TEMPORAL STRUCTURE OF THE MUSCULAR DYSTROPHY X-LINKED MOUSE BEHAVIOUR TESTED IN OPEN FIELD

In comparison with wilde type mice, animal models of Duchenne Muscolar Dystrophy (mdx mice) show a different behavioral organization with a more articulated structure of the temporal patterns. Present study sheds light, for the first time, on specific temporal features of behavior in an animal model of DMD.

Temporal structure of the rat's behavior in elevated plus maze test

Aim of the research was to evaluate, by means of quantitative and multivariate temporal pattern analyses, the behavior of Wistar rat in elevated plus maze (EPM) test. On the basis of an ethogram encompassing 24 behavioral elements, quantitative results showed that 130.14 ± 8.01 behavioral elements occurred in central platform and in closed arms (protected zones), whereas 88.62 ± 6.04 occurred in open arms (unprotected zones). Percent distribution was characterized by a prevalence of sniffing, walking and vertical exploration. Analysis of minute-by-minute duration evidenced a decrease for time spent in open arms and central platform and an increase for time spent in closed arms. As to multiv…

Significant divergences between the temporal structure of the behavior in Wistar and in the spontaneously more anxious DA/Han strain of rats tested in elevated plus maze

Abstract The aim of present research is to study the temporal structure of the behavior in two strains of rats with different basal level of emotionality. To this purpose, the temporal profile of the behavior in Wistar rat and in the spontaneously more anxious DA/Han strain was analyzed in the Elevated Plus Maze. Both quantitative and multivariate t-pattern analyses were carried out. In comparison with Wistar, DA/Han subjects showed a significant reduction of the permanence in open arm and a significant increase of the time spent in the central platform of the maze. Mean frequencies of each behavioral element showed significant modifications both in open and in closed arm. Multivariate t-pa…

Role of nitric oxide on the conrol of the dopaminergic Nigrostriatal system: a combined electrophysiological And dialysis analysis in rats

Modifications of the spontaneous bioelectric activity and of the after discharge evoked in the amygdala after pallidal injection of kainic acid in the cat.

Publisher Summary This chapter explains the modifications of the spontaneous bioelectric activity and of the after discharge (AD) evoked in the amygdala after pallidal injection of kainic acid (KA) in the cat. An experiment was conducted in which injection of KA, a neurotoxic drug analog of glutamate, was made into the entopeduncolar nucleus (EN), the equivalent of the medial globus pallidus of primates, to observe the modifications produced on the spontaneous amygdaloid bioelectric activity and on the evoked AD. An AD was evoked in the amygdala by stimulation of the ipsilateral pyriform cortex. The duration of the amygdaloid AD was related to the stimulus parameters. In the same animal, th…

Multivariate temporal pattern analysis applied to the study of rat behavior in the elevated plus maze: Methodological and conceptual highlights

Aim of this article is to illustrate the application of a multivariate approach known as t-pattern analysis in the study of rat behavior in elevated plus maze. By means of this multivariate approach, significant relationships among behavioral events in the course of time can be described. Both quantitative and t-pattern analyses were utilized to analyze data obtained from fifteen male Wistar rats following a trial 1 - trial 2 protocol. In trial 2, in comparison with the initial exposure, mean occurrences of behavioral elements performed in protected zones of the maze showed a significant increase counterbalanced by a significant decrease of mean occurrences of behavioral elements in unprote…

INFLAMMATION IN PARKINSON'S DISEASE

Crucial Role of the 5-HT2C Receptor in Regulating the Activity of the Substantia Nigra Pars Reticulata Neurons: An Electrophysiological Study in Rats. 5th Forum of European Neuroscience - Vienna

CRUCIAL ROLE OF THE 5-HT2C RECEPTOR IN REGULATING THE ACTIVITY OF THE SUBSTANTIA NIGRA PARS RETICULATA NEURONS: AN ELECTROPHYSIOLOGICAL STUDY IN RATS

T-Patterns in the study of movement disorders

An intrinsic feature of behaviour orbits around its temporal dimension consisting of patterns in time: investigations on behaviour necessarily deal with sequences often impossible to be perceived by the human eye [Eibl-Eibesfeldt I. Ethology: the biology of behavior. New York: Holt, Rinehart and Winston. 1970]. Thus, the study of behavioural sequencing in terms of higher order arrangements, how the sequences are structured and, importantly, their analysis in normal subjects and in subjects affected by specific movement/behavioural disorders may represent a stimulating but challenging task. By means of T-Pattern analysis (TPA), it is possible to study these hidden features of behaviour and, …

Endurance training increases infiammatori cells in small airways of mice.