0000000000135587

AUTHOR

Julia Teister

showing 5 related works from this author

Correlation of Crystallin Expression and RGC Susceptibility in Experimental Glaucoma Rats of Different Ages.

2018

Glaucoma is one of the leading causes of blindness worldwide with age being an important risk factor. However, the pathogenesis remains poorly understood. Aim of this study was to focus on age-dependent molecular changes in an experimental animal model of glaucoma.Intraocular pressure was elevated in Sprague-Dawley rats aged 3, 14, and 47 weeks for a period of 7 weeks by episcleral vein cauterization. Ganglion cell loss was monitored by an immunohistochemical staining of the Brain-specific homeobox/POU (Pit-1, Oct-2, Unc-86) domain protein 3A positive cells in retinal flat-mounts and spectral-domain optical coherence tomography measuring the retinal nerve fiber layer thickness. Molecular pr…

ProteomicsRetinal Ganglion CellsIntraocular pressureAgingGlaucomaCell CountBioinformaticsMass SpectrometryRetinaCorrelationPathogenesisRats Sprague-Dawley03 medical and health sciencesCellular and Molecular NeuroscienceTonometry Ocular0302 clinical medicineNerve FibersCrystallinMedicineAnimalsRisk factorIntraocular PressureBlindnessbusiness.industryGlaucomamedicine.diseaseCrystallinsSensory SystemsOphthalmologyDisease Models AnimalAgeing030221 ophthalmology & optometryFemalebusiness030217 neurology & neurosurgeryTomography Optical CoherenceCurrent eye research
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Modulation of the Immune System for the Treatment of Glaucoma

2017

Background At present intraocular pressure (IOP) lowering therapies are the only approach to treat glaucoma. Neuroprotective strategies to protect the retinal ganglion cells (RGC) from apoptosis are lacking to date. Substantial amount of research concerning the role of the immune system in glaucoma has been performed in the recent years. This review aims to analyse changes found in the peripheral immune system, as well as selected local changes of retina immune cells in the glaucomatous retina. Methods By dividing the immune system into the innate and the adaptive immune system, a systematic literature research was performed to find recent approaches concerning the modulation of the immune …

0301 basic medicinegenetic structuresT cellsGlaucomaAdaptive ImmunityRetinal ganglionArticleImmunomodulation03 medical and health sciences0302 clinical medicineImmune systemAntigenmedicineAnimalsHumansPharmacology (medical)PharmacologyB cellsToll-like receptorRetinabiologybusiness.industryGeneral Medicinemedicine.diseaseAcquired immune systemImmunity Innateeye diseasesimmune systemPsychiatry and Mental healthglaucoma030104 developmental biologymedicine.anatomical_structureNeurologyImmunologybiology.proteinneuroprotectionsense organsNeurology (clinical)Antibodybusiness030217 neurology & neurosurgeryCurrent Neuropharmacology
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The Small Heat Shock Protein α-Crystallin B Shows Neuroprotective Properties in a Glaucoma Animal Model

2017

Glaucoma is a neurodegenerative disease that leads to irreversible retinal ganglion cell (RGC) loss and is one of the main causes of blindness worldwide. The pathogenesis of glaucoma remains unclear, and novel approaches for neuroprotective treatments are urgently needed. Previous studies have revealed significant down-regulation of α-crystallin B as an initial reaction to elevated intraocular pressure (IOP), followed by a clear but delayed up-regulation, suggesting that this small heat-shock protein plays a pathophysiological role in the disease. This study analyzed the neuroprotective effect of α-crystallin B in an experimental animal model of glaucoma. Significant IOP elevation induced b…

