6533b826fe1ef96bd12845a9

RESEARCH PRODUCT

Modifications of the spontaneous bioelectric activity and of the after discharge evoked in the amygdala after pallidal injection of kainic acid in the cat.

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Publisher Summary This chapter explains the modifications of the spontaneous bioelectric activity and of the after discharge (AD) evoked in the amygdala after pallidal injection of kainic acid (KA) in the cat. An experiment was conducted in which injection of KA, a neurotoxic drug analog of glutamate, was made into the entopeduncolar nucleus (EN), the equivalent of the medial globus pallidus of primates, to observe the modifications produced on the spontaneous amygdaloid bioelectric activity and on the evoked AD. An AD was evoked in the amygdala by stimulation of the ipsilateral pyriform cortex. The duration of the amygdaloid AD was related to the stimulus parameters. In the same animal, the AD duration did not greatly change when stimulation parameters remained constant. Stereotaxically microinjection of KA was effected in the EN ipsilateral to the amygdaloid deriving electrodes. Few minutes after the injection of the drug, a decrease of the AD duration was observed likely linked to the excitatory effect of KA on the EN neurons that increased its inhibitory effect on the amygdaloid complex. The results of the experiment contribute to underline excitatory effect and subsequently damaging of KA on EN neurons allowing one to confirm a control role of the globus pallidus on the spontaneous and evoked paroxystic amygdaloid activity.