0000000000135078
AUTHOR
Ainars Bajinskis
Radiation-induced changes in levels of selected proteins in peripheral blood serum of breast cancer patients as a potential triage biodosimeter for large-scale radiological emergencies
The threat of a large scale radiological emergency, where thousands of people may require fast biological dosimetry for the purpose of triage, makes it necessary to search for new, high throughput biological dosimeters. The authors tested an assay based on the quantitative analysis of selected proteins in peripheral blood serum. They were particularly interested in testing proteins that are specific to irradiation of skin, as these can be used in cases of partial body exposure. Candidate proteins were identified in an earlier study with mice, where skin of the animals was exposed to different doses of radiation and global expression of serum proteins was analyzed. Eight proteins were found,…
[I062] The roles of radiographers in medical imaging and radiotherapy in Europe
Very fast development of technologies in medical imaging and therapy has changed the role of radiographer in Europe. Over the past ten years education and necessary skills and competencies for radiographers has become more similar in most EU countries due to input of EFRS Educational Wing, but there are still rather significant differences in the roles of radiographers between countries. Role expansion is often initiated by external and internal factors that lead to advanced practice for radiographers. However, there is also a limiting factor that functions as a barrier for development of radiographer’s role and mainly that is connected to resistance when radiologists/medical physicists obj…
Micronucleus frequencies and clonogenic cell survival in TK6 cells exposed to changing dose rates under controlled temperature conditions.
In most exposure scenarios the dose rate of exposure is not constant. Despite this, very little information exists on the possible biological effects of exposing cells to radiation under the conditions of a changing dose rate. The current study highlights interesting effects following exposure under these conditions.We constructed a new exposure facility that allows exposing cells inside an incubator and used it to irradiate human lymphoblastoid TK6 cells both after a moderate (0.48 Gy) and a high (1.1 Gy) dose, where the change in dose rate was, respectively, ≈ 17-fold (2.2-37 mGy/min) and ≈ 39-fold (2.7-106 mGy/min). Clonogenic survival and micronuclei (MN) induction were the chosen endpo…