0301 basic medicineProteomicsRetinal Ganglion Cellsgenetic structuresNerve fiber layerGlaucomaCell CountMass Spectrometrylcsh:ChemistryPathogenesischemistry.chemical_compound0302 clinical medicineexperimental glaucoma; α-crystallin B; neuroprotection; proteomicsProtein Interaction Mapslcsh:QH301-705.5Spectroscopyα-crystallin BGeneral MedicineComputer Science ApplicationsUp-Regulationmedicine.anatomical_structureNeuroprotective AgentsRetinal ganglion cellneuroprotectionRetinal Neuronsmedicine.medical_specialtyDown-RegulationBiologyNeuroprotectionCatalysisArticleInorganic Chemistry03 medical and health sciencesCrystallinOphthalmologyHeat shock proteinmedicineElectroretinographyAnimalsPhysical and Theoretical ChemistryMolecular BiologyIntraocular Pressureexperimental glaucomaOrganic Chemistryalpha-Crystallin B ChainRetinalGlaucomamedicine.diseaseeye diseasesDisease Models Animal030104 developmental biologylcsh:Biology (General)lcsh:QD1-999chemistry030221 ophthalmology & optometrysense organsInternational Journal of Molecular Sciences; Volume 18; Issue 11; Pages: 2418
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Dynamics, alterations, and consequences of minimally invasive intraocular pressure elevation in rats.

2014

PURPOSE: An important, yet not exclusive, aspect of primary open angle glaucoma is elevated intraocular pressure (IOP) profiles within fluctuations and pressure peaks. The study aimed at establishing minimally invasive methods for recurrent IOP elevation in rats to investigate the impact of IOP dynamics and pathomorphologic retinal alterations during and after IOP elevation. METHODS: Intraocular pressure was elevated unilaterally in Long Evans rats to a level of ≈35 mm Hg for 1 hour in a total of 30 manipulations within 6 weeks, by using two methods: (1) suction-cup oculopression and (2) loop-adjusted oculopression. Retinal thickness (RT) was measured via optical coherence tomography (OCT),…

Retinal degenerationMaleRetinal Ganglion Cellsmedicine.medical_specialtyIntraocular pressuregenetic structuresOpen angle glaucomachemistry.chemical_compoundTonometry OcularOptical coherence tomographyOphthalmologymedicineAnimalsRats Long-EvansRetinal thinningIntraocular Pressuremedicine.diagnostic_testbusiness.industryRetinal DegenerationRetinalmedicine.diseaseeye diseasesRatsDisease Models Animalmedicine.anatomical_structureRetinal ganglion cellchemistryAnesthesiaOptic nerveDisease Progressionsense organsbusinessGlaucoma Open-AngleTomography Optical CoherenceFollow-Up StudiesInvestigative ophthalmologyvisual science
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Peripapillary fluorescence lifetime reveals age-dependent changes using fluorescence lifetime imaging ophthalmoscopy in rats

2017

Abstract Many fundus diseases accompany fundus autofluorescence change. Fluorescence lifetime imaging ophthalmoscope (FLIO) is a latest technique in imaging fundus autofluorescence. With FLIO, the fundus fluorescence lifetime (FLT) is recorded topographically, assisting to diagnose and monitor multiple fundus diseases. The purpose of this study was to evaluate the repeatability of FLT using FLIO on adult rats and to analyze the age-dependency of the peripapillary FLT of the fundus in a short spectral channel (498–560 nm) and a long spectral channel (560–720 nm). Sprague Dawley rats (n of eyes = 10) were used for repeatability experiments. Age-dependent changes were investigated in young (tw…

0301 basic medicineAgingmedicine.medical_specialtyFluorescence-lifetime imaging microscopygenetic structuresFundus OculiOptic DiskAge dependentFundus (eye)FluorescenceRetinaRats Sprague-DawleyOphthalmoscopy03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineOphthalmologySprague dawley ratsAnimalsMedicineFluorescein Angiographymedicine.diagnostic_testbusiness.industryReproducibility of ResultsRepeatabilityFluorescenceeye diseasesSensory SystemsFundus autofluorescenceRatsOphthalmoscopyOphthalmology030104 developmental biologyModels Animal030221 ophthalmology & optometryFemalesense organsbusinessExperimental Eye Research
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