients. Primary end-point of the analyses was TIMI 3 after MT; secondary endpoints were final TIMI 3, no-reflow incidence, in-hospital mortality and in-hospital major cardiovascular events (MACE). In-hospital prognos…
Transplantation of Mesenchymal Stem Cells Exerts a Greater Long-Term Effect than Bone Marrow Mononuclear Cells in a Chronic Myocardial Infarction Model in Rat
The aim of this study is to assess the long-term effect of mesenchymal stem cells (MSC) transplantation in a rat model of chronic myocardial infarction (MI) in comparison with the effect of bone marrow mononuclear cells (BM-MNC) transplant. Five weeks after induction of MI, rats were allocated to receive intramyocardial injection of 106 GFP-expressing cells (BM-MNC or MSC) or medium as control. Heart function (echocardiography and 18F-FDG-microPET) and histological studies were performed 3 months after transplantation and cell fate was analyzed along the experiment (1 and 2 weeks and 1 and 3 months). The main findings of this study were that both BM-derived populations, BM-MNC and MSC, ind…
Documento Abordaje de la dislipidemia. Sociedad Española de Arteriosclerosis (parte III)
Unidad de Riesgo Cardiovascular y Lipidos, Departamento de Medicina Interna, Hospital General Universitario Gregorio aranon, Universidad Complutense, Madrid, Espana Servicio de Cardiologia, Clinica Universitaria de Pamplona, Universidad de Navarra, Pamplona, Espana Unidad de Lipidos, Servicio de Medicina Interna, Hospital Clinico, Universidad de Valencia, Valencia, Espana Unidad de Lipidos, Servicio de Medicina Interna, Hospital Carlos III, Madrid, Espana Miembro del grupo de Lipidos de SEMFYC, Centro de Salud Prosperidad, Madrid, Espana Unidad de Lipidos, Servicio de Medicina Interna, Hospital del Mar, Universidad Autonoma, Barcelona, Espana Unidad de Lipidos, Servicio de Medicina Interna,…