0000000000140281
AUTHOR
Andreas Maier
Motion Artifact Detection in Confocal Laser Endomicroscopy Images
Confocal Laser Endomicroscopy (CLE), an optical imaging technique allowing non-invasive examination of the mucosa on a (sub)- cellular level, has proven to be a valuable diagnostic tool in gastroenterology and shows promising results in various anatomical regions including the oral cavity. Recently, the feasibility of automatic carcinoma detection for CLE images of sufficient quality was shown. However, in real world data sets a high amount of CLE images is corrupted by artifacts. Amongst the most prevalent artifact types are motion-induced image deteriorations. In the scope of this work, algorithmic approaches for the automatic detection of motion artifact-tainted image regions were develo…
Patch-based Carcinoma Detection on Confocal Laser Endomicroscopy Images -- A Cross-Site Robustness Assessment
Deep learning technologies such as convolutional neural networks (CNN) provide powerful methods for image recognition and have recently been employed in the field of automated carcinoma detection in confocal laser endomicroscopy (CLE) images. CLE is a (sub-)surface microscopic imaging technique that reaches magnifications of up to 1000x and is thus suitable for in vivo structural tissue analysis. In this work, we aim to evaluate the prospects of a priorly developed deep learning-based algorithm targeted at the identification of oral squamous cell carcinoma with regard to its generalization to further anatomic locations of squamous cell carcinomas in the area of head and neck. We applied the…
Transferability of Deep Learning Algorithms for Malignancy Detection in Confocal Laser Endomicroscopy Images from Different Anatomical Locations of the Upper Gastrointestinal Tract
Squamous Cell Carcinoma (SCC) is the most common cancer type of the epithelium and is often detected at a late stage. Besides invasive diagnosis of SCC by means of biopsy and histo-pathologic assessment, Confocal Laser Endomicroscopy (CLE) has emerged as noninvasive method that was successfully used to diagnose SCC in vivo. For interpretation of CLE images, however, extensive training is required, which limits its applicability and use in clinical practice of the method. To aid diagnosis of SCC in a broader scope, automatic detection methods have been proposed. This work compares two methods with regard to their applicability in a transfer learning sense, i.e. training on one tissue type (f…
Direct Measurement of Focusing Fields in Active Plasma Lenses
Physical review accelerators and beams 21(12), 122801 (2018). doi:10.1103/PhysRevAccelBeams.21.122801
Effects of functional endoscopic sinus surgery on the acoustics of the sinonasal tract
Background: Nasal and paranasal cavities are supposed to contribute substantially to the vocal tract resonator properties. However, their acoustical effects as well as the effects of sinus surgery on the voice remain unclear. In this work we investigate resonance phenomena of paranasal sinuses prior to and after various rhinosurgical procedures in cadaveric human sinonasal tracts and corresponding 3D casts. Methodology: Nasal and paranasal cavities of formalin-preserved cadavers and corresponding 3D replicas were excited by sine tone sweeps from an earphone placed in the epipharynx.The response was picked up by a microphone at the nostrils. Different FESS procedures were performed and the a…
ICDAR 2021 Competition on Historical Document Classification
International audience; This competition investigated the performance of historical document classification. The analysis of historical documents is a difficult challenge commonly solved by trained humanists. We provided three different classification tasks, which can be solved individually or jointly: font group/script type, location, date. The document images are provided by several institutions and are taken from handwritten and printed books as well as from charters. In contrast to previous competitions, all participants relied upon Deep Learning based approaches. Nevertheless, we saw a great performance variety of the different submitted systems. The easiest task seemed to be font grou…
From point to area: Upscaling approaches for Late Quaternary archaeological and environmental data
Abstract The study of past socio-environmental systems integrates a variety of terrestrial archives. To understand regional or continental socio-environmental interactions proxy data from local archives need to be transferred to larger spatial scales. System properties like spatial heterogeneity, historical and spatial contingency, nonlinearity, scale dependency or emergence make generalizations from local observations to larger scales difficult. As these are common properties of natural and social systems, the development of an interdisciplinary upscaling framework for socio-environmental systems remains a challenge. For example, the integration of social and environmental data is often hi…
Cultural evolution and environmental change in Central Europe between 40 and 15 ka
The role of environmental change in the evolution of cultural traits is a topic of long-standing scientific debate with strongly contrasting views. Major obstacles for assessing environmental impacts on the evolution of material culture are the fragmentary nature of archaeological and – to a somewhat lesser extent – geoscientific archives and the insufficient chronological resolution of these archives and related proxy data. Together these aspects are causing difficulties in data synchronization. By no means does this paper attempt to solve these issues, but rather aims at shifting the focus from demonstrating strict chains of causes and events to describing roughly contemporaneous developm…
Direct Measurement of Focusing Fields in Active Plasma Lenses
Active plasma lenses have the potential to enable broad-ranging applications of plasma-based accelerators owing to their compact design and radially symmetric kT/m-level focusing fields, facilitating beam-quality preservation and compact beam transport. We report on the direct measurement of magnetic field gradients in active plasma lenses and demonstrate their impact on the emittance of a charged particle beam. This is made possible by the use of a well-characterized electron beam with 1.4 mm mrad normalized emittance from a conventional accelerator. Field gradients of up to 823 T/m are investigated. The observed emittance evolution is supported by numerical simulations, which suggest the